Effects of adrenomedullin and glucagon-like peptide on distal flap necrosis and vascularity: The role of receptor systems and nitric oxide

Basit Görünüm
dc.contributor.buuauthorCam, Betül
dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorÖzyiğit, Musa Özgür
dc.contributor.buuauthorSağdilek, Engin
dc.contributor.buuauthorBüyükcoşkun, Naciye İsbil
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyofizik Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.researcheridAAH-2873-2021tr_TR
dc.contributor.researcheridAAR-6478-2021tr_TR
dc.contributor.researcheridAAH-4397-2021tr_TR
dc.contributor.scopusid56427863700tr_TR
dc.contributor.scopusid15062425700tr_TR
dc.contributor.scopusid6507338060tr_TR
dc.contributor.scopusid16835756600tr_TR
dc.contributor.scopusid6603128152tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.date.accessioned2023-02-09T06:11:19Z
dc.date.available2023-02-09T06:11:19Z
dc.date.issued2017-06
dc.description.abstractObjective. Flap necrosis in the distal area due to the deficiency of blood circulation is a major complication in flap treatment. In many previous studies, some natural substances such as chlorogenic acid, adrenomedullin (ADM), and glucagon-like peptide-1 (GLP-1) have been used to improve flap viability via their vasodilator, angiogenic, and antioxidant effects. The aim of this study is to clarify the mechanism through the use of selective antagonists for calcitonin gene-related peptide (CGRP) receptors and GLP-1,receptors such as CGRP-(8-37), exendin-(9-39), respectively, in the flap healing effects of ADM and GLP-1. The role of nitric oxide (NO) was investigated in the mechanism as well. Materials and Methods. Seventy adult female Wistar rats (200 g-250 g) were used in the study. The cutaneous skin flap (8 cm x 3 cm) on the abdominal wall was raised based on the superficial inferior epigastric artery (SIEA). Single-dose substance injections were administered into the SIEA. Necrosis in the flap area was evaluated on postoperative day 7. The proportion of the necrosis area (necrosis area % = [necrosis area/ flap area] x 100) and vascularity (vascular number/cm(2)) in the distal area were calculated. Results. The administrations of ADM or GLP-1 increased the vascularity and decreased the necrosis area in the distal flap region. The ADM receptor antagonist, CGRP-(8-37), did not prevent the positive effects of ADM on flap healing and vascularity. A GLP-1 receptor antagonist, exendin-(9-39), prevented the effect of GLP-1 on flap healing and vascularity. Nitric oxide mediated the beneficial effects of both peptides on flap healing. Conclusion. The CGRP receptors have no direct role, but NO acts as a mediator in the beneficial effect of ADM on flap healing. The GLP-1 specific receptors and NO act as important interagents for the effects of GLP-1 on flap healing.en_US
dc.identifier.citationCam, B. vd. (2017). ''Effects of adrenomedullin and glucagon-like peptide on distal flap necrosis and vascularity: The role of receptor systems and nitric oxide''. Wounds, 29(6), 163-167.en_US
dc.identifier.endpage167tr_TR
dc.identifier.issn1044-7946
dc.identifier.issue6tr_TR
dc.identifier.pubmed28355142tr_TR
dc.identifier.scopus2-s2.0-85049241898tr_TR
dc.identifier.startpage163tr_TR
dc.identifier.uri1943-2704
dc.identifier.urihttp://hdl.handle.net/11452/30918
dc.identifier.volume29tr_TR
dc.identifier.wos000405060000003tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherH. M. P. Commjnicationsen_US
dc.relation.journalWoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectSurgeryen_US
dc.subjectFlap necrosisen_US
dc.subjectAdrenomedullinen_US
dc.subjectGlucagon-like peptide-1en_US
dc.subjectAngiogenesisen_US
dc.subjectEndothelial growth-factoren_US
dc.subjectA signaling pathwayen_US
dc.subjectCell-proliferationen_US
dc.subjectProtein-kinaseen_US
dc.subjectSkin flapsen_US
dc.subjectBeta-cellsen_US
dc.subjectRat modelen_US
dc.subjectAngiogenesisen_US
dc.subjectApoptosisen_US
dc.subjectSurvivalen_US
dc.subject.emtreeAdrenomedullinen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeCalcitonin gene related peptideen_US
dc.subject.emtreeCalcitonin gene related peptide receptoren_US
dc.subject.emtreeGlucagon like peptideen_US
dc.subject.emtreeGlucagon like peptide receptoren_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDisease modelen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEpigastric arteryen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGraft survivalen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeInjuryen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNecrosisen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSurgical flapsen_US
dc.subject.emtreeVascularizationen_US
dc.subject.emtreeWistar raten_US
dc.subject.emtreeWound healingen_US
dc.subject.meshAdrenomedullinen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshCalcitonin gene-related peptideen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshEpigastric arteriesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucagon-like peptide receptorsen_US
dc.subject.meshGlucagon-like peptidesen_US
dc.subject.meshGraft survivalen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNecrosisen_US
dc.subject.meshNitric oxideen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReceptors, calcitonin gene-related peptideen_US
dc.subject.meshSurgical flapsen_US
dc.subject.meshWound healingen_US
dc.subject.meshWounds and injuriesen_US
dc.subject.scopusFlaps (Control Surfaces); Perforator Flap; Reperfusion Injuryen_US
dc.subject.wosDermatologyen_US
dc.subject.wosSurgeryen_US
dc.titleEffects of adrenomedullin and glucagon-like peptide on distal flap necrosis and vascularity: The role of receptor systems and nitric oxideen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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