The mediation of the central histaminergic system in the pressor effect of intracerebroventricularly injected melittin, a phospholipase A(2) activator, in normotensive rats

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dc.contributor.authorJochem, Jerzy
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorTopuz, Bora B.
dc.contributor.buuauthorYılmaz, Mustafa S.
dc.contributor.buuauthorAydın, Cenk
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorAydın, Sami
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.orcid0000-0002-3090-0099tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.scopusid55356919300tr_TR
dc.contributor.scopusid55357889700tr_TR
dc.contributor.scopusid8895544100tr_TR
dc.contributor.scopusid7005426982tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.contributor.scopusid7005387015tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-06-14T11:05:58Z
dc.date.available2022-06-14T11:05:58Z
dc.date.issued2012
dc.description.abstractMelittin is a polypeptide component of bee venom that leads to an increase in arachidonic acid release and subsequently in prostaglandin synthesis by activating phospholipase A(2). Recently we demonstrated that centrally or peripherally administrated melittin caused pressor effect and central thromboxane A(2) (TXA(2)) and cholinergic system mediated these effects of melittin. Also centrally injected histamine leads to pressor and bradycardic response by activating central histamine receptors in normotensive rats and central cholinergic system involved the effects of histamine. The present study demonstrates an involvement of the central histaminergic system in melittin-induced cardiovascular effect in normotensive rats. Experiments were carried out in male Sprague Dawley rats. Intracerebroventricularly (i.c.v.) injected melittin (0.5, 1 and 2 nmol) caused dose- and time-dependent increases in mean arterial pressure (MAP) and decrease in heart rate (HR) as we reported previously. Moreover, H-2 receptor antagonist ranitidine (50 nmol; icy.) almost completely and H-3/H-4 receptor antagonist thioperamide (50 nmol; i.c.v.) partly blocked melittin-evoked cardiovascular effects, whereas H-1 receptor blocker chlorpheniramine (50 nmol; icy.) had no effect. Also centrally injected melittin was accompanied by 28% increase in extracellular histamine concentration in the posterior hypothalamus, as shown in microdialysis studies. In conclusion, results show that centrally administered melittin causes pressor and bradycardic response in conscious rats. Moreover, according to our findings, there is an involvement of the central histaminergic system in melittin-induced cardiovascular effects.en_US
dc.identifier.citationAltınbaş, B. vd. (2012). "The mediation of the central histaminergic system in the pressor effect of intracerebroventricularly injected melittin, a phospholipase A(2) activator, in normotensive rats". Prostaglandins Leukotrienes and Essential Fatty Acids, 87(4-5), 153-158.en_US
dc.identifier.endpage158tr_TR
dc.identifier.issn0952-3278
dc.identifier.issn1532-2823
dc.identifier.issue4-5tr_TR
dc.identifier.pubmed22995146tr_TR
dc.identifier.scopus2-s2.0-84867233565tr_TR
dc.identifier.startpage153tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2012.08.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0952327812001482
dc.identifier.urihttp://hdl.handle.net/11452/27150
dc.identifier.volume87tr_TR
dc.identifier.wos000311024000008tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalProstaglandins Leukotrienes and Essential Fatty Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak110O878tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectBrain phospholipase a(2)en_US
dc.subjectMelittinen_US
dc.subjectMean arterial pressureen_US
dc.subjectHeart rateen_US
dc.subjectCentral histaminergic systemen_US
dc.subjectMicrodialysisen_US
dc.subjectIntracerebroventricularen_US
dc.subjectCritical hemorrhagic hypotensionen_US
dc.subjectCentral cardiovascular regulationen_US
dc.subjectCentral cholinergic systemen_US
dc.subjectThromboxane a2 analogen_US
dc.subjectInduced reversalen_US
dc.subjectAdministered histamineen_US
dc.subjectArachidonic-aciden_US
dc.subjectInvolvementen_US
dc.subjectShocken_US
dc.subjectU-46619en_US
dc.subjectApoideaen_US
dc.subjectRattusen_US
dc.subject.emtreeChlorpheniramineen_US
dc.subject.emtreeHistamineen_US
dc.subject.emtreeMelittinen_US
dc.subject.emtreeRanitidineen_US
dc.subject.emtreeThioperamideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood pressure monitoringen_US
dc.subject.emtreeBrain levelen_US
dc.subject.emtreeCentral nervous systemen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeEvoked responseen_US
dc.subject.emtreeHeart rate variabilityen_US
dc.subject.emtreeHistamine releaseen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeMicrodialysisen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePosterior hypothalamusen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.meshAnimalsen_US
dc.subject.meshArterial pressureen_US
dc.subject.meshInjectionsen_US
dc.subject.meshIntraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMelittenen_US
dc.subject.meshMicrodialysisen_US
dc.subject.meshPhospholipases a2en_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleThe mediation of the central histaminergic system in the pressor effect of intracerebroventricularly injected melittin, a phospholipase A(2) activator, in normotensive ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US
dc.wos.quartileQ2 (Endocrinology & metabolism)en_US

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