The expression frequency of common fragile sites and genetic predisposition to colon cancer

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dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorZorluoğlu, Abdullah
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorKızıl, Ayhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.date.accessioned2021-09-08T06:54:38Z
dc.date.available2021-09-08T06:54:38Z
dc.date.issued2000
dc.description.abstractThe expression frequency of common fragile sites induced by aphidicolin (Apc), bromodeoxyuridine (BrdU), and caffeine was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 32 patients with colon cancer, 30 of their clinically healthy family members and 30 age-matched normal controls. The proportion of-damaged cells (P < 0.001), the mean number of chromosomal aberrations and the expression frequencies of fragile sites were significantly higher in the patient and relative groups compared to the control group. Our findings show an increased genetic instability in patients with colon cancer and their first-degree relatives. In addition, common fragile sites can be used as a suitable marker for determining genetic predisposition to cancer.en_US
dc.identifier.citationTunca, B. vd. (2000). "The expression frequency of common fragile sites and genetic predisposition to colon cancer". Cancer Genetics and Cytogenetics, 119(2), 139-145.en_US
dc.identifier.endpage145tr_TR
dc.identifier.issn0165-4608
dc.identifier.issue2tr_TR
dc.identifier.pubmed10867150tr_TR
dc.identifier.scopus2-s2.0-0034043323tr_TR
dc.identifier.startpage139tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0165-4608(99)00228-9
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165460899002289
dc.identifier.urihttp://hdl.handle.net/11452/21759
dc.identifier.volume119tr_TR
dc.identifier.wos000087783800010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalCancer Genetics and Cytogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectCell lung-canceren_US
dc.subjectShort armen_US
dc.subjectBreast-canceren_US
dc.subjectChromosome breakpointsen_US
dc.subjectColorectal-canceren_US
dc.subjectFhit geneen_US
dc.subjectHeterozygosityen_US
dc.subjectLymphocytesen_US
dc.subjectAphidicolinen_US
dc.subjectAssociationen_US
dc.subject.scopusWW Domain Containing Oxidoreductase; Spinocerebellar Ataxia 12; Chromosome Fragile Sitesen_US
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.titleThe expression frequency of common fragile sites and genetic predisposition to colon canceren_US
dc.typeArticle
dc.wos.quartileQ3en_US

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