Microsatellite instability status affects gene expression profiles in early onset colorectal cancer patients

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dc.contributor.authorZorluoǧlu, Abdullah
dc.contributor.buuauthorAk, Seçil
dc.contributor.buuauthorTunca, Berrin Türkei
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorÖztürk, Ersin
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorErtürk, Elif
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridF-8554-2017tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridAAK-3371-2021tr_TR
dc.contributor.scopusid55253485700tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid6701800362tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid35070171400tr_TR
dc.contributor.scopusid6603810549tr_TR
dc.contributor.scopusid50261655300tr_TR
dc.date.accessioned2023-05-17T12:49:20Z
dc.date.available2023-05-17T12:49:20Z
dc.date.issued2013-12
dc.description.abstractBackground: The association between microsatellite instability (MSI) status and gene expression profiles in the early onset sporadic colorectal cancer (CRC) has not been clearly established. The aim of this study was to identify the altered gene expression patterns depending on the MSI status of early onset CRC and determine specific biomarkers that could provide novel therapeutic molecular targets in the Turkish population. Materials and methods: MSI markers (BAT25, BAT26, D2S123, D5S346, and D17S250) were investigated in tumors from 36 early onset sporadic CRC patients in whom gene expression profiles were analyzed previously. The relationship between the gene expression profiles depending on MSI status was evaluated. Results: A total of 15 tumors (16.66%) were identified as having MSI and 21 tumors (58.33%) were identified as having microsatellite stability (MSS). CK20 and MAP3K8 upregulation, observed in MSS tumors, was significantly associated with lymph node metastasis, recurrence, and/or distant metastasis and a short median survival (P < 0.05). REG1A upregulation is also correlated with recurrence and/or distant metastasis and a short median survival in patients with MSI tumors (P < 0.05). Conclusions: High expression levels of CK20 and MAP3K8 in MSS tumors and REG1A in MSI tumors correlated with a poor prognosis in CRC patients. Further studies and validations are required; these genes may provide novel therapeutic molecular targets for the development of anticancer drugs related to MSI status for early onset CRC treatment.tr_TR
dc.identifier.citationAk, S. vd. (2013). “Microsatellite instability status affects gene expression profiles in early onset colorectal cancer patients”. Journal of Surgical Research, 185(2), 626-637.tr_TR
dc.identifier.endpage637tr_TR
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2tr_TR
dc.identifier.pubmed23992855tr_TR
dc.identifier.scopus2-s2.0-84891668986tr_TR
dc.identifier.startpage626tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jss.2013.07.014
dc.identifier.urihttp://hdl.handle.net/11452/32702
dc.identifier.volume185tr_TR
dc.identifier.wos000326938500047tr_TR
dc.indexed.pubmedPubMedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherElseviertr_TR
dc.relation.bapUAP(T)-2012/1tr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Surgical Researchtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectSurgerytr_TR
dc.subjectColorectal cancertr_TR
dc.subjectMSItr_TR
dc.subjectMSStr_TR
dc.subjectCK20tr_TR
dc.subjectMAP3K8tr_TR
dc.subjectREG1Atr_TR
dc.subjectEarly onsettr_TR
dc.subjectMessenger-rna expressiontr_TR
dc.subjectReg-ivcytokeratin-20tr_TR
dc.subjectCarcinomastr_TR
dc.subjectOverexpressiontr_TR
dc.subjectIdentificationtr_TR
dc.subjectChemotherapytr_TR
