Fetal enflamatuar yanıt sendromu ve beyin zedelenmesi

dc.contributor.authorKumral, Abdullah
dc.contributor.authorYeşilırmak, Didem Cemile
dc.date.accessioned2020-02-12T06:37:41Z
dc.date.available2020-02-12T06:37:41Z
dc.date.issued2007
dc.description.abstractPreterm doğuma ve neonatal komplikasyonlara neden olan faktörler içerisinde en sık saptanan nedenlerin baflında intrauterin enfeksiyonve/veya enflamasyon gelmektedir. Mikroorganizma veya ürünlerinin fetusa ulaflması sitokin salınıflına ve sistemik fetal enflamatuar cevaba (FIRS) neden olmaktadır. FIRS; fetal veya neonatal beyin hasarına neden olarak ileride serebral palsi (CP) geliflimine yol açmaktadır. İntrauterin dönemde sitokinlerin neden olacağı beyaz cevher hasarı ve preterm doğum ile CP arasındaki iliflki günümüzde iyi bilinmektedir. Klinikte karflımıza periventriküler lökomalazi (PVL) olarak çıkan beyaz cevher hasarı, nörogeliflimsel prognoz ve CP’nin ağırlığı açısından oldukça önemlidirtr_TR
dc.description.abstractIntrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy (CP). A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.en_US
dc.identifier.citationKumral, A. ve Yeşilırmak, D. C. (2007). "Fetal enflamatuar yanıt sendromu ve beyin zedelenmesi". Güncel Pediatri, 5(1), 25-27.tr_TR
dc.identifier.endpage27tr_TR
dc.identifier.issn1304-9054
dc.identifier.issn1308-6308
dc.identifier.issue1tr_TR
dc.identifier.startpage25tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/909239
dc.identifier.urihttp://hdl.handle.net/11452/8657
dc.identifier.volume5tr_TR
dc.language.isotrtr_TR
dc.publisherUludağ Üniversitesitr_TR
dc.relation.journalGüncel Pediatri / The Journal of Current Pediatricstr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFetal enflamatuar yanıt sendromutr_TR
dc.subjectBeyin hasarıtr_TR
dc.subjectFetal inflammatory response syndromeen_US
dc.subjectBrain injuryen_US
dc.titleFetal enflamatuar yanıt sendromu ve beyin zedelenmesitr_TR
dc.title.alternativeFetal inflammatory response syndrome and brain damageen_US
dc.typeArticleen_US

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