Expression of p16 in serous ovarian neoplasms

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dc.contributor.buuauthorNazlıoğlu, Hülya Öztürk
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorBilgin, Tufan
dc.contributor.buuauthorÖzuysal, Sema
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patololoji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.scopusid57197115377tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid7004103925tr_TR
dc.contributor.scopusid56616314600tr_TR
dc.date.accessioned2022-06-24T11:23:53Z
dc.date.available2022-06-24T11:23:53Z
dc.date.issued2010
dc.description.abstractPurpose: We aimed to examine p16 protein expression in ovarian serous neoplasms along with normal ovarian tissues. Materials and Methods: p16 expression was immunhistochemically evaluated in 86 ovarian serous neoplasms (21 cystadenomas, 20 borderline tumors and 45 carcinomas) and 21 non-neoplastic ovarian tissue. The results were also compared with histopathological grade in serous adenocarcinomas. Results: p16 expression rates for benign, borderline ovarian tumors and ovarian cancer were 14.2%, 85% and 86.6%, respectively. It was significantly higher in carcinomas (p < 0.001) and borderline tumors (p < 0.001) compared to cystadenomas. No immunoreactivity was found in the non-neoplastic ovarian surface epithelial cells. The percentage of p16 expression did not change significantly with histological grade in carcinomas. Conclusion: p16 expression is strong and widespread involving most tumor cells in serous papillary ovarian carcinomas, and is probably an early event.en_US
dc.identifier.citationNazlıoğlu, H. Ö. vd. (2010). "Expression of p16 in serous ovarian neoplasms". European Journal of Gynaecological Oncology, 31(3), 312-314.en_US
dc.identifier.endpage314tr_TR
dc.identifier.issn0392-2936
dc.identifier.issue3tr_TR
dc.identifier.pubmed21077476tr_TR
dc.identifier.scopus2-s2.0-77954136163tr_TR
dc.identifier.startpage312tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/27382
dc.identifier.volume31tr_TR
dc.identifier.wos000278092900014tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherIMR Pressen_US
dc.relation.journalEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectp16en_US
dc.subjectImmunohistochemistryen_US
dc.subjectOvarian serous carcinomaen_US
dc.subjectBorderline tumoren_US
dc.subjectCystadenomaen_US
dc.subjectHigh-frequencyen_US
dc.subjectCarcinomaen_US
dc.subjectP16(INK4A)en_US
dc.subjectOverexpressionen_US
dc.subjectTumorsen_US
dc.subjectMethylationen_US
dc.subjectProteinen_US
dc.subjectCanceren_US
dc.subjectGenesen_US
dc.subjectAbnormalitiesen_US
dc.subjectOncologyen_US
dc.subjectObstetrics & gynecologyen_US
dc.subject.emtreeProtein p16en_US
dc.subject.emtreeAdenocarcinomaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer gradingen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCystadenomaen_US
dc.subject.emtreeEpithelium cellen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeImmunoreactivityen_US
dc.subject.emtreeOvary carcinomaen_US
dc.subject.emtreeOvary serous carcinomaen_US
dc.subject.emtreeOvary tumoren_US
dc.subject.emtreeProtein expressionen_US
dc.subject.meshCystadenocarcinoma, serousen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNeoplasm proteinsen_US
dc.subject.meshOvarian neoplasmsen_US
dc.subject.scopusCyclin Dependent Kinase Inhibitor 2A; P16 Genes; Reading Framesen_US
dc.subject.wosOncologyen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleExpression of p16 in serous ovarian neoplasmsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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