Kanser tedavisinde hipertermi: Biyolojik temel
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Date
1993-04-19
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Uludağ Üniversitesi
Abstract
Hipertermi (HT) özellikle son 20 yılda önem kazanan bir tedavi yöntemidir. Hiperterminin oluşturduğu hücre ölümü radyasyona bağlı olandan oldukça farklıdır. Gl fazı HT'ye en dirençli faz iken S-fazı en duyarlı olan farzdır. Bunun dışında HT aynı zamanda tümör hücrelerini düşük LET ionizan radyasyona duyarlı kılar. Isı sitotoksisitesi iyonizan radyasyonun kinden oldukça farklı olarak termotoleransdan, düşük pH dan ve nutrisyonel yetersizlikten etkilenirken akut hipoksiden bağımsızdır. Isı sitoteks sitesinde kan dolaşımı da önemli rol oynar. Termotolerans siyah ya da diğer bazı sitotoksik ajanlara maruziyet ile oluşan HT'ye karşı direnç gelişi midir. Tümör pH sının akut olarak düşürülmesi HT'ye duyarlılığı artırır. Çoğu tümörde pH'nın düşük olması ve hipoksi nedeniyle radyorezistan olmaları HT ile radyoterapiyi kombine etmek için en güçlü temeli oluşturur. HT ayrıca birçok sitotoksik ajan etkinliğini de arttırır.
Hyperthermia (HT) has gained a great interest in the past two decades. The nature of hyperthermia induced cell lethality is quite different from that of radiation-induced killing. The G1-phase cells are quite sensitive. In addition to heat-induced cytotoxicity, HT sensitizes cells to low LET ionizing radiation. Unlike the response to ionizing radiation, heat cytotoxicity is influenced by thermotolerance, low pH and nutritional deprivation, but is independent of acute hypoxia. Also, blood flow influences the heating characteristics of a tumor relative to normal tissue. Thermotolerance is a non-heritable resistance to HT induced by exposure to heat and other cytotoxic agents. Cells are sensitized to HT damage by acutely lowering pH, and thermotolerance development is reduced at low pH. Reduced pH also enhances thermal radiosensitization. Since much of a tumor population is at low pH, and these tum or eels are very likely to be hypoxic and radioresistant, this offer is one of the strongest reasons for combining HIIT with radiation therapy. HT sensitizes the eel to many cytotoxic agents and even converts the same drugs that are innocuous to highly toxic.
Hyperthermia (HT) has gained a great interest in the past two decades. The nature of hyperthermia induced cell lethality is quite different from that of radiation-induced killing. The G1-phase cells are quite sensitive. In addition to heat-induced cytotoxicity, HT sensitizes cells to low LET ionizing radiation. Unlike the response to ionizing radiation, heat cytotoxicity is influenced by thermotolerance, low pH and nutritional deprivation, but is independent of acute hypoxia. Also, blood flow influences the heating characteristics of a tumor relative to normal tissue. Thermotolerance is a non-heritable resistance to HT induced by exposure to heat and other cytotoxic agents. Cells are sensitized to HT damage by acutely lowering pH, and thermotolerance development is reduced at low pH. Reduced pH also enhances thermal radiosensitization. Since much of a tumor population is at low pH, and these tum or eels are very likely to be hypoxic and radioresistant, this offer is one of the strongest reasons for combining HIIT with radiation therapy. HT sensitizes the eel to many cytotoxic agents and even converts the same drugs that are innocuous to highly toxic.
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Keywords
Hipertermi, Radyoterapi, Sitotoksisite, Radyosensitizasyon, Onkoloji, Hyperthermia, Radiotherapy, Cytotoxicity, Radiosensitization, Oncology
Citation
Engin, K. (1994). ''Kanser tedavisinde hipertermi: Biyolojik temel''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 21(1), 87-90.