Capecitabine-induced cardiotoxicity mimicking myocardial infarction

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Date

2009-08

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Bohn Stafleu van Loghum

Abstract

Capecitabine, a fluoropyrimidine derivative, is an orally administered drug that delivers 5-fluorouracil (5-FU) selectively to the tumour. The drug has demonstrated activity in metastatic colorectal cancer. We describe a male patient receiving capecitabine therapy with typical chest pain and electrocardiographic changes consistent with ST-segment elevation myocardial infarction. Capecitabine-induced cardiotoxicity may develop in patients who have had a previous episode of 5-FU-induced cardiotoxicity. Capecitabine-induced cardiotoxicity is a rare condition that may lead to diagnostic and therapeutic dilemmas.

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Keywords

Capecitabine, Cardiotoxicity, Myocardial infarction, Cardiovascular system & cardiology

Citation

Şentürk, T. vd. (2009). "Capecitabine-induced cardiotoxicity mimicking myocardial infarction". Netherlands Heart Journal, 17(7-8), 277-280.