Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal

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dc.contributor.authorLevendusky, Mark C.
dc.contributor.authorHamilton, Jacob R.
dc.contributor.authorMillington, William
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.date.accessioned2021-09-09T08:40:38Z
dc.date.available2021-09-09T08:40:38Z
dc.date.issued2006-01-13
dc.description.abstractGlycyl-glutamine (Gly-Gln) is an inhibitory dipeptide synthesized from beta-endorphin(1-31). Previously, we showed that Gly-Gln inhibits morphine conditioned place preference, tolerance, dependence and withdrawal. In this study, we tested whether Gly-Gln's inhibitory activity extends to other rewarding drugs, specifically nicotine. Rats were conditioned with nicotine (0.6 mg/kg, s.c.) for four days and tested on day five. Glycyl-glutamine (100 nmol i.c.v.) inhibited acquisition and expression of a nicotine place preference significantly. Cyclo(Gly-Gln) (100 nmol i.c.v. or 25 mg/kg i.p.), a cyclic Gly-Gln derivative, blocked expression of nicotine place preference but Gly-D-Gln (100 nmol i.c.v.) was ineffective. To study nicotine withdrawal, rats were treated with nicotine (9 mg/kg/day) for seven days and conditioned place aversion was induced with mecamylamine (1 mg/kg, s.c.). Glycyl-glutamine blocked acquisition of place aversion to mecamylamine but not U50,488, a kappa opioid receptor agonist. Glycyl-glutamine thus inhibits the rewarding effects of nicotine and attenuates withdrawal in nicotine dependent rats.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Drug Abuse (NIDA) European Commission-R41DA018029.tr_TR
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Drug Abuse (NIDA)-DA018029.tr_TR
dc.identifier.citationGöktalay, G. vd. (2006). ''Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal''. European Journal of Pharmacology, 530(1-2), 95-102.en_US
dc.identifier.endpage102tr_TR
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue1-2tr_TR
dc.identifier.pubmed16364288tr_TR
dc.identifier.scopus2-s2.0-29844452534tr_TR
dc.identifier.startpage95tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2005.11.034
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299905012203
dc.identifier.urihttp://hdl.handle.net/11452/21798
dc.identifier.volume530tr_TR
dc.identifier.wos000234704700013tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectConditioned place preferenceen_US
dc.subjectPro-opiomelanocortinen_US
dc.subjectDipeptideen_US
dc.subjectBeta-endorphinen_US
dc.subjectNicotineen_US
dc.subjectOpioiden_US
dc.subjectNaloxoneen_US
dc.subjectDependenceen_US
dc.subjectReceptoren_US
dc.subjectSmokingen_US
dc.subjectNaltrexoneen_US
dc.subjectCyclic dipeptidesen_US
dc.subjectOligopeptide transporteren_US
dc.subjectCardiorespiratory depressionen_US
dc.subjectBeta-endorphinen_US
dc.subjectNaturally-occurring antagonisten_US
dc.subject.scopusAging; Amoxicillin; Contractility Invitroen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleGlycyl-glutamine inhibits nicotine conditioned place preference and withdrawalen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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