Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis

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dc.contributor.authorYılmaz, Yusuf
dc.contributor.authorEren, Fatih
dc.contributor.authorÇolak, Yaşar
dc.contributor.authorKurt, Ramazan
dc.contributor.authorŞenateş, Ebubekir
dc.contributor.authorTuncer, İlyas
dc.contributor.authorİmeryuz, Neşe
dc.contributor.buuauthorAyyıldız, Talat
dc.contributor.buuauthorDolar, Enver
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.contributor.scopusid6603155277tr_TR
dc.contributor.scopusid6602075084tr_TR
dc.date.accessioned2021-12-29T10:49:43Z
dc.date.available2021-12-29T10:49:43Z
dc.date.issued2011-11-20
dc.description.abstractBackground: Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to the metabolic syndrome in the general population. However, the relationship between serum PEDF and nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, remains unknown. Methods: We assayed serum PEDF levels in 156 patients with biopsy-proven NAFLD and 103 nonsteatotic control subjects who were matched for age and sex. The association between levels of PEDF and clinical, biochemical, and histological phenotypes was examined. Results: NAFLD patients had significantly higher serum PEDF levels (1.97 +/- 0.50 mu g/mL) than control subjects (1.51 +/- 0.49 mu g/mL, Student's t test, P<0.001). Multivariable-adjusted stepwise regression analysis showed that PEDF ([beta] = 0.32, t = 3.13, P = 0.002) and triglycerides ([beta] = 0.22, t = 2.23. P = 0.02) were, in the order they entered into the model, the main independent predictors of steatosis scores in our patients with NAFLD. Conclusions: Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD and are associated with liver steatosis independently of traditional risk factors.en_US
dc.description.sponsorshipMarmara Üniversitesitr_TR
dc.identifier.citationYılmaz, Y. vd. (2011). ''Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis''. Clinica Chimica Acta, 412(23-24), 2296-2299.en_US
dc.identifier.endpage2299tr_TR
dc.identifier.issn0009-8981
dc.identifier.issue23-24tr_TR
dc.identifier.pubmed21888902tr_TR
dc.identifier.scopus2-s2.0-80053635378tr_TR
dc.identifier.startpage2296tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.cca.2011.08.025
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21888902/
dc.identifier.urihttp://hdl.handle.net/11452/23731
dc.identifier.volume412tr_TR
dc.identifier.wos000296686100047tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectPigment epithelium-derived factoren_US
dc.subjectNonalcoholic fatty liver diseaseen_US
dc.subjectEnzyme-linked immunosorbent assayen_US
dc.subjectSteatosisen_US
dc.subjectEndothelial growth-factoren_US
dc.subjectFactor pedfen_US
dc.subjectMetabolic syndromeen_US
dc.subjectInsulin-resistanceen_US
dc.subjectAngiogenesisen_US
dc.subjectActivationen_US
dc.subjectCellsen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeCholesterolen_US
dc.subject.emtreeLow density lipoprotein cholesterolen_US
dc.subject.emtreePigment epithelium derived factoren_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeClinical assessmenten_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiastolic blood pressureen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeFatty liveren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHomeostasisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHhuman tissueen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetabolic syndrome Xen_US
dc.subject.emtreeNonalcoholic fatty liveren_US
dc.subject.emtreePhenotypeen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeSystolic blood pressureen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsyen_US
dc.subject.meshEye proteinsen_US
dc.subject.meshFatty liveren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMultivariate analysisen_US
dc.subject.meshNerve growth factorsen_US
dc.subject.meshReproducibility of resultsen_US
dc.subject.meshSerpinsen_US
dc.subject.scopusPigment Epithelium-Derived Factor; Type 6 Osteogenesis Imperfecta; Angiogenesis Inhibitorsen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleSerum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosisen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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