Use of phosphatide precursors to promote synaptogenesis

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dc.contributor.authorWurtman, Richard J.
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2021-10-27T07:31:28Z
dc.date.available2021-10-27T07:31:28Z
dc.date.issued2009
dc.description.abstractNew brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are depleted in Alzheimer's disease,as are some circulating compounds needed for synthesizing phosphatides, the major constituents of synaptic membranes. Animals given three of these compounds, all nutrients-uridine, the omega-3 polyunsaturated fatty acid docosahexaenoic acid, and choline-develop increased levels of brain phosphatides and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved cognition, and enhanced neurotransmitter release. The nutrients work by increasing the substrate-saturation of low-affinity enzymes that synthesize the phosphatides. Moreover, uridine and its nucleotide metabolites activate brain P2Y receptors, which control neuronal differentiation and synaptic protein synthesis. A preparation containing these compounds is being tested for treating Alzheimer's disease.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAen_US
dc.description.sponsorshipCenter for Brain Sciences and Metabolism Charitable Trusten_US
dc.identifier.citationWurtman, R. J. vd. (2009). "Use of phosphatide precursors to promote synaptogenesis". Annual Review of Nutrition, 29, 59-87.en_US
dc.identifier.endpage87tr_TR
dc.identifier.issn0199-9885
dc.identifier.pubmed19400698tr_TR
dc.identifier.scopus2-s2.0-67749111670tr_TR
dc.identifier.startpage59tr_TR
dc.identifier.urihttps://doi.org/10.1146/annurev-nutr-080508-141059
dc.identifier.urihttps://www.annualreviews.org/doi/10.1146/annurev-nutr-080508-141059
dc.identifier.urihttp://hdl.handle.net/11452/22495
dc.identifier.volume29tr_TR
dc.identifier.wos000270118600004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosBKCISen_US
dc.language.isoenen_US
dc.publisherAnnual Reviewsen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalAnnual Review of Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitionen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectPhosphatideen_US
dc.subjectDendritic spineen_US
dc.subjectSynaptic membraneen_US
dc.subjectP2Y receptorsen_US
dc.subjectFatty-acid-compositionen_US
dc.subjectCtp-phosphocholine cytidylyltransferaseen_US
dc.subjectPlasma choline concentrationsen_US
dc.subjectPlus docosahexaenoic aciden_US
dc.subjectRat sympathetic neuronsen_US
dc.subjectBrain-barrier transporten_US
dc.subjectAlpha-linolenic aciden_US
dc.subjectHamster ovary cellsen_US
dc.subjectCdp-cholineen_US
dc.subjectAlzheimers-diseaseen_US
dc.subjectNutrition & dieteticsen_US
dc.subjectAnimaliaen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCyanocobalaminen_US
dc.subject.emtreeDocosahexaenoic aciden_US
dc.subject.emtreeFolic aciden_US
dc.subject.emtreePhospholipiden_US
dc.subject.emtreePostsynaptic density protein 95en_US
dc.subject.emtreePurinergic P2Y receptoren_US
dc.subject.emtreePyridoxineen_US
dc.subject.emtreeSouvenaiden_US
dc.subject.emtreeSynapsin Ien_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUridineen_US
dc.subject.emtreeAlzheimer diseaseen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeCognitionen_US
dc.subject.emtreeDendritic spineen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNerve endingen_US
dc.subject.emtreeNeurotransmitter releaseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePhospholipid synthesisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeSynapseen_US
dc.subject.emtreeSynaptic membraneen_US
dc.subject.emtreeSynaptogenesisen_US
dc.subject.meshAlzheimer diseaseen_US
dc.subject.meshCholineen_US
dc.subject.meshDocosahexaenoic acidsen_US
dc.subject.meshHumansen_US
dc.subject.meshPhospholipidsen_US
dc.subject.meshProdrugsen_US
dc.subject.meshSynapsesen_US
dc.subject.meshSynaptic transmissionen_US
dc.subject.meshUridineen_US
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicolineen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleUse of phosphatide precursors to promote synaptogenesisen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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