Intrathecal epinephrine in combined spinal-epidural analgesia for labor: dose-response relationship for epinephrine added to a local anesthetic-opioid combination

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dc.contributor.buuauthorGurbet, Alp
dc.contributor.buuauthorTürker, Gürkan
dc.contributor.buuauthorKöse, Dilek
dc.contributor.buuauthorUçkunkaya, Nesimi
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6503-8232tr_TR
dc.contributor.orcid0000-0002-3019-581Xtr_TR
dc.contributor.researcheridA-7994-2018tr_TR
dc.contributor.researcheridAAI-6642-2021tr_TR
dc.date.accessioned2021-08-23T10:24:46Z
dc.date.available2021-08-23T10:24:46Z
dc.date.issued2005-04
dc.description.abstractBackground: The purpose was to investigate the dose-response relationship for intrathecally administered epinephrine added to a local anesthetic-opioid combination in combined spinal-epidural analgesia for labor, in order to evaluate analgesia and side-effects. Patients and methods: The subjects were 100 consecutive ASA I or II parturients at > 37weeks' gestation, who received combined spinal-epidural analgesia during labor. Each woman was randomly assigned to one of five groups that received 2-mL volumes of different spinal solutions. The control group received an intrathecal injection of bupivacaine 2.5 mg and fentanyl 25 mu g only. The others received epinephrine 12.5, 25, 50 or 100 mu g added to this intrathecal regimen. Maternal arterial pressure, heart rate and pain scores were recorded before and 5, 10, 15 and 30 min after intrathecal injection. Level of sensory blockade, motor blockade score, duration of intrathecal analgesia, side effects, fetal heart rate, and 1- and 5-min Apgar scores were also assessed. Results: Compared to the control group, all four epinephrine groups had significantly longer duration of intrathecal analgesia, but the durations were similar. The frequencies of side effects were similar in all five groups. Conclusion: The results suggest that adding epinephrine to a combination of standard intrathecal doses of bupivacaine and fentanyl in combined spinal-epidural analgesia for labor significantly prolongs spinal analgesia. Of the four epinephrine doses tested, the lowest one (12.5 mu g) was optimal for this clinical setting.en_US
dc.identifier.citationGurbet, A. vd. (2005). "Intrathecal epinephrine in combined spinal-epidural analgesia for labor: dose-response relationship for epinephrine added to a local anesthetic-opioid combination". International Journal of Obstetric Anesthesia, 14(2), 121-125.en_US
dc.identifier.endpage125tr_TR
dc.identifier.issn0959-289X
dc.identifier.issue2tr_TR
dc.identifier.pubmed15795147tr_TR
dc.identifier.scopus2-s2.0-15944396415tr_TR
dc.identifier.startpage121tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ijoa.2004.12.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0959289X04001827
dc.identifier.urihttp://hdl.handle.net/11452/21523
dc.identifier.volume14tr_TR
dc.identifier.wos000228612900007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scien_US
dc.relation.journalInternational Journal of Obstetric Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLabor analgesiaen_US
dc.subjectEpinephrineen_US
dc.subjectCombined spinal-epiduralen_US
dc.subjectBlood-flowen_US
dc.subjectCorden_US
dc.subjectSufentanilen_US
dc.subjectBupivacaineen_US
dc.subjectClonidineen_US
dc.subjectFentanylen_US
dc.subjectAnesthesiologyen_US
dc.subjectObstetrics & gynecologyen_US
dc.subject.scopusEpidural Analgesia; Labor Pain; Ropivacaineen_US
dc.subject.wosAnesthesiologyen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleIntrathecal epinephrine in combined spinal-epidural analgesia for labor: dose-response relationship for epinephrine added to a local anesthetic-opioid combinationen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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