Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro

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dc.contributor.authorDimas, Konstantinos
dc.contributor.authorSakellaridis, Nikos
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorSarımahmut, Mehmet
dc.contributor.buuauthorGüney, Emel
dc.contributor.buuauthorYılmaz, Veysel T.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Klinik Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat/Kimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat/Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0003-2647-5875tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAG-8288-2021tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid44661687400tr_TR
dc.contributor.scopusid25027291500tr_TR
dc.contributor.scopusid7006269202tr_TR
dc.date.accessioned2021-11-16T13:19:25Z
dc.date.available2021-11-16T13:19:25Z
dc.date.issued2011-10
dc.description.abstractPurpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3). Methods Growth-inhibiting effcts have been tested by the MTT and ATP viability assays. Apoptosis has been detected by the caspase-cleaved cytokeratin 18 (M30-antigen) assay. Necrosis has been detected by staining the cells with fluorescent dyes. Mitotic index has been calculated by counting the mitotic figures after staining with hematoxylin. Results The complex 3 exhibited significant anti-growth effects, and its anti-growth effect was more powerful than that of cisplatin that is a standard chemotherapeutic agent for this type of cancer. The complexes did not induce apoptosis, while necrosis clearly took place. Conclusions Novel Pd(II) complex ([PdCl(terpy)] (sac).2H(2)O) seems to represent a potentially active drug against non-small cell lung cancer cell lines, and further studies in vivo are warranted.en_US
dc.identifier.citationUlukaya, E. vd. (2011). " Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro ". Journal of Cancer Research and Clinical Oncology, 137(10),1425-1434.en_US
dc.identifier.endpage1434tr_TR
dc.identifier.issn0171-5216
dc.identifier.issue10tr_TR
dc.identifier.pubmed21809029tr_TR
dc.identifier.scopus2-s2.0-80054759797tr_TR
dc.identifier.startpage1425tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00432-011-1021-1
dc.identifier.urihttps://link.springer.com/article/10.1007/s00432-011-1021-1
dc.identifier.urihttp://hdl.handle.net/11452/22667
dc.identifier.volume137tr_TR
dc.identifier.wos000295988800003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Cancer Research and Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectLung cancer treatmenten_US
dc.subjectPalladium(II) and platinum(II) complexesen_US
dc.subjectNecrosisen_US
dc.subjectCytotoxic activityen_US
dc.subjectCrystal-structureen_US
dc.subjectAntitumor agentsen_US
dc.subjectCisplatinen_US
dc.subjectPd(II)en_US
dc.subjectDnaen_US
dc.subjectApoptosisen_US
dc.subjectPt(II)en_US
dc.subjectAssayen_US
dc.subjectHepatotoxicityen_US
dc.subject.emtree3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromideen_US
dc.subject.emtreeAdenosine triphosphateen_US
dc.subject.emtreeCaspaseen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeCytokeratin 18en_US
dc.subject.emtreeFluorescent dyeen_US
dc.subject.emtreeHematoxylinen_US
dc.subject.emtreePalladium complexen_US
dc.subject.emtreePlatinum complexen_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer cell cultureen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCell deathen_US
dc.subject.emtreeCell viabilityen_US
dc.subject.emtreeConcentration responseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug potencyen_US
dc.subject.emtreeDrug structureen_US
dc.subject.emtreeEnzyme modificationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIC 50en_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeLung non small cell canceren_US
dc.subject.emtreeMitosis indexen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.meshAdenosine triphosphateen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCarcinoma, non-small-cell lungen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCisplatinen_US
dc.subject.meshHumansen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshMitosisen_US
dc.subject.meshNecrosisen_US
dc.subject.meshOrganometallic compoundsen_US
dc.subject.meshOrganoplatinum compoundsen_US
dc.subject.meshPalladiumen_US
dc.subject.scopusBenzisothiazole; Palladium; 2-Phenylpyridineen_US
dc.subject.wosOncologyen_US
dc.titleCell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitroen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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