Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease

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dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorAslan, Kemal
dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorSarandol, Emre
dc.contributor.buuauthorYeşilbursa, Dilek
dc.contributor.buuauthorSerdar, Akın
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0909-618Xtr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.contributor.researcheridAAH-6200-2021tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.date.accessioned2021-08-19T12:41:35Z
dc.date.available2021-08-19T12:41:35Z
dc.date.issued2006-02-21
dc.description.abstractObjectives: We aimed to evaluate the association of lipid peroxidation, protein oxidation and antioxidant system, and to assess an association with the severity of the disease, in patients with and without coronary artery disease (CAD) documented by coronary angiography. Design and methods: The population included 208 patients, undergoing clinically indicated coronary angiography. While the subjects with normal coronary angiograms (n = 54) were evaluated as controls, the patients with CAD (n = 154) were divided into three categories according to the number of diseased coronaries; one-vessel (n = 50), two-vessels (n = 51) and three-vessels (n = 53). Lipid parameters were determined by routine laboratory methods. Plasma malondialdehyde and vitamin E concentrations were determined with the high-performance liquid chromatography. Other oxidant and antioxidant parameters were studied spectrophotometrically. Results: While plasma malondialdehyde levels, the susceptibilities of erythrocyte and apolipoprotein B containing lipoproteins to in vitro induced oxidative stress, serum protein carbonyls, low density lipoprotein-cholesterol, triglyceride, apolipoprotein B and lipoprotein (a) levels had significantly increased, high-density lipoprotein-cholesterol and apolipoprotein AI levels, erythrocyte glutathione peroxidase, glutathione reductase, glucose 6 phosphate debydrogenase, serum catalase, paraoxonase and arylesterase activities, plasma vitamin E and C and carotenoid levels had significantly decreased. The odds ratios for one-, two-, and three-vessel disease increased across especially higher tertiles of concentrations for oxidation parameters and lower tertiles of concentrations for antioxidant parameters. Conclusions: According to the results, we suggest that increased lipid and protein oxidation products and decreased antioxidant enzymes and vitamins contribute to increased oxidative stress which in turn is related to the severity of the disease.en_US
dc.identifier.citationSerdar, Z. vd. (2006). ''Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease''. Clinical Biochemistry, 39(8), 794-803.en_US
dc.identifier.endpage803tr_TR
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.issue8tr_TR
dc.identifier.pubmed16600205tr_TR
dc.identifier.scopus2-s2.0-33746911144tr_TR
dc.identifier.startpage794tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2006.02.004
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912006000531
dc.identifier.urihttp://hdl.handle.net/11452/21478
dc.identifier.volume39tr_TR
dc.identifier.wos000240087300004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.journalClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectAscorbic-aciden_US
dc.subjectCoronary artery diseaseen_US
dc.subjectBeta-caroteneen_US
dc.subjectLipid peroxidationen_US
dc.subjectHeart-diseaseen_US
dc.subjectProtein oxidationen_US
dc.subjectVitamin-e consumptionen_US
dc.subjectAntioxidantsen_US
dc.subjectSerum paraoxonase arylesteraseen_US
dc.subjectParaoxonaseen_US
dc.subjectPlasmaen_US
dc.subjectPeroxidationen_US
dc.subjectAlpha-tocopherolen_US
dc.subjectEnzyme-activityen_US
dc.subjectAscorbic-aciden_US
dc.subjectSerum paraoxonase arylesteraseen_US
dc.subject.scopusAryldialkylphosphatase; Arylesterase; Human PON1 Proteinen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleLipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery diseaseen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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