Hepatic effects of halothane, isoflurane or sevoflurane anaesthesia in dogs

Simple item page
dc.contributor.buuauthorTopal, Ayşe
dc.contributor.buuauthorGül, Nihal Yaşar
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorGörgül, Osman Sacit
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid56357211200tr_TR
dc.contributor.scopusid55899103700tr_TR
dc.contributor.scopusid57210033454tr_TR
dc.contributor.scopusid6507730974tr_TR
dc.date.accessioned2021-10-07T13:10:15Z
dc.date.available2021-10-07T13:10:15Z
dc.date.issued2003-12
dc.description.abstractThe effects of halothane, isoflurane and sevoflurane anaesthesia on hepatic function and hepatocellular damage were investigated in dogs, comparing the activity of hepatic enzymes and bilirubin concentration in serum. An experimental study was designed. Twenty-one clinically normal mongrel dogs were divided into three groups and accordingly anaesthetized with halothane (n=7), isoflurane (n=7) and sevoflurane (n=7). The dogs were 1-4 years old, and weighed between 13.5 and 27 kg (18.4+/-3.9). Xylazine HCI (1-2 mg/kg) i.m. was used as pre-anaesthetic medication. Anaesthesia was induced with propofol 2 mg/kg i.v. The trachea was intubated and anaesthesia maintained with halothane, isoflurane or sevoflurane in oxygen at concentrations of 1.35, 2 and 3%, respectively. Intermittent positive pressure ventilation (tidal volume, 15 ml/kg; respiration rate, 12-14/min) was started immediately after intubation and the anaesthesia lasted for 60 min. Venous blood samples were collected before pre-medication, 24 and 48 h, and 7 and 14 days after anaesthesia. Serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH GGT) activities and bilirubin concentration were measured. Serum AST, ALT and GGT activities increased after anaesthesia, in all groups. In the halothane group, serum AST and ALT activities significantly increased all the time after anaesthesia compared with baseline activities. But in the isoflurane group AST and ALT activities increased only between 2 and 7 days, and in the sevoflurane group 7 days after anaesthesia. GGT activity was increased in the halothane group between 2 and 7 days, and in the isoflurane and sevoflurane groups 7 days after anaesthesia. All dogs recovered from anaesthesia without complications and none developed clinical signs of hepatic damage within 14 days. The results suggest that the use of halothane anaesthesia induces an elevation of serum activities of liver enzymes more frequently than isoflurane or sevoflurane from 2 to 14 days after anaesthesia in dogs. The effects of isoflurane or sevoflurane anaesthesia on the liver in dogs is safer than halothane anaesthesia in dogs.en_US
dc.identifier.citationTopal, A. vd. (2003). “Hepatic effects of halothane, isoflurane or sevoflurane anaesthesia in dogs”. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine, 50(10), 530-533.en_US
dc.identifier.endpage533tr_TR
dc.identifier.issn0931-184X
dc.identifier.issue10tr_TR
dc.identifier.pubmed15157022tr_TR
dc.identifier.scopus2-s2.0-3042850645tr_TR
dc.identifier.startpage530tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1439-0442.2004.00589.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1439-0442.2004.00589.x
dc.identifier.urihttp://hdl.handle.net/11452/22287
dc.identifier.volume50tr_TR
dc.identifier.wos000220782900010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishingen_US
dc.relation.journalJournal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectCanis familiarisen_US
dc.subjectLiveren_US
dc.subjectNecrosisen_US
dc.subject.emtreeAlkaline phosphataseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeEther derivativeen_US
dc.subject.emtreeGamma glutamyltransferaseen_US
dc.subject.emtreeHalothaneen_US
dc.subject.emtreeInhalation anesthetic agenten_US
dc.subject.emtreeIsofluraneen_US
dc.subject.emtreeLactate dehydrogenaseen_US
dc.subject.emtreeSevofluraneen_US
dc.subject.emtreeAnesthesiaen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAnimal diseaseen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzymologyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeLiveren_US
dc.subject.emtreeLiver function testen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePhysiologyen_US
dc.subject.meshAlkaline phosphataseen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnesthetics, inhalationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspartate aminotransferasesen_US
dc.subject.meshBilirubinen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGamma-glutamyltransferaseen_US
dc.subject.meshHalothaneen_US
dc.subject.meshIsofluraneen_US
dc.subject.meshL-lactate dehydrogenaseen_US
dc.subject.meshLiveren_US
dc.subject.meshLiver function testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMethyl ethersen_US
dc.subject.scopusSevoflurane; Halothane Hepatitis; Inhalation Anesthetic Agenten_US
dc.subject.wosVeterinary sciencesen_US
dc.titleHepatic effects of halothane, isoflurane or sevoflurane anaesthesia in dogsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus