Structural and neurochemical evaluation of the brain and pons in patients with Wilson's disease

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dc.contributor.authorAlgın, Oktay
dc.contributor.buuauthorTaşkapılıoğlu, Özlem
dc.contributor.buuauthorHakyemez, Bahattin
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorYurtoğulları, Şükran
dc.contributor.buuauthorErer Özbek, Sevda
dc.contributor.buuauthorParlak, Müfit
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3425-0740tr_TR
dc.contributor.researcheridAAI-2318-2021tr_TR
dc.contributor.researcheridAAG-8521-2021tr_TR
dc.contributor.researcheridAAK-6623-2020tr_TR
dc.contributor.researcheridAAH-5180-2021tr_TR
dc.contributor.scopusid23037226400tr_TR
dc.contributor.scopusid6602527239tr_TR
dc.contributor.scopusid15832295800tr_TR
dc.contributor.scopusid36873746200tr_TR
dc.contributor.scopusid25635370800tr_TR
dc.contributor.scopusid7003589220tr_TR
dc.date.accessioned2022-03-14T13:24:35Z
dc.date.available2022-03-14T13:24:35Z
dc.date.issued2010-11
dc.description.abstractThe aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson's disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI). Nine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated. DWI scans from six WD patients and six controls were also obtained. The relative metabolite ratios and apparent diffusion coefficient (ADC) values of the WD patients were compared to those of the control subjects by using statistical measures. Measurements in the thalamus and pons showed significantly lower NAA/Cho and NAA/Cr ratios in the WD group than in the control group (P < 0.05). Thalamic and pontine Cho/Cr ratios in the patient group were significantly higher than those of the control group (P < 0.05). No statistically significant relation was found between the patient and control groups as a result of the MRS examinations of FWM and all ADC measurements (P > 0.05). MRS is a noninvasive, valuable modality for detecting structural-neurochemical changes of the brain stem and deep gray matter in patients with WD. The contribution of DWI in these patients is limited.en_US
dc.identifier.citationAlgın, O. vd. (2010). "Structural and neurochemical evaluation of the brain and pons in patients with Wilson's disease". Japanese Journal of Radiology, 28(9), 663-671.en_US
dc.identifier.endpage671tr_TR
dc.identifier.issn1867-1071
dc.identifier.issn1867-108X
dc.identifier.issue9tr_TR
dc.identifier.pubmed21113750tr_TR
dc.identifier.scopus2-s2.0-79953322680tr_TR
dc.identifier.startpage663tr_TR
dc.identifier.urihttps://doi.org/10.1007/s11604-010-0491-4
dc.identifier.urihttps://link.springer.com/article/10.1007/s11604-010-0491-4
dc.identifier.urihttp://hdl.handle.net/11452/25009
dc.identifier.volume28tr_TR
dc.identifier.wos000284645900005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalJapanese Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWilson's diseaseen_US
dc.subjectProton MR spectroscopyen_US
dc.subjectNeuroimagingen_US
dc.subjectDiffusion magnetic resonance imagingen_US
dc.subjectNeuronal lossen_US
dc.subjectKayser-Fleischer ringsen_US
dc.subjectClinical correlationen_US
dc.subjectDiffusionen_US
dc.subjectRadiology, nuclear medicine & medical imagingen_US
dc.subject.emtreeAspartic aciden_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCreatineen_US
dc.subject.emtreeDrug derivativeen_US
dc.subject.emtreeN acetylaspartic aciden_US
dc.subject.emtreeN-acetylaspartateen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrainen_US
dc.subject.emtreeDiffusion weighted imagingen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeNeurochemistryen_US
dc.subject.emtreeNuclear magnetic resonance spectroscopyen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePonsen_US
dc.subject.emtreeScintiscanningen_US
dc.subject.emtreeWilson diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAspartic aciden_US
dc.subject.meshBrainen_US
dc.subject.meshCholineen_US
dc.subject.meshCreatinen_US
dc.subject.meshDiffusion magnetic resonance imagingen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatolenticular degenerationen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic resonance spectroscopyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeurochemistryen_US
dc.subject.meshPonsen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusHepatolenticular Degeneration; Copper-transporting ATPases; Penicillamineen_US
dc.subject.wosRadiology, nuclear medicine & medical imagingen_US
dc.titleStructural and neurochemical evaluation of the brain and pons in patients with Wilson's diseaseen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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