Effects of perioperatively administered bupivacaine and bupivacaine-methylprednisolone on pain after lumbar discectomy

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dc.contributor.authorErsaylı, Deniz Tuna
dc.contributor.buuauthorGurbet, Alp
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorUçkunkaya, Nesimi
dc.contributor.buuauthorBilgin, Hulya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-6639-5533tr_TR
dc.contributor.orcid0000-0002-6503-8232tr_TR
dc.contributor.researcheridA-7338-2016tr_TR
dc.contributor.researcheridA-7994-2018tr_TR
dc.date.accessioned2021-09-07T13:32:36Z
dc.date.available2021-09-07T13:32:36Z
dc.date.issued2006-09-01
dc.description.abstractStudy Design. A prospective, randomized, controlled trial that compared the efficacy of different protocols of local tissue infiltration with bupivacaine or bupivacaine-methylprednisolone at the surgical site for pain relief after lumbar discectomy. Objective. To determine the efficacy of preemptive wound infiltration with bupivacaine and bupivacaine-methylprednisolone after lumbar discectomy. Summary of Background Data. Patients usually have significant pain after lumbar discectomy. Wound infiltration with bupivacaine or bupivacaine-methylprednisolone is one method to address this. Methods. Seventy-five patients were randomly allocated to 5 equal groups as follows: Group I (n = 15) had the musculus multifidi near the operated level infiltrated with 30 mL 0.25% bupivacaine and 40 mg methylprednisolone just before wound closure; Group II (n = 15) had the same region infiltrated with 30 mL 0.25% bupivacaine alone before closure; Group III (n = 15) had this region infiltrated with 30 mL 0.25% bupivacaine and 40 mg methylprednisolone before the incision was made; in Group IV (n = 15), this region infiltrated with 30 mL 0.25% bupivacaine alone before incision; and Group C (controls, n = 15) had this region infiltrated with 30 mL 0.9% NaCl just before wound closure. Demographics, vital signs, postoperative pain scores, and morphine usage were recorded. Results. All 4 groups treated with bupivacaine or bupivacaine-methylprednisolone ( by preemptive or preclosure wound infiltration) showed significantly better results than the control group for most parameters. The treated groups had lower parenteral opioid requirements after surgery, lower incidences of nausea, and shorter hospital stays. Further, the data indicate that, compared with infiltration of these drugs at wound closure, preemptive injection of bupivacaine or bupivacaine-methylprednisolone into muscle near the operative site provides more effective analgesia after lumbar discectomy. Conclusion. In addition, our data suggest that preemptive infiltration of the wound site with bupivacaine alone provides similar pain control to preemptive infiltration of the wound site with bupivacaine and methylprednisolone combined.en_US
dc.identifier.citationErsaylı, D. T. vd. (2006). ''Effects of perioperatively administered bupivacaine and bupivacaine-methylprednisolone on pain after lumbar discectomy''. Spine, 48(9), 595-605.en_US
dc.identifier.endpage605tr_TR
dc.identifier.issn0362-2436
dc.identifier.issue9tr_TR
dc.identifier.pubmed16946657tr_TR
dc.identifier.scopus2-s2.0-33748360937tr_TR
dc.identifier.startpage595tr_TR
dc.identifier.urihttps://doi.org/10.1097/01.brs.0000232801.19965.a0
dc.identifier.urihttps://journals.lww.com/spinejournal/Fulltext/2006/09010/Effects_of_Perioperatively_Administered.10.aspx
dc.identifier.urihttp://hdl.handle.net/11452/21748
dc.identifier.volume48tr_TR
dc.identifier.wos000240302200009tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalSpineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrthopedicsen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectWound infiltrationen_US
dc.subjectProspective randomized trialen_US
dc.subjectPreemptive analgesiaen_US
dc.subjectMethylprednisoloneen_US
dc.subjectLumbar discectomyen_US
dc.subjectBupivacaineen_US
dc.subjectTherapyen_US
dc.subjectAnalgesiaen_US
dc.subjectPulmonary complicationsen_US
dc.subject.scopusSpinal Fusion; Scoliosis; Patient Controlled Analgesiaen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosOrthopedicsen_US
dc.titleEffects of perioperatively administered bupivacaine and bupivacaine-methylprednisolone on pain after lumbar discectomyen_US
dc.typeArticle
dc.wos.quartileQ2 (Clinical neurology)en_US
dc.wos.quartileQ1 (Orthopedics)en_US

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