Impact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in rats

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dc.contributor.authorKayır, Hakan
dc.contributor.authorYavuz, Oğuzhan
dc.contributor.authorUzbay, Tayfun I.
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2021-12-31T10:43:07Z
dc.date.available2021-12-31T10:43:07Z
dc.date.issued2011-01-01
dc.description.abstractThe rats having high locomotor reactivity to a novel environment (LRNE) are known to be more vulnerable to develop locomotor sensitization, which reflects the initial neuroplastic changes in brain systems related to addictive behaviours. The present study aimed to investigate whether sensorimotor gating level, measured by prepulse inhibition (PPI) of acoustic startle reflex, also reflects vulnerability for nicotine sensitization. A batch of rats was assigned into three groups according to their baseline PPI values. The highest 1/3 and the lowest 1/3 proportions were selected and defined as high-inhibitory (HI) and low-inhibitory (LI) groups. LRNE was measured in the rats, then they were treated with nicotine (1 mg/kg, tartrate salt, subcutaneously) or saline and locomotor activity (LMA) was immediately recorded for 15 min. This procedure was performed daily for 5 successive days. After a 3-day drug-free period, all rats were challenged with nicotine (1 mg/kg) on 9th day and with saline on 12th day. Same sensitization protocol was applied in another batch of rats, except assigning them into the high-responder (HR) and low-responder(LR) groups according to LRNE levels. There was no significant difference between HI and LI rats in LRNE. Although the acute effect of nicotine on LMA was higher in HI rats, a locomotor sensitization developed and expressed only in LI rats. In the following experiments, nicotine stimulated LMA both in HR and LR rats, but induced and expressed locomotor sensitization only in HR rats. The present study shows that acute locomotor stimulant effect and locomotor sensitization developing effects of nicotine are associated with the baseline PPI and LRNE levels. But these two factors are independent from each other.en_US
dc.identifier.citationKayır, H. vd. (2011). "Impact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in rats". Behavioural Brain Research, 216(1), 275-280.en_US
dc.identifier.endpage280tr_TR
dc.identifier.issn0166-4328
dc.identifier.issue1tr_TR
dc.identifier.pubmed20708641tr_TR
dc.identifier.scopus2-s2.0-78149410521tr_TR
dc.identifier.startpage275tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2010.08.004
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20708641/
dc.identifier.urihttp://hdl.handle.net/11452/23789
dc.identifier.volume216tr_TR
dc.identifier.wos000285318500037tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosSSCIen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationSanayitr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBehavioural Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak1055387tr_TR
dc.relation.tubitakSBAG-3194tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehavioral sciencesen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPrepulse inhibitionen_US
dc.subjectNicotineen_US
dc.subjectLocomotor sensitizationen_US
dc.subjectIndividual vulnerabilityen_US
dc.subjectLocomotor reactivity to a novel environmenten_US
dc.subjectRat(s)en_US
dc.subjectSensorimotor gating deficitsen_US
dc.subjectIndividual-differencesen_US
dc.subjectBehavioral sensitizationen_US
dc.subjectIncentive-sensitizationen_US
dc.subjectSensation seekingen_US
dc.subjectNucleus-accumbensen_US
dc.subjectHigh impulsivityen_US
dc.subjectHealthy humansen_US
dc.subjectAnimal-modelsen_US
dc.subjectNitric-oxideen_US
dc.subject.emtreeNicotine tartrateen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeLocomotionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePrepulse inhibitionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSensory gatingen_US
dc.subject.emtreeStartle reflexen_US
dc.subject.emtreeStimulus responseen_US
dc.subject.emtreeTobacco dependenceen_US
dc.subject.meshAcoustic stimulationen_US
dc.subject.meshAnalysis of varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral nervous system stimulantsen_US
dc.subject.meshInhibition (psychology)en_US
dc.subject.meshMotor activityen_US
dc.subject.meshNicotineen_US
dc.subject.meshRatsen_US
dc.subject.meshSensory gatingen_US
dc.subject.meshStartle reactionen_US
dc.subject.scopusPrepulse Inhibition; Startle Reflex; Sensory Gatingen_US
dc.subject.wosBehavioral sciencesen_US
dc.subject.wosNeurosciencesen_US
dc.titleImpact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in ratsen_US
dc.typeArticle
dc.wos.quartileQ1 (Behavioral sciences)en_US
dc.wos.quartileQ2 (Neurosciences)en_US

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