Maspin expression in gastrointestinal stromal tumors

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dc.contributor.buuauthorAdım, Şaduman Balaban
dc.contributor.buuauthorFiliz, Gülaydan
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorÖzgüç, Halil Bülent
dc.contributor.buuauthorAytaç, Berna
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-9746-2021tr_TR
dc.contributor.scopusid15730076300tr_TR
dc.contributor.scopusid6602693514tr_TR
dc.contributor.scopusid55881548500tr_TR
dc.contributor.scopusid6603810549tr_TR
dc.contributor.scopusid6603867989tr_TR
dc.contributor.scopusid56527372000tr_TR
dc.date.accessioned2022-06-28T11:31:41Z
dc.date.available2022-06-28T11:31:41Z
dc.date.issued2010-03-26
dc.description.abstractBackground: To investigate the role of maspin expression in the progression of gastrointestinal stromal tumors, and its value as a prognostic indicator. Methods: In the study 54 patients with GIST diagnosis were included in Uludag University of Faculty of Medicine, Department of Pathology between 1997-2007. The expression of maspin in 54 cases of gastrointestinal stromal tumor was detected by immunohistochemistry and compared with the clinicopathologic tumor parameters. Results: The positive expression rates for maspin in the GISTs were 66,6% (36 of 54 cases). Maspin overexpression was detected in 9 of 29 high risk tumors (31%) and was significantly higher in very low/low (78.6%) and intermediate-risk tumors (63.6%) than high-risk tumors. Conclusions: Maspin expression might be an important factor in tumor progression and patient prognosis in GIST. In the future, larger series may be studied to examine the prognostic significance of maspin in GISTs and, of course, maspin expression may be studied in different mesenchymal tumors.en_US
dc.identifier.citationAdım, Ş. B. vd. (2010). "Maspin expression in gastrointestinal stromal tumors". World Journal of Surgical Oncology, 8.en_US
dc.identifier.issn1477-7819
dc.identifier.pubmed20346150tr_TR
dc.identifier.scopus2-s2.0-77952309178tr_TR
dc.identifier.urihttps://doi.org/10.1186/1477-7819-8-22
dc.identifier.urihttps://wjso.biomedcentral.com/articles/10.1186/1477-7819-8-22
dc.identifier.urihttp://hdl.handle.net/11452/27440
dc.identifier.volume8tr_TR
dc.identifier.wos000276760000001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.journalWorld Journal of Surgical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParadoxical expressionen_US
dc.subjectP53 expressionen_US
dc.subjectGeneen_US
dc.subjectCarcinomaen_US
dc.subjectCanceren_US
dc.subjectAngiogenesisen_US
dc.subjectProgressionen_US
dc.subjectMammaryen_US
dc.subjectSerpinen_US
dc.subjectCellsen_US
dc.subjectOncologyen_US
dc.subjectSurgeryen_US
dc.subject.emtreeMaspinen_US
dc.subject.emtreeSerine proteinase inhibitoren_US
dc.subject.emtreeSERPIN B5en_US
dc.subject.emtreeSERPIN-B5en_US
dc.subject.emtreeTumor markeren_US
dc.subject.emtreeAcute pancreatitisen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer diagnosisen_US
dc.subject.emtreeCancer growthen_US
dc.subject.emtreeCancer localizationen_US
dc.subject.emtreeCancer risken_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeGastrointestinal stromal tumoren_US
dc.subject.emtreeHigh risk patienten_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetastasisen_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeTumor growthen_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeEnzyme immunoassayen_US
dc.subject.emtreeGastrointestinal stromal tumoren_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeRisk factoren_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshDisease progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal stromal tumorsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme techniquesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeoplasm stagingen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSerpinsen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshTumor markers, biologicalen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusSERPIN-b5; Serine Proteinase Inhibitors; Serpinsen_US
dc.subject.wosOncologyen_US
dc.subject.wosSurgeryen_US
dc.titleMaspin expression in gastrointestinal stromal tumorsen_US
dc.typeArticle
dc.wos.quartileQ4 (Oncology)en_US
dc.wos.quartileQ3 (Surgery)en_US

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