Prevention of nickel-induced allergic contact reactions with pentoxifylline

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dc.contributor.authorWhite, Ian Richard
dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.buuauthorBülbül, Emel
dc.contributor.buuauthorPalalı, Zeki
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.contributor.scopusid6507149072tr_TR
dc.contributor.scopusid6602430771tr_TR
dc.date.accessioned2021-09-13T08:24:13Z
dc.date.available2021-09-13T08:24:13Z
dc.date.issued1998
dc.description.abstractIn this study, we investigated the effect of pentoxifylline, an inhibitor of TNF-alpha, on the contact sensitivity response induced by nickel. For induction, open epicutaneous sensitization by NiSO4 . 6 H2O (25% aq.) solution was applied on the backs of 38 albino guinea pigs 5 days a week for 4 weeks. NaCl (0.9%) solution was applied epicutaneously to 10 albino-guinea pigs as a control group. 19 were sensitized by nickel and developed positive patch test reactions. Patch tests were repeated after 10 of the sensitized pigs were given pentoxifylline 20 mg/kg/day orally. At the end of this study, only 2 positive patch test reactions were observed in the pentoxifylline-treated group, while 7/9 of the untreated guinea pigs developed positive reactions. These results suggest that pentoxifylline inhibits the contact sensitivity response induced by nickel only during drug administration.en_US
dc.identifier.citationSarıcaoğlu, H. vd. (1998). "Prevention of nickel-induced allergic contact reactions with pentoxifylline". Contact Dermatitis, 39(5), 244-247.en_US
dc.identifier.endpage247tr_TR
dc.identifier.issn0105-1873
dc.identifier.issue5tr_TR
dc.identifier.pubmed9840261tr_TR
dc.identifier.scopus2-s2.0-0031757162tr_TR
dc.identifier.startpage244tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1600-0536.1998.tb05917.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1998.tb05917.x
dc.identifier.urihttp://hdl.handle.net/11452/21880
dc.identifier.volume39tr_TR
dc.identifier.wos000077270700006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalContact Dermatitisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergyen_US
dc.subjectDermatologyen_US
dc.subjectPentoxifyllineen_US
dc.subjectExperimental nickel sensitizationen_US
dc.subjectGuinea pigsen_US
dc.subjectInhibition elicitation phaseen_US
dc.subjectGuinea-pigen_US
dc.subjectHypersensitivity reactionsen_US
dc.subjectElicitation phaseen_US
dc.subjectDermatitisen_US
dc.subjectSensitizationen_US
dc.subjectVasculitisen_US
dc.subjectIrritanten_US
dc.subjectDiseaseen_US
dc.subject.emtreeAntithrombocytic agenten_US
dc.subject.emtreeNickelen_US
dc.subject.emtreeNickel sulfateen_US
dc.subject.emtreePentoxifyllineen_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeContact dermatitisen_US
dc.subject.emtreeContact sensitivityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeGuinea pigen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOral drug administrationen_US
dc.subject.emtreePatch testen_US
dc.subject.scopusLocal Lymph Node Assay; Skin Allergy; Sensitizationen_US
dc.subject.wosAllergyen_US
dc.subject.wosDermatologyen_US
dc.titlePrevention of nickel-induced allergic contact reactions with pentoxifyllineen_US
dc.typeArticle
dc.wos.quartileQ3 (Allergy)en_US

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