Changes in circulating adiponectin and tumour necrosis factor-alpha and their relationship with insulin resistance in periparturient dairy cows

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dc.contributor.buuauthorMecitoğlu, Zafer
dc.contributor.buuauthorŞentürk, Sezgin
dc.contributor.buuauthorAkgül, Gülsah
dc.contributor.buuauthorUdum, Duygu
dc.contributor.buuauthorUzabacı, Ender
dc.contributor.buuauthorKasap, Sevim
dc.contributor.buuauthorÇatık, Serkan
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7052-1694tr_TR
dc.contributor.orcid0000-0002-2465-9913tr_TR
dc.contributor.orcid0000-0002-5557-121Xtr_TR
dc.contributor.orcid0000-0002-9634-0055tr_TR
dc.contributor.researcheridAAH-5167-2021tr_TR
dc.contributor.researcheridAAH-5069-2021tr_TR
dc.contributor.researcheridAAH-1677-2021tr_TR
dc.contributor.researcheridAAP-7998-2020tr_TR
dc.contributor.scopusid36457647300tr_TR
dc.contributor.scopusid56257771200tr_TR
dc.contributor.scopusid56604015400tr_TR
dc.contributor.scopusid31967936400tr_TR
dc.contributor.scopusid55347697800tr_TR
dc.contributor.scopusid36514844800tr_TR
dc.contributor.scopusid56515323800tr_TR
dc.date.accessioned2023-04-13T12:00:16Z
dc.date.available2023-04-13T12:00:16Z
dc.date.issued2016-05-13
dc.description.abstractIntroduction: The aim of the study was to investigate changes in the serum levels of adiponectin and TNF-alpha, as well as insulin sensitivity, and to elucidate the possible relationship among the parameters and negative energy balance during the periparturient period of dairy cows. Material and Methods: Thirty primiparous Holstein dairy cows were selected for the study. Blood samples were collected from each cow seven days before the expected calving date, on the calving day, and 7, 14, and 21 days after calving. Blood non-esterified fatty acids (NEFA), beta-hydroxybutyric acid (BHBA), glucose, insulin, adiponectin, and TNF- alpha levels were measured. Revised Quantitative Insulin Sensitivity Check Index (rQUICKI) was calculated using data on NEFA, insulin, and glucose concentrations. Results: When compared to prepartum levels, serum concentration of adiponectin significantly increased on day 21 postpartum. The rQUICKI increased and NEFA levels decreased on day 7 after parturition. Insulin and glucose levels decreased on days 7, 14, and 21 postpartum when compared with prepartum levels. BHBA levels decreased on day 21 and TNF- alpha concentration also decreased on days 7, 14, and 21 postpartum. Adiponectin levels positively correlated with NEFA during the preparturient period. Negative correlation was detected between adiponectin and rQUICKI on calving day and on 14th day after parturition. TNF- alpha concentration positively correlated with glucose levels on day 7 prepartum and on 21st day postpartum and with rQUICKI on 21st day postpartum. Negative correlation was detected between adiponectin level and insulin sensitivity. Conclusion: Based on the results of the study, we concluded that adiponectin could possibly increase insulin sensitivity when blood NEFA concentrations are elevated.en_US
dc.identifier.citationMecitoğlu, Z. vd. (2016). "Changes in circulating adiponectin and tumour necrosis factor-alpha and their relationship with insulin resistance in periparturient dairy cows". Journal of Veterinary Research, 60(2), 163-167.en_US
dc.identifier.endpage167tr_TR
dc.identifier.issn2450-7393
dc.identifier.issn2450-8608
dc.identifier.issue2tr_TR
dc.identifier.scopus2-s2.0-85010049706tr_TR
dc.identifier.startpage163tr_TR
dc.identifier.urihttps://doi.org/10.1515/jvetres-2016-0024
dc.identifier.urihttps://sciendo.com/article/10.1515/jvetres-2016-0024
dc.identifier.urihttp://hdl.handle.net/11452/32375
dc.identifier.volume60tr_TR
dc.identifier.wos000378095300008tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.bapKUAP(V)-2012/46tr_TR
dc.relation.journalJournal of Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectCowsen_US
dc.subjectPerinatal perioden_US
dc.subjectAdiponectinen_US
dc.subjectTNF-alphaen_US
dc.subjectInsulin resistanceen_US
dc.subjectFatty-acid oxidationen_US
dc.subjectGrowth-hormoneen_US
dc.subjectGlucoseen_US
dc.subjectLactationen_US
dc.subjectSensitivityen_US
dc.subjectExpressionen_US
dc.subjectObesityen_US
dc.subjectMarkeren_US
dc.subjectMuscleen_US
dc.subjectTissueen_US
dc.subject.scopusAdiponectin Receptors; Adiponectin; Hypoadiponectinemiaen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleChanges in circulating adiponectin and tumour necrosis factor-alpha and their relationship with insulin resistance in periparturient dairy cowsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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