Rotavirus epidemiology of children in Bursa, Turkey: A multi-centered hospital-based descriptive study

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dc.contributor.buuauthorHacımustafaoğlu, Mustafa Kemal
dc.contributor.buuauthorÇelebi, Solmaz
dc.contributor.buuauthorAğın, Mehmet
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0297-846Xtr_TR
dc.contributor.researcheridA-4421-2016tr_TR
dc.contributor.scopusid6602154166tr_TR
dc.contributor.scopusid7006095295tr_TR
dc.contributor.scopusid55121429700tr_TR
dc.contributor.scopusid16316866500tr_TR
dc.date.accessioned2022-01-03T10:52:45Z
dc.date.available2022-01-03T10:52:45Z
dc.date.issued2011
dc.description.abstractIn this multi-centered study, we aimed to evaluate the distributional incidence of rotavirus acute gastroenteritis (RVAGE) according to age groups and epidemiological features of hospitalized and outpatient cases in the city center of Bursa, Turkey. This study was carried out in a multi-centered setting that included the four largest hospitals dealing with more than 90% of the pediatric population in Bursa. Children under 15 years old with acute gastroenteritis (AGE) were included in the study. During a period of one year, all of the hospitalized AGE cases and initially one out of 15 systematically determined outpatient cases with AGE were included in the study. RV diagnosis was made by using monoclonal RV antigen kits (BioMerieux, France) in fresh stool. Of 542,199 annual general hospital visits in those four hospitals, 5,988 were diagnosed with AGE (1.1%). The annual general AGE incidence in children under 15 years of age was found to be 1.7% per year. The annual incidence of RVAGE was 2.8%, 2.5%, 1.5%, and 0.14% in the cases aged <1 year, <2 years, <5 years, and 5-14 years, respectively. The hospitalization rate of RVAGE was estimated to be 22.5%, 27%, 20%, and 12.5% in the cases aged <1 year, <2 years, <5 years, and 5-14 years, respectively. RVAGE comprised 21% of the outpatient AGE cases and 0.35% of the total general pediatric outpatient cases. Acute gastroenteritis (AGE)-related hospitalizations comprised 5.7% and RVAGE-related hospitalizations 1.6% of all hospitalizations. RVAGE comprised 28.5% of all AGE hospitalizations. It was found that the annual RVAGE-related hospitalization incidence was 629/100,000 in those aged <1 year, 553/100,000 in those aged <2 years, 293/100,000 in those aged <5 years, and 17/100,000 in those aged 5-14 years. Rotavirus acute gastroenteritis (RVAGE) in both hospitalized and outpatient cases was found to be higher (60%) in boys than girls. It was found that the RV positivity in hospitalized AGE cases was higher than in outpatient AGE cases (28.5% vs. 21%, p=0.002). Eighty-six percent of hospitalized and 76% of outpatient RVAGE cases were <5 years (p=0.018). When the monthly distribution of RVAGE was examined in hospitalized and outpatient cases, it was found that RVAGE increased rapidly after October and decreased after March in cases aged <5 years. The highest RV positivity rate was detected as 49.5% in January in hospitalized AGE cases and 31.5% in February for outpatient cases. In those <5 years, the lowest RV positivity rate was detected in the June-September period both in hospitalized (between 11-25%) and in outpatient (between 0-18%) cases. Nearly half (47%) of the hospitalized RVAGE in those <5 years were hospitalized in the January-March period. More than half of the outpatient RVAGE cases (55%) aged <5 years were detected in the January-March period. No meaningful differences were found in the monthly distribution and in the monthly RV positivity rates between hospitalized and outpatient cases. In conclusion, RV was found to be a significant etiologic agent in hospitalized (28.5%) and outpatient (21%) AGE cases in Bursa. Nearly 80% of the RVAGE cases were aged <5 years. Approximately half of the cases were seen in the January-March period. In January, half of the hospitalized cases and one-third of the outpatient AGE cases were RVAGE. Our findings have revealed a comparable pattern in RVAGE epidemiology in Bursa to that of the European countries and the United States.en_US
dc.identifier.citationHacımustafaoğlu, M. vd. (2011). "Rotavirus epidemiology of children in Bursa, Turkey: A multi-centered hospital-based descriptive study".Turkish Journal of Pediatrics, 53(6), 604-613.tr_TR
dc.identifier.endpage613tr_TR
dc.identifier.issn0041-4301
dc.identifier.issue6tr_TR
dc.identifier.pubmed22389982tr_TR
dc.identifier.scopus2-s2.0-84858730513tr_TR
dc.identifier.startpage604tr_TR
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22389982/
dc.identifier.urihttp://hdl.handle.net/11452/23813
dc.identifier.volume53tr_TR
dc.identifier.wos000301691100002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Pediatri Dergisitr_TR
dc.relation.journalTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPediatricsen_US
dc.subjectRotavirusen_US
dc.subjectEpidemiologyen_US
dc.subjectAcute gastroenteritisen_US
dc.subjectEnzyme immunoassaysen_US
dc.subjectCumulative risken_US
dc.subjectAcute Diarrheaen_US
dc.subjectAgeen_US
dc.subjectGastroenteritisen_US
dc.subjectEtiologyen_US
dc.subjectDiseaseen_US
dc.subjectAnkaraen_US
dc.subjectImpacten_US
dc.subject.emtreeVirus antigenen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeDescriptive researchen_US
dc.subject.emtreeFeces analysisen_US
dc.subject.emtreeFeces cultureen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneral hospitalen_US
dc.subject.emtreeHospital patienten_US
dc.subject.emtreeHospitalizationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOutpatienten_US
dc.subject.emtreePathogenesisen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreeRotavirusen_US
dc.subject.emtreeRotavirus infectionen_US
dc.subject.emtreeSchool childen_US
dc.subject.emtreeSeasonal variationen_US
dc.subject.emtreeSex differenceen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeViral gastroenteritisen_US
dc.subject.emtreeAcute diseaseen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeGastroenteritisen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreeRotavirus infectionen_US
dc.subject.emtreeSeasonen_US
dc.subject.emtreeStatisticsen_US
dc.subject.emtreeVirologyen_US
dc.subject.meshAcute diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroenteritisen_US
dc.subject.meshHospitalizationen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshRotavirus infectionsen_US
dc.subject.meshSeasonsen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusRotavirus Vaccines; Gastroenteritis; Intussusceptionen_US
dc.subject.wosPediatricsen_US
dc.titleRotavirus epidemiology of children in Bursa, Turkey: A multi-centered hospital-based descriptive studyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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