dc.subjectAlphatr_TR
dc.subjectDnatr_TR
dc.subjectDifferentiationtr_TR
dc.subjectColorectal cancertr_TR
dc.subjectEarly onsettr_TR
dc.subject.emtreeBiological markertr_TR
dc.subject.emtreeCytokeratin 20tr_TR
dc.subject.emtreeLithostathinetr_TR
dc.subject.emtreeMAP3K8 protein, humantr_TR
dc.subject.emtreeMitogen activated protein kinase kinase kinasetr_TR
dc.subject.emtreeOncoproteintr_TR
dc.subject.emtreeREG1A protein, humantr_TR
dc.subject.emtreeTranscriptometr_TR
dc.subject.emtreeGenetic markertr_TR
dc.subject.emtreeAdulttr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBAT25 genetr_TR
dc.subject.emtreeBAT26 genetr_TR
dc.subject.emtreeCancer patienttr_TR
dc.subject.emtreeCancer prognosistr_TR
dc.subject.emtreeCancer recurrencetr_TR
dc.subject.emtreeCarcinogenesistr_TR
dc.subject.emtreeCK20 genetr_TR
dc.subject.emtreeClinical articletr_TR
dc.subject.emtreeColorectal cancertr_TR
dc.subject.emtreeColorectal carcinogenesistr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeD17S250 genetr_TR
dc.subject.emtreeD2S123 genetr_TR
dc.subject.emtreeD5S346 genetr_TR
dc.subject.emtreeDistant metastasistr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeFollow uptr_TR
dc.subject.emtreeGenetr_TR
dc.subject.emtreeGene expression profilingtr_TR
dc.subject.emtreeHereditytr_TR
dc.subject.emtreeHumantr_TR
dc.subject.emtreeHuman tissuetr_TR
dc.subject.emtreeLymph node metastasistr_TR
dc.subject.emtreeMaletr_TR
dc.subject.emtreeMAP3K8 genetr_TR
dc.subject.emtreeMicrosatellite instabilitytr_TR
dc.subject.emtreeMicrosatellite markertr_TR
dc.subject.emtreeMicrosatellite stabilitytr_TR
dc.subject.emtreeMiddle agedtr_TR
dc.subject.emtreePopulation genetic parameterstr_TR
dc.subject.emtreePriority journaltr_TR
dc.subject.emtreeREG1A genetr_TR
dc.subject.emtreeSurvivaltr_TR
dc.subject.emtreeTurkey (republic)tr_TR
dc.subject.emtreeUpregulationtr_TR
dc.subject.emtreeYoung adulttr_TR
dc.subject.emtreeAdolescenttr_TR
dc.subject.emtreeCK20tr_TR
dc.subject.emtreeColorectal cancertr_TR
dc.subject.emtreeColorectal tumortr_TR
dc.subject.emtreeDNA methylationtr_TR
dc.subject.emtreeEarly onsettr_TR
dc.subject.emtreeGene expression regulationtr_TR
dc.subject.emtreeGenetic markertr_TR
dc.subject.emtreeGenetic screeningtr_TR
dc.subject.emtreeGeneticstr_TR
dc.subject.emtreeLymph node metastasistr_TR
dc.subject.emtreeMAP3K8tr_TR
dc.subject.emtreeMetastasistr_TR
dc.subject.emtreeMortalitytr_TR
dc.subject.emtreeMSItr_TR
dc.subject.emtreeMSStr_TR
dc.subject.emtreeOnset agetr_TR
dc.subject.emtreePrognosistr_TR
dc.subject.emtreeREG1Atr_TR
dc.subject.emtreeColorectal tumortr_TR
dc.subject.emtreeSecondarytr_TR
dc.subject.meshAdolescenttr_TR
dc.subject.meshAdulttr_TR
dc.subject.meshAge of onsettr_TR
dc.subject.meshColorectal neoplasmstr_TR
dc.subject.meshDNA methylationtr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshGene expression regulation, neoplastictr_TR
dc.subject.meshGenetic markerstr_TR
dc.subject.meshGenetic testingtr_TR
dc.subject.meshHumanstr_TR
dc.subject.meshKeratin-20tr_TR
dc.subject.meshLithostathinetr_TR
dc.subject.meshLymphatic metastasistr_TR
dc.subject.meshMaletr_TR
dc.subject.meshMAP kinase kinase kinasestr_TR
dc.subject.meshMicrosatellite instabilitytr_TR
dc.subject.meshMiddle agedtr_TR
dc.subject.meshPrognosistr_TR
dc.subject.meshProto-oncogene proteinstr_TR
dc.subject.meshTranscriptometr_TR
dc.subject.meshYoung adulttr_TR
dc.subject.scopusInferior Mesenteric Artery; Complete; Lymph Node Dissectiontr_TR
dc.subject.wosSurgerytr_TR
dc.titleMicrosatellite instability status affects gene expression profiles in early onset colorectal cancer patientstr_TR
dc.typeArticle
dc.wos.quartileQ3tr_TR

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