Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervals

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dc.contributor.authorSucu, Derya Kaynak
dc.contributor.authorAslan, Diler
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorHızlı, Banu Zafer
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid14019332100tr_TR
dc.date.accessioned2021-12-07T06:01:50Z
dc.date.available2021-12-07T06:01:50Z
dc.date.issued2009-12
dc.description.abstractMethylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect. folate and total homocysteine (tHcy) status This study was designed to determine the rate of,MTHFR 677C->T and 1298A->C mutations. and their Influence Oil serum folate, Hcy and vitamin B12 Status and the reference intervals in 402 healthy Turkish adults. The rate of MTHFR 677C->T or 1298A->C mutations was 50 7% or 54 7%. respectively. The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype. all subjects had lower serum folate and 54% of the subjects had higher tHcy concentration,; than the cutoff Values of <= 10 nmol/L and >= 12 mu mol/L, respectively. Serum vitamin 1312 status was similar in all genotypes Serum tHcy concentrations were inversely correlated with serum folate and vitamin B12 concentrations in all genotypes These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.en_US
dc.identifier.citationİlçöl, Y. Ö. vd. (2009). "Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervals". Cell Biochemistry and Function, 27(8), 568-577.en_US
dc.identifier.endpage577tr_TR
dc.identifier.issn0263-6484
dc.identifier.issue8tr_TR
dc.identifier.pubmed19764044tr_TR
dc.identifier.scopus2-s2.0-71949087027tr_TR
dc.identifier.startpage568tr_TR
dc.identifier.urihttps://doi.org/10.1002/cbf.1610
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbf.1610
dc.identifier.urihttp://hdl.handle.net/11452/23020
dc.identifier.volume27tr_TR
dc.identifier.wos000272576800010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.bap2002/34tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFolateen_US
dc.subjectHomocysteineen_US
dc.subjectMTHFRen_US
dc.subjectMutationsen_US
dc.subjectReference intervalsen_US
dc.subjectTurkeyen_US
dc.subjectVitamin B12en_US
dc.subjectMethylenetetrahydrofolate reductase geneen_US
dc.subjectApproved recommendation 1987en_US
dc.subjectCollected reference valuesen_US
dc.subjectCoronary-artery-diseaseen_US
dc.subject3rd national-healthen_US
dc.subjectPlasma homocysteineen_US
dc.subjectCardiovascular-diseaseen_US
dc.subjectCommon mutationen_US
dc.subjectRisk-factoren_US
dc.subjectStatistical treatmenten_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subject.emtree5,10 methylenetetrahydrofolate reductase (FADH2)en_US
dc.subject.emtreeAlanineen_US
dc.subject.emtreeCyanocobalaminen_US
dc.subject.emtreeCysteineen_US
dc.subject.emtreeFolic aciden_US
dc.subject.emtreeHomocysteineen_US
dc.subject.emtreeMethionineen_US
dc.subject.emtreeThreonineen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAlleleen_US
dc.subject.emtreeAmino acid blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFolic acid blood levelen_US
dc.subject.emtreeGene locusen_US
dc.subject.emtreeGene mutationen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHomozygoteen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman experimenten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMethylationen_US
dc.subject.emtreeMutation rateen_US
dc.subject.emtreeNormal humanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeVitamin metabolismen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFolic aciden_US
dc.subject.meshGenotypeen_US
dc.subject.meshHealth statusen_US
dc.subject.meshHomocysteineen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylenetetrahydrofolate reductase (NADPH2)en_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPoint mutationen_US
dc.subject.meshTurkeyen_US
dc.subject.meshVitamin B 12en_US
dc.subject.meshYoung adulten_US
dc.subject.scopusClinical Chemistry; Thyrotropin; Nonparametric Methodsen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.titleRate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervalsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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