Antipyretic effect of ketoprofen

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dc.contributor.authorAygün, Denizmen A.
dc.contributor.authorArısoy, Emin Sami
dc.contributor.authorSeringeç, Murat
dc.contributor.buuauthorÇelebi, Solmaz
dc.contributor.buuauthorHacımustafaoğlu, Mustafa Kemal
dc.contributor.buuauthorKaralı, Yasin
dc.contributor.buuauthorAkgöz, Semra
dc.contributor.buuauthorKurt, Ayşegül Neşe Çıtak
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid7006095295tr_TR
dc.contributor.scopusid49863694000tr_TR
dc.contributor.scopusid6602154166tr_TR
dc.contributor.scopusid14061863400tr_TR
dc.contributor.scopusid36152868000tr_TR
dc.date.accessioned2021-12-06T10:28:24Z
dc.date.available2021-12-06T10:28:24Z
dc.date.issued2009-03
dc.description.abstractObjective. To investigate the efficacy and side effect of ketoprofen as well as compliance with respect to the taste of the drug and compare these parameters with those of acetaminophen and ibuprofen. Methods. A total of 301 patients between 1-14 years of age who attended to emergency rooms of three medical centers with the complaint of fever that required antipyretic therapy were included in the study. Fever was measured with the aid of a tympanic thermometer (Braun Kronberg 6014) and followed for 4-6 hours. The measurement was repeated at 30, 60, 120 minutes, and again 4-6 hours after the initial assessment. Results. The mean age of the patients was 47.8 +/- 41.1 months. The patients randomly received 15 mg/kg/dose of acetaminophen (n=112 group 1), 0.5 mg/kg/dose of ketoprofen (n=105, group 2), or 10 mg/kg/dose of ibuprofen (n=84, group 3). Temperature records in three groups was 38.4 +/- 0.7 degrees C, 38.4 +/- 0.7 degrees C, and 38.5 +/- 0.5 degrees C at 30 minutes; 38.0 +/- 0.7 degrees C, 37.9 +/- 0.7 degrees C, and 38.0 +/- 0.6 degrees C at 60 minutes (p > 0.05), 37.7 +/- 0.6 degrees C, 37.6 +/- 0.7 degrees C, and 37.7 +/- 0.5 degrees C at 120 minutes (p > 0.05); 37.5 +/- 0.7 degrees C, 37.3 +/- 0.6 degrees C, and 37.4 +/- 0.6 degrees C at 4-6 hours after admission (P > 0.05) respectively. The fever was significantly lower at 30, 60, and 120 minutes in all groups (p < 0.05) respectively. Early vomiting after medication (< 6 hours) was observed in 3.8%, 13.5%, and 9.6% respectively whereas late vomiting (6-48 hours) occurred in 1.3%, 2.7%, and 5.8% respectively (p > 0.05). Bad taste was expressed by 5.1%, 12.2%, and 5.8% early (< 6 hours), and 3.9%, 8.1%, and 3.8% late (6-48 hours) (p > 0.05). There were no differences between age groups for antipyretic effect, taste and adverse effect in three drugs (p > 0.05). Conclusion. All three drugs were similar in terms of efficacy, adverse effects, and compliance within 48 hours of therapy. These results suggest that ketoprofen may be used for antipyresis as an alternative to acetaminophen and ibuprofen.en_US
dc.identifier.citationÇelebi, S. vd. (2009). "Antipyretic effect of ketoprofen". Indian Journal of Pediatrics, 76(3), 287-291.en_US
dc.identifier.endpage291tr_TR
dc.identifier.issn0019-5456
dc.identifier.issue3tr_TR
dc.identifier.pubmed19129989tr_TR
dc.identifier.scopus2-s2.0-64249157648tr_TR
dc.identifier.startpage287tr_TR
dc.identifier.urihttps://doi.org/10.1007/s12098-008-0234-z
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12098-008-0234-z
dc.identifier.urihttp://hdl.handle.net/11452/23005
dc.identifier.volume76tr_TR
dc.identifier.wos000264923900007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalIndian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetaminophenen_US
dc.subjectChildrenen_US
dc.subjectFeveren_US
dc.subjectIbuprofenen_US
dc.subjectKetoprofenen_US
dc.subjectPharmacokineticsen_US
dc.subjectChildrenen_US
dc.subjectBlinden_US
dc.subjectPediatricsen_US
dc.subject.emtreeIbuprofenen_US
dc.subject.emtreeKetoprofenen_US
dc.subject.emtreeParacetamolen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAlternative medicineen_US
dc.subject.emtreeAntipyretic activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeCompliance (physical)en_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeEmergency warden_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFeveren_US
dc.subject.emtreeGroups by ageen_US
dc.subject.emtreeHealth centeren_US
dc.subject.emtreeHospital admissionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeTaste disorderen_US
dc.subject.emtreeTemperature measurementen_US
dc.subject.emtreeTympanic thermometeren_US
dc.subject.emtreeVomitingen_US
dc.subject.meshAcetaminophenen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnalgesics, non-narcoticen_US
dc.subject.meshAnalysis of varianceen_US
dc.subject.meshAnti-inflammatory agents, non-steroidalen_US
dc.subject.meshBody temperatureen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshFeveren_US
dc.subject.meshHumansen_US
dc.subject.meshIbuprofenen_US
dc.subject.meshInfanten_US
dc.subject.meshKetoprofenen_US
dc.subject.meshMaleen_US
dc.subject.meshTime factorsen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusKetoprofen; Nonsteroid Antiinflammatory Agent; Narcotic Analgesic Agenten_US
dc.subject.wosPediatricsen_US
dc.titleAntipyretic effect of ketoprofenen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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