Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients

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dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.buuauthorDilek, Kamil
dc.contributor.buuauthorYurtkuran, Mustafa Abbas
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.scopusid55665181500tr_TR
dc.contributor.scopusid56005080200tr_TR
dc.contributor.scopusid7003389525tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2021-09-06T06:31:20Z
dc.date.available2021-09-06T06:31:20Z
dc.date.issued2002-05
dc.description.abstractObjectives: This study was undertaken to determine the changes in plasma free choline and choline-containing compounds in end stage renal disease (ESRD) and to determine if they were lost into the dialysate during hemodialysis. Design and methods: Plasma and dialysate free choline, phosphocholine and phospholipid, phosphatidylcholine-, sphingomyelin-bound choline were measured before, during and after hemodialysis. Results: Plasma free and bound choline concentrations (mean +/- standard error of the mean) were 12.9 +/- 0.6 and 2697 +/- 57 muM or 37.3 +/- 0.9 and 2792 +/- 98 muM in controls or in ESRD patients, respectively. Free choline concentrations were correlated (r = 0.598 p < 0.001) with the time the patients were subjected to hemodialysis. Plasma free choline and phosphocholine concentrations a-re decreased by a total of -8.1 +/- 0.6 μmol/L and -88 +/- 8 μmol/L, respectively: phospholipid- phosphatidylcholine- and sphingomyelin-bound choline are increased, during hemodialysis. Patients lost about 350 μmoles of choline into the dialysate during hemodialysis. Conclusion: Plasma free choline concentrations are elevated in ESRD. and a considerable amount of choline is lost into the hemodialysate.en_US
dc.identifier.citationÖzarda, Y. vd. (2002). "Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients". Clinical Biochemistry , 35(3), 233-239.en_US
dc.identifier.endpage239tr_TR
dc.identifier.issn0009-9120
dc.identifier.issue3tr_TR
dc.identifier.pubmed12074832tr_TR
dc.identifier.scopus2-s2.0-0036017355tr_TR
dc.identifier.startpage233tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0009-9120(02)00298-9
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912002002989
dc.identifier.urihttp://hdl.handle.net/11452/21689
dc.identifier.volume35tr_TR
dc.identifier.wos000176492200011tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.journalClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholineen_US
dc.subjectSphingomyelinen_US
dc.subjectPhosphocholineen_US
dc.subjectPhosphatidylcholineen_US
dc.subjectEnd stage renal diseaseen_US
dc.subjectHemodialysisen_US
dc.subjectRat Corpus Striatumen_US
dc.subjectAcetylcholine-releaseen_US
dc.subjectParenteral-nutritionen_US
dc.subjectTyrosine-hydroxylaseen_US
dc.subjectBrain phospholipidsen_US
dc.subjectDeficiencyen_US
dc.subjectCytidineen_US
dc.subjectNeuronsen_US
dc.subjectLiveren_US
dc.subject.scopusCholine; Dimethylglycine; Betainesen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleChanges of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patientsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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