Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondylitis
dc.contributor.author | İnal, Esra Erkol | |
dc.contributor.author | Görükmez, Orhan | |
dc.contributor.author | Eroğlu, Selma | |
dc.contributor.author | Solak, Özlem | |
dc.contributor.buuauthor | Görükmez, Özlem | |
dc.contributor.buuauthor | Topak, Ali | |
dc.contributor.buuauthor | Yakut, Tahsin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi//Tıbbi Genetik Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | HNQ-2791-2023 | tr_TR |
dc.contributor.scopusid | 57188923466 | tr_TR |
dc.contributor.scopusid | 55313334700 | tr_TR |
dc.contributor.scopusid | 6602802424 | tr_TR |
dc.date.accessioned | 2023-05-16T10:23:45Z | |
dc.date.available | 2023-05-16T10:23:45Z | |
dc.date.issued | 2015-06-27 | |
dc.description.abstract | Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin. The aim of this study is to clarify the relationships between susceptibility and severity of AS and GST-mu1 (GSTM1), GST-theta1 (GSTT1), GST-pi1 (GSTP1)-Ile105Val and angiotensin-converting enzyme (ACE) I/D polymorphisms in AS patients. One hundred thirty-eight AS patients and seventy-one healthy controls were enrolled in this study. Erythrocyte sedimentation rate and C-reactive protein (CRP) levels of the AS patients were recorded. The scores of the numeric rating scale (NRS) pain, the Bath Ankylosing Spondylitis Activity Index, the Bath Ankylosing Spondylitis Metrology Index and the Bath Ankylosing Spondylitis Functional Index were calculated. The genotypes distributions and allele frequencies of GSTM1, GSTT1, GSTP1-Ile105Val and ACE I/D polymorphisms were compared between patients and healthy controls. The Multiplex polymerase chain reaction (PCR) and the PCR-restriction fragment length polymorphism methods were used to detect the polymorphisms of ACE I/D, the GSTT1 and GSTM1 genes and the GSTP1-Ile105Val polymorphism, respectively. There were significantly higher levels of the GSTT1 null and the ACE II genotypes in AS patients compared to those in healthy controls (p = 0.002 and 0.005, respectively). We found significantly higher levels of CRP and the NRS pain scores in the patients with ACE ID or DD genotypes compared to those in the patients with ACE II genotypes (p = 0.005 and 0.035, respectively). The present results showed that genes involved in protection from oxidative stress and ACE gene may influence disease development and course in AS. | en_US |
dc.identifier.citation | İnal, E. E. vd. (2016). "Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondylitis". Rheumatology International, 36(1), 17-23. | en_US |
dc.identifier.endpage | 23 | tr_TR |
dc.identifier.issn | 0172-8172 | |
dc.identifier.issn | 1437-160X | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 26186891 | tr_TR |
dc.identifier.scopus | 2-s2.0-84953836295 | tr_TR |
dc.identifier.startpage | 17 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00296-015-3317-y | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00296-015-3317-y | |
dc.identifier.uri | http://hdl.handle.net/11452/32676 | |
dc.identifier.volume | 36 | tr_TR |
dc.identifier.wos | 000367808500003 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Rheumatology International | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Rheumatology | en_US |
dc.subject | GSTM1 | en_US |
dc.subject | GSTT1 | en_US |
dc.subject | GSTP1-Ile105Val | en_US |
dc.subject | ACE I/D | en_US |
dc.subject | Disease activity | en_US |
dc.subject | Disease severity | en_US |
dc.subject | Converting enzyme gene | en_US |
dc.subject | Insertion-deletion polymorphism | en_US |
dc.subject | Rheumatoid-arthritis | en_US |
dc.subject | Susceptibility | en_US |
dc.subject | Prevalence | en_US |
dc.subject | M1 | en_US |
dc.subject | T1 | en_US |
dc.subject | P1 | en_US |
dc.subject | Bath | en_US |
dc.subject.emtree | C reactive protein | en_US |
dc.subject.emtree | Isoleucine | en_US |
dc.subject.emtree | Valine | en_US |
dc.subject.emtree | Dipeptidyl carboxypeptidase | en_US |
dc.subject.emtree | Glutathione S-transferase M1 | en_US |
dc.subject.emtree | Glutathione S-transferase T1 | en_US |
dc.subject.emtree | Glutathione transferase | en_US |
dc.subject.emtree | Glutathione transferase P1 | en_US |
dc.subject.emtree | GSTP1 protein, human | en_US |
dc.subject.emtree | ACE gene | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Ankylosing spondylitis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bath ankylosing spondylitis activity index | en_US |
dc.subject.emtree | Bath ankylosing spondylitis functional index | en_US |
dc.subject.emtree | Bath ankylosing spondylitis metrology index | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Disease course | en_US |
dc.subject.emtree | Disease severity | en_US |
dc.subject.emtree | Erythrocyte sedimentation rate | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene | en_US |
dc.subject.emtree | Gene frequency | en_US |
dc.subject.emtree | Genetic association | en_US |
dc.subject.emtree | Genetic polymorphism | en_US |
dc.subject.emtree | Genetic susceptibility | en_US |
dc.subject.emtree | Genotype | en_US |
dc.subject.emtree | GSTM1 gene | en_US |
dc.subject.emtree | GSTP1 gene | en_US |
dc.subject.emtree | GSTT1 gene | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Multiplex polymerase chain reaction | en_US |
dc.subject.emtree | Oxidative stress | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rating scale | en_US |
dc.subject.emtree | Restriction fragment length polymorphism | en_US |
dc.subject.emtree | Turk (people) | en_US |
dc.subject.emtree | Allele | en_US |
dc.subject.emtree | Ankylosing spondylitis | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Case control study | en_US |
dc.subject.emtree | Genetic association study | en_US |
dc.subject.emtree | Genetic predisposition | en_US |
dc.subject.emtree | Genetics | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Single nucleotide polymorphism | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | C-reactive protein | en_US |
dc.subject.mesh | Case-control studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene frequency | en_US |
dc.subject.mesh | Genetic association studies | en_US |
dc.subject.mesh | Genetic predisposition to disease | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Glutathione S-transferase pi | en_US |
dc.subject.mesh | Glutathione transferase | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Oxidative stress | en_US |
dc.subject.mesh | Peptidyl-dipeptidase A | en_US |
dc.subject.mesh | Polymorphism, single nucleotide | en_US |
dc.subject.mesh | Spondylitis, ankylosing | en_US |
dc.subject.scopus | Anterior Cruciate Ligament; Gene; Tendinitis | en_US |
dc.subject.wos | Rheumatology | en_US |
dc.title | Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondylitis | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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