Characterization of nonalcoholic fatty liver disease unrelated to the metabolic syndrome

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dc.contributor.authorYılmaz, Yusuf
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorÇolak, Yaşar
dc.contributor.authorTuncer, İlyas
dc.contributor.authorÖvünç, Ayşe Oya Kurdaş
dc.contributor.authorKalaycı, Cem
dc.contributor.buuauthorAyyıldız, Talat
dc.contributor.buuauthorDolar, Enver
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.contributor.scopusid6603155277tr_TR
dc.contributor.scopusid6602075084tr_TR
dc.date.accessioned2021-12-02T08:39:33Z
dc.date.available2021-12-02T08:39:33Z
dc.date.issued2012-04
dc.description.abstractBackground Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome (MS). However, not all patients with the MS will develop NAFLD and not all patients with NAFLD have the MS. We sought to investigate the differences between patients with biopsy-proven NAFLD with and without the MS. Methods A total of 357 consecutive patients with biopsy-proven NAFLD were analysed. Of them, 216 patients had nonalcoholic steatohepatitis (NASH) and 96 a fibrosis score = 2. The MS was defined as = 3 of the ATP III criteria. Results A total of 214 patients with NAFLD met the criteria for the MS, while the remaining 143 did not. In NAFLD patients with the MS, homeostasis model of insulin resistance (P = 0.03; OR, 1.06; 95% CI, 1.0231.25 per unit increase) and diabetes (P = 0.01; OR, 1.2; 95% CI, 1.12.4) were independent predictors of NASH. In NAFLD patients without the MS, the only variable independently associated with NASH was haemoglobin (P = 0.007; OR, 1.9; 95% CI, 1.43.6 per 50 g/L increase). Alanine aminotransferase (P = 0.03; OR, 1.04; 95% CI, 1.0061.11 per 10 U/L increase) was an independent predictor of fibrosis = 2 in NAFLD patients with the MS, while haemoglobin (P = 0.02; OR, 1.4; 95% CI, 1.21.9 per 50 g/L increase) was the only variable significantly associated with fibrosis = 2 in NAFLD patients without the MS. Conclusions Increased haemoglobin in NAFLD subjects without MS should be considered in the selection of cases for histological assessment.en_US
dc.description.sponsorshipMarmara Universityen_US
dc.identifier.citationYılmaz, Y. vd. (2012). "Characterization of nonalcoholic fatty liver disease unrelated to the metabolic syndrome". European Journal of Clinical Investigation, 42(4), 411-418.en_US
dc.identifier.endpage418tr_TR
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.issue4tr_TR
dc.identifier.pubmed21913918tr_TR
dc.identifier.scopus2-s2.0-84858284683tr_TR
dc.identifier.startpage411tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1365-2362.2011.02597.x
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21913918/
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2362.2011.02597.x
dc.identifier.urihttp://hdl.handle.net/11452/22948
dc.identifier.volume42tr_TR
dc.identifier.wos000301491800010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Clinical Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectFibrosisen_US
dc.subjectHaemoglobinen_US
dc.subjectInsulin resistanceen_US
dc.subjectNonalcoholic steatohepatitisen_US
dc.subjectSteatohepatitisen_US
dc.subjectHemoglobinen_US
dc.subjectDiagnosisen_US
dc.subjectPathogenesisen_US
dc.subjectAssociationen_US
dc.subjectPopulationen_US
dc.subjectPrevalenceen_US
dc.subjectGuidelinesen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeHemoglobinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical assessment toolen_US
dc.subject.emtreeCross-sectional studyen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHemoglobin blood levelen_US
dc.subject.emtreeHomoestasis model of insulin resistanceen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeLiver fibrosisen_US
dc.subject.emtreeLiver histologyen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetabolic syndrome Xen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreeNonalcoholic fatty liveren_US
dc.subject.emtreePredictor variableen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeScoring systemen_US
dc.subject.meshAdulten_US
dc.subject.meshAge factorsen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshFatty liveren_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobinsen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMetabolic syndrome xen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshRoc curveen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSex factorsen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusFatty Liver; Proton Density (Concentration); Keratin-18en_US
dc.subject.wosMedicine, general & internalen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleCharacterization of nonalcoholic fatty liver disease unrelated to the metabolic syndromeen_US
dc.typeArticle
dc.wos.quartileQ1 (Medicine, general & internal)en_US
dc.wos.quartileQ2 (Medicine, research & experimental)en_US

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