Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer

Simple item page
dc.contributor.buuauthorSevinç, Elif Demirdöğen
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorAk, Seçil
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorGökgöz, Şehsuvar
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.buuauthorTaşdelen, İsmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.scopusid56508326500tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid55253485700tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6603238737tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid9637821500tr_TR
dc.date.accessioned2022-11-28T08:10:48Z
dc.date.available2022-11-28T08:10:48Z
dc.date.issued2016-09-30
dc.description.abstractThe dysregulation of miRNA expression has frequently been observed in breast cancer. Therefore, we investigated the expression profile of miRNAs that may be associated with expression of the FHIT gene in breast cancer and assessed their clinicopathological significance. The expression levels of miR-143, miR-663a, miR-668, miR-922 and FHIT were analyzed in normal and malignant breast tissues from 65 patients with breast cancer. We studied the correlation between the expression of miR-143, miR-663a, miR-668, miR-922 and FHIT and the clinicopathological features presented by the patients. The expression levels of the miRNAs and FHIT were downregulated in breast cancer tissue. The expression levels of miR-143, miR-663a and miR-668 were significantly reduced in FHIT downregulated tumors. miR-668 expression was also significantly altered relative to FHIT down- and up- regulated tumor tissues. Reduced miR-663a expression was statistically associated with high-grade ER/PR (+) status, benign reactive hyperplasia, lymph-node metastasis, in-situ component >25% and Ki 67 > 15% compared with non-tumor tissues. Additionally, reduced miR-668 expression was significantly different between tumors with and without lymph-node metastasis. miR-668 may play an important role in breast cancer development and progression by regulating the expression of FHIT. Furthermore, miR-668 and miR-663a may be potential prognostic biomarkers for breast cancer.en_US
dc.identifier.citationSevinç, E. D. vd. (2016). "Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer". Gene, 590(2), 278-284.en_US
dc.identifier.endpage284tr_TR
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.issue2tr_TR
dc.identifier.pubmed27236032tr_TR
dc.identifier.scopus2-s2.0-84976465950tr_TR
dc.identifier.startpage278tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.gene.2016.05.033
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378111916304103
dc.identifier.urihttp://hdl.handle.net/11452/29587
dc.identifier.volume590tr_TR
dc.identifier.wos000381842700011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapUAP(T)-2011/7tr_TR
dc.relation.journalGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenetics & heredityen_US
dc.subjectBreast canceren_US
dc.subjectFHITen_US
dc.subjectmiR-143en_US
dc.subjectmiR-663aen_US
dc.subjectmiR-668en_US
dc.subjectmiR-922en_US
dc.subjectCell-proliferationen_US
dc.subjectMicrornasen_US
dc.subjectClassificationen_US
dc.subjectBiomarkersen_US
dc.subjectPhenotypeen_US
dc.subjectRnasen_US
dc.subject.emtreeEstrogen receptoren_US
dc.subject.emtreeFragile histidine triad proteinen_US
dc.subject.emtreeKi 67 antigenen_US
dc.subject.emtreeMicroRNAen_US
dc.subject.emtreeMicroRNA 143en_US
dc.subject.emtreeMicroRNA 663aen_US
dc.subject.emtreeMicroRNA 668en_US
dc.subject.emtreeMicroRNA 922en_US
dc.subject.emtreeProgesterone receptoren_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAcid anhydride hydrolaseen_US
dc.subject.emtreeFragile histidine triad proteinen_US
dc.subject.emtreeMicroRNAen_US
dc.subject.emtreeTumor proteinen_US
dc.subject.emtree3' untranslated regionen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer prognosisen_US
dc.subject.emtreeCancer tissueen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeGene expression profilingen_US
dc.subject.emtreeGene expression regulationen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeHyperplasiaen_US
dc.subject.emtreeLymph node metastasisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeTumor geneen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeBiologyen_US
dc.subject.emtreeBreast tumoren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAcid anhydride hydrolasesen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshComputational biologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene expression profilingen_US
dc.subject.meshGene expression regulation, neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroRNAsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeoplasm proteinsen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusNucleotide Binding Protein; Histidine; Triaden_US
dc.subject.wosGenetics & heredityen_US
dc.titleExpression and clinical significance of miRNAs that may be associated with the FHIT gene in breast canceren_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus