Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements

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dc.contributor.buuauthorGurbet, Alp
dc.contributor.buuauthorBasağan, Moğol, E.
dc.contributor.buuauthorTürker, Gürkan
dc.contributor.buuauthorÖzcan, Berin
dc.contributor.buuauthorKaya, E. K.
dc.contributor.buuauthorUğun, Fatih
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6503-8232tr_TR
dc.contributor.orcid0000-0002-3019-581Xtr_TR
dc.contributor.orcid0000-0002-3019-581Xtr_TR
dc.contributor.researcheridAAI-6642-2021tr_TR
dc.contributor.researcheridA-7994-2018tr_TR
dc.contributor.scopusid35618853300tr_TR
dc.contributor.scopusid23982134100tr_TR
dc.contributor.scopusid7003400116tr_TR
dc.contributor.scopusid49762562600tr_TR
dc.contributor.scopusid7003619647tr_TR
dc.contributor.scopusid6603825848tr_TR
dc.date.accessioned2021-08-16T07:05:56Z
dc.date.available2021-08-16T07:05:56Z
dc.date.issued2006
dc.description.abstractPurpose: This prospective, randomized, double-blind study was designed to assess whether intraoperative infusion of dexmedetomidine provides effective postoperative analgesia. Postoperative pain scores and morphine consumption were compared in a treated group and a placebo group, both of which received patient-controlled morphine after total abdominal hysterectomy. Methods: Fifty women were randomly assigned to two groups. Group D (n = 25) received a loading dose of dexmedetomidine 1 mu g(.)kg(-1) iv during induction of anesthesia, followed by a continuous infusion at a rate of 0.5 mu g(.)kg(-1.)hr(-1) throughout the operation. Group P (n = 25) received a volume-matched bolus and infusion of placebo (0.9% saline). For each case, heart rate, peripheral oxygen saturation, and systolic and diastolic blood pressure were recorded intraoperatively and for 48 hr postoperatively. Patients used a patient-controlled analgesia device to receive bolus doses of morphine after surgery. Total morphine consumption, pain scores, and sedation scores were recorded for the first 48 hr (two hours in the postanesthesia care unit and 46 hr on the ward). Results: The groups were similar with respect to mean times to extubation of the trachea. Pain and sedation scores were also similar between groups at all corresponding times throughout the 48-hr period of observation. Group D patients consumed significantly less morphine in the postanesthesia care unit and on the ward (P < 0.05 and P < 0.01, respectively). Fewer patients in Group D experienced itching or nausea/vomiting (P < 0.05). Conclusion: Continuous iv dexmedetomidine during abdominal surgery provides effective postoperative analgesia, and reduces postoperative morphine requirements without increasing the incidence of side effects.en_US
dc.identifier.citationGürbet, A. vd. (2006). ''Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements''. Canadian Journal of Anaesthesia-Journal Canadien D. Anesthesie, 53(7), 646-652.en_US
dc.identifier.endpage652tr_TR
dc.identifier.issn0832-610X
dc.identifier.issue7tr_TR
dc.identifier.pubmed16803911tr_TR
dc.identifier.scopus2-s2.0-33747602977tr_TR
dc.identifier.startpage646tr_TR
dc.identifier.urihttps://doi.org/10.1007/BF03021622
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007%2FBF03021622.pdf
dc.identifier.urihttp://hdl.handle.net/11452/21426
dc.identifier.volume53tr_TR
dc.identifier.wos000238727800003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherCanadian Anesthesiologists Socen_US
dc.relation.journalCanadian Journal of Anaesthesia-Journal Canadien D. Anesthesieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnesthesiologyen_US
dc.subjectSedationen_US
dc.subjectRemifentanilen_US
dc.subjectPainen_US
dc.subjectHumansen_US
dc.subjectMorphineen_US
dc.subjectClonidineen_US
dc.subjectIncreasing plasma-concentrationsen_US
dc.subjectPostoperative analgesiaen_US
dc.subjectRegional anesthesiaen_US
dc.subjectHealthy-volunteersen_US
dc.subject.scopusDexmedetomidine; Sedation; Adrenergic Receptor Blocking Agenten_US
dc.subject.wosAnesthesiologyen_US
dc.titleIntraoperative infusion of dexmedetomidine reduces perioperative analgesic requirementsen_US
dc.typeArticle

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