Propolis ameliorates human peripheral blood lymphocytes from DNA damage caused by Aflatoxin B1

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dc.contributor.authorTürkez, Hasan
dc.contributor.authorYousef, Mokhtar I.
dc.date.accessioned2021-03-08T07:21:43Z
dc.date.available2021-03-08T07:21:43Z
dc.date.issued2009
dc.description.abstractPropolis, a natural product derived from plant resins collected by honeybees, has been used for thousands of years in traditional medicine all over the world. Its components are strong antioxidants and free radical scavengers. On the other hand, aflatoxin B1 (AFB1) is the most potent pulmonary and hepatic carcinogen. Since the eradication of AFB1 contamination in agricultural products has been difficult, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. The biological effects of propolis are known, but its interaction with AFB1 is not known for therapeutic uses. Therefore, this study was designed to examine the protective effects of different concentrations of propolis (6.25, 12.5, 25, 50 and 100 mg/L) against AFB1 (3.12 ppm) genotoxicity in human lymphocytes in vitro. The genotoxic effects were assessed by micronucleus (MN) test in human blood cultures. The results of the present study indicated that AFB1 significantly (P<0.05) increased formations of MNs in peripheral lymphocytes as compared to controls. On the contrary, propolis alone did not show genotoxic effects at the concentrations tested. Furthermore, AFB1-induced increases in the genotoxicity indices were diminished by the addition of propolis. This anti-mutagenic effect of propolis can be attributed to its powerful scavenger ability.en_US
dc.identifier.citationTürkez, H. ve Yousef, M. I. (2009). "Propolis ameliorates human peripheral blood lymphocytes from DNA damage caused by Aflatoxin B1". Journal of Biological and Environmental Sciences, 3(9), 77-80.tr_TR
dc.identifier.endpage80tr_TR
dc.identifier.issn1307-9530
dc.identifier.issn1308-2019
dc.identifier.issue9tr_TR
dc.identifier.startpage77tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/497795
dc.identifier.urihttp://hdl.handle.net/11452/17206
dc.identifier.volume3tr_TR
dc.language.isoenen_US
dc.publisherUludağ Üniversitesitr_TR
dc.relation.journalJournal of Biological and Environmental Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAflatoxin B1tr_TR
dc.subjectMicronucleus assayen_US
dc.subjectAntimutagenicityen_US
dc.subjectIn vitroen_US
dc.subjectLymphocytesen_US
dc.subjectPropolisen_US
dc.titlePropolis ameliorates human peripheral blood lymphocytes from DNA damage caused by Aflatoxin B1en_US
dc.typeArticleen_US

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2009 Cilt 3 Sayı 9