Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women

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dc.contributor.authorKaya, Hakan
dc.contributor.authorÖzkaya, Okan
dc.contributor.authorSezik, Mekin
dc.contributor.authorArslanoğlu, Evrim
dc.contributor.buuauthorYılmaztepe, Arzu
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.scopusid8606136100tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.date.accessioned2022-01-06T08:16:54Z
dc.date.available2022-01-06T08:16:54Z
dc.date.issued2005-03-14
dc.description.abstractObjective: To investigate the relationship between raloxifene administration and serum malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPx) levels in healthy postmenopausal women. Methods: In a randomized and placebo-controlled design, 80 women received either 60 mg/day raloxifene or placebo for 24 weeks. MDA, SOD, and GPx levels were assessed at 0,4,12, and 24 weeks. Wilcoxon signed-rank test and Mann-Whitney U test were used for comparisons. Results: Six women in the treatment arm and eight women in the placebo group discontinued the study. Mean serum MDA levels were significantly (p = 0.001) decreased from 11.4 nmol/ml at baseline to 8.9 nmol/ml at week 12 with raloxifene treatment. Mean erythrocyte SOD activity was significantly (p = 0.02) reduced from 1472 U/g Hb at baseline to 1173 U/g Hb at week 12 following raloxifene administration. Lowered serum MDA and erythrocyte SOD levels persisted during treatment. On contrary, erythrocyte GPx levels did not change significantly with raloxifene administration. Conclusions: Raloxifene (60 mg/day) lowers serum MDA levels and erythrocyte SOD activity in postmenopausal women after 12 weeks of treatment. The clinical implications of these findings need to be determined.en_US
dc.identifier.citationKaya, H. vd. (2005). "Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women". Maturitas, 50(3), 182-188.en_US
dc.identifier.endpage188tr_TR
dc.identifier.issn0378-5122
dc.identifier.issn1873-4111
dc.identifier.issue3tr_TR
dc.identifier.pubmed15734599tr_TR
dc.identifier.scopus2-s2.0-13944274553tr_TR
dc.identifier.startpage182tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.maturitas.2004.05.005
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378512204001744#!
dc.identifier.urihttps://www.maturitas.org/article/S0378-5122(04)00174-4/fulltext
dc.identifier.urihttp://hdl.handle.net/11452/23888
dc.identifier.volume50tr_TR
dc.identifier.wos000227663700005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalMaturitasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeriatrics & gerontologyen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectRaloxifeneen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectAntioxidanten_US
dc.subjectEstrogen-receptor modulatoren_US
dc.subjectCoronary-heart-diseaseen_US
dc.subjectNitric-oxideen_US
dc.subjectOvariectomized ratsen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectIn-vitroen_US
dc.subjectReplacementen_US
dc.subjectBrainen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeRaloxifeneen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIntermethod comparisonen_US
dc.subject.emtreeNormal humanen_US
dc.subject.emtreePostmenopauseen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeRank sum testen_US
dc.subject.emtreeStatistical analysisen_US
dc.subject.emtreeStatistical significanceen_US
dc.subject.scopusConjugated Estrogens; Diarylpropionitrile; Estradiolen_US
dc.subject.wosGeriatrics & gerontologyen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleEffects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal womenen_US
dc.typeArticle
dc.wos.quartileQ2 (Obstetrics & gynecology)en_US
dc.wos.quartileQ3en_US

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