The effects of different hormone replacement treatment regimens on tear function, intraocular pressure and lens opacity
dc.contributor.buuauthor | Uncu, Gürkan | |
dc.contributor.buuauthor | Avcı, Remzi | |
dc.contributor.buuauthor | Kaymaz, Cafer | |
dc.contributor.buuauthor | Uncu, Yeşim | |
dc.contributor.buuauthor | Develioğlu, Osman Haldun | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-5225-4403 | tr_TR |
dc.contributor.researcherid | D-9597-2016 | tr_TR |
dc.contributor.scopusid | 6603716169 | tr_TR |
dc.contributor.scopusid | 7004838001 | tr_TR |
dc.contributor.scopusid | 8892370600 | tr_TR |
dc.contributor.scopusid | 6603750027 | tr_TR |
dc.contributor.scopusid | 6701315440 | tr_TR |
dc.date.accessioned | 2022-03-23T11:00:15Z | |
dc.date.available | 2022-03-23T11:00:15Z | |
dc.date.issued | 2002-09 | |
dc.description | Bu çalışma, 12-17 Ocak 2002 tarihleri arasında Seattle[ABD]'da düzenlenen 58. Annual Meeting of the American Society for Reproductive Medicine'de bildiri olarak sunulmuştur. | tr_TR |
dc.description.abstract | Objective. Estrogen may have adverse effects on the ocular surface, intraocular pressure (IOP), lens opacity and tear function. The aim of the present study was to elucidate the effects of different hormone replacement therapy (HRT) protocols on tear function, IOP and lens opacity. Design and setting. This was a prospective, uncontrolled study carried out at the Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Uludaǧ University, Turkey. Patients and interventions. Thirty postmenopausal patients who had spontaneous or surgical menopause for at least 1 year and were not taking any medications were assigned to one of three groups. Group 1 comprised 19 patients (n = 38 observations) given conjugated equine estrogen 0.625 mg plus medroxyprogesterone acetate 2.5 mg (Premelle 2.5®) daily; Group 2 contained six patients (n = 12 observations) given tibolone 2.5 mg (Livial®) daily; and Group 3 comprised five patients (n = 10 observations) treated with estradiol patch, 3.9 mg/12 cm2 (Climara®). Tear function, evaluated with Schirmer's test, IOP and lens opacity were determined before treatment and at 6 and 12 months of treatment. Results. Mean Schirmer's test score in each group and all eyes (n = 60) did not change significantly after 6 months of treatment but decreased significantly at 12 months. The percentage decrease in tear function was greatest in the estrogen-only group (Group 3). Mean IOP did not change significantly in Groups 1 and 2; however, in Group 3, IOP showed a statistically significant decrease from 14.63 ± 0.84 mmHg before treatment to 12.60 ± 0.68 mmHg (mean ± standard error) at the end of treatment. Lens opacity in women of all groups did not change during treatment. Conclusions. HRT decreased tear production, the decrease being greater in the estrogen- only group. Woman who are taking or considering HRT should be informed of the potential increased risk of dry eye syndrome with this therapy. In addition, estrogen-only treatment decreased IOP while estrogen plus progesterone and tibolone had no effect. HRT did not affect lens opacity after 12 months of treatment. | en_US |
dc.description.sponsorship | American Society of Reproductive Medicine | en_US |
dc.identifier.citation | Uncu, G. vd. (2002). "The effects of different hormone replacement treatment regimens on tear function, intraocular pressure and lens opacity." Fertility and Sterility, 78(3), 98-99. | en_US |
dc.identifier.endpage | 99 | tr_TR |
dc.identifier.issn | 0015-0282 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.scopus | 2-s2.0-33750473043 | tr_TR |
dc.identifier.startpage | 98 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/S0015-0282(02)03641-5 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0015028202036415 | |
dc.identifier.uri | http://hdl.handle.net/11452/25302 | |
dc.identifier.volume | 78 | tr_TR |
dc.identifier.wos | 000178239400261 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.wos | CPCIS | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science | en_US |
dc.relation.journal | Fertility and Sterility | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Obstetrics & gynecology | en_US |
dc.subject | Reproductive biology | en_US |
dc.subject | Dry eye syndrome | en_US |
dc.subject | Hormone replacement therapy | en_US |
dc.subject | Intraocular pressure | en_US |
dc.subject | Lens opacity | en_US |
dc.subject | Schirmer's test | en_US |
dc.subject | Livial | en_US |
dc.subject | Premelle | en_US |
dc.subject | Climara | en_US |
dc.subject.emtree | Cataract | en_US |
dc.subject.emtree | Conjugated estrogen plus medroxyprogesterone acetate | en_US |
dc.subject.emtree | Estradiol | en_US |
dc.subject.emtree | Tibolone | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Dry eye | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Hormone substitution | en_US |
dc.subject.emtree | Hospital department | en_US |
dc.subject.emtree | Intraocular hypotension | en_US |
dc.subject.emtree | Menopausal syndrome | en_US |
dc.subject.emtree | Intraocular hypertension | en_US |
dc.subject.emtree | Intraocular pressure | en_US |
dc.subject.emtree | Lacrimation | en_US |
dc.subject.emtree | Postmenopause | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Schirmer test | en_US |
dc.subject.emtree | Turkey (republic) | en_US |
dc.subject.mesh | Menopause | en_US |
dc.subject.mesh | Cataract | en_US |
dc.subject.mesh | Estrogens | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hormone replacement therapy | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intraocular pressure | en_US |
dc.subject.mesh | Medroxyprogesterone 17-acetate | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Norpregnenes | en_US |
dc.subject.mesh | Tears | en_US |
dc.subject.scopus | Meibomian Glands; Intraocular Pressure; Open Angle Glaucoma | en_US |
dc.subject.wos | Obstetrics & gynecology | en_US |
dc.subject.wos | Reproductive biology | en_US |
dc.title | The effects of different hormone replacement treatment regimens on tear function, intraocular pressure and lens opacity | en_US |
dc.type | Meeting Abstract | |
dc.wos.quartile | Q1 | en_US |
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