Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats

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dc.contributor.authorTüreyen, Kudret
dc.contributor.buuauthorŞahin, Soner
dc.contributor.buuauthorAlkan, Tülin
dc.contributor.buuauthorTemel, Şehime Gülsün
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.buuauthorKorfali, Ender
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-2892-2021tr_TR
dc.contributor.researcheridAAH-1792-2021tr_TR
dc.contributor.researcheridAAG-8385-2021tr_TR
dc.contributor.scopusid8272141000tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.contributor.scopusid6507885442tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid7004641343tr_TR
dc.date.accessioned2021-12-02T08:47:35Z
dc.date.available2021-12-02T08:47:35Z
dc.date.issued2010-02
dc.description.abstractThe effects of citicoline used either alone or in combination with hypothermia on the suppression of apoptotic processes after transient focal cerebral ischemia were investigated. Middle cerebral artery occlusion (MCAo) was performed for 2 hours on Sprague-Dawley (SD) rats using intraluminal thread insertion. The treatment groups were as follows: Group 1, sham-operate 1; Group 2, saline; Group 3, citicoline (400 mg/kg intraperitoneal.); Group 4, hypothermia (34 +/- 1 degrees C); Group 5, citicoline + hypothermia. All rats were reperfused for 24 hours, and after sacrifice and transcardiac perfusion, immunohistochemical (mean standard deviation, 0.71 +/- 0.75) was lower compared to Groups 3, 4 and 5 (2.33 +/- 0.81; 3.00 +/- 0.00; 2.20 +/- 0.83; p < 0.05). There was higher expression of cispase-3 proteins in Group 2 (2.28 +/- 0.95) compared to Group 5 (1.50 +/- 0.83; p < 0.05). Bax proteins were also increased in Group 2 (1.85 +/- 1.06) compared to Group 5 (0.40 +/- 0.54) and in Group 4 (2.00 +/- 0.00) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Significant differences in caspase-9 immunostaining scores were found in Group 2 (2.29 +/- 0.96) compared to Group 5 (0.20 +/- 0.44) (p < 0.05); Group 3 (1.00 +/- 0.70) compared to Group 5 (0.20 +/- 0.44: p, < 0.05); and Group 4 (3.00 +/- 0.00; p < 0.05) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Thus by suppressing apoptotic processes citicoline with hypothermia is more effective than ;either used alone in ameliorating cerebral damage after transient focal ischemia.en_US
dc.identifier.citationŞahin, S. vd. (2010). "Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats". Journal of Clinical Neuroscience, 17(2), 227-231.en_US
dc.identifier.endpage231tr_TR
dc.identifier.issn0967-5868
dc.identifier.issue2tr_TR
dc.identifier.pubmed20036128tr_TR
dc.identifier.scopus2-s2.0-73449126488tr_TR
dc.identifier.startpage227tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2009.05.016
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0967586809003701
dc.identifier.urihttp://hdl.handle.net/11452/22949
dc.identifier.volume17tr_TR
dc.identifier.wos000274445900018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCerebral ischemiaen_US
dc.subjectCiticolineen_US
dc.subjectHypothermiaen_US
dc.subjectRaten_US
dc.subjectModerate therapeutic hypothermiaen_US
dc.subjectTransient forebrain ischemiaen_US
dc.subjectCDP-cholineen_US
dc.subjectArtery occlusionen_US
dc.subjectCaspase activationen_US
dc.subjectCell-deathen_US
dc.subjectBrainen_US
dc.subjectReperfusionen_US
dc.subjectMetabolismen_US
dc.subjectPathwayen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.emtreeCaspase 3en_US
dc.subject.emtreeCaspase 9en_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeProtein baxen_US
dc.subject.emtreeProtein bcl 2en_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrain damageden_US
dc.subject.emtreeBrain protectionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease markeren_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeHeart perfusionen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeInduced hypothermiaen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle cerebral artery occlusionen_US
dc.subject.emtreeNeuroprotectionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSham procedureen_US
dc.subject.emtreeSuturing methoden_US
dc.subject.emtreeTransient ischemic attacken_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshApoptosis regulatory proteinsen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBrainen_US
dc.subject.meshBrain infarctionen_US
dc.subject.meshBrain ischemiaen_US
dc.subject.meshCombined modality therapyen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshHypothermia, induceden_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInfarctionen_US
dc.subject.meshMiddle cerebral arteryen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve degenerationen_US
dc.subject.meshNeuronsen_US
dc.subject.meshNeuroprotective agentsen_US
dc.subject.meshNootropic agentsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReperfusion injuryen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleEffects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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