Adiponectin and its protective effects

dc.contributor.buuauthorGuzel, Saime
dc.contributor.buuauthorYalcin, Abdullah
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.date.accessioned2021-03-16T06:17:13Z
dc.date.available2021-03-16T06:17:13Z
dc.date.issued2012
dc.description.abstractAdiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is one of the adipocytokines that is secreted by the white adipose tissue and is an important regulator of lipid and glucose metabolism. It is an insulin-sensitizing hormone with anti-diabetic, anti-inflammatory, anti-atherogenic and anti-proliferative properties. It was demonstrated that decreased serum adiponectin levels are associated with insulin resistance and type 2 diabetes. Furthermore, hypoadiponectinemia was shown to be associated with coronary artery disease. Several authors point out that high levels of circulating adiponectin reduce risk of coronary heart disease among type 2 diabetes patients. Adiponectin has also been shown to play an important role in the regulation of cell proliferation and tumorigenesis. Adiponectin, via its cognate receptors AdipoR1 and AdipoR2, inhibits cancer cell proliferation in vitro and supressess obesity-associated tumor growth in vivo (e.g. colorectal, gastric, liver, and breast cancer). Therefore, potential diagnostic and therapeutic usage of adiponectin has been subject of an increasing interest in recent years.en_US
dc.identifier.citationGuzel, S. ve Yalcin, A. (2012). "Adiponectin and its protective effects". Journal of Biological and Environmental Sciences, 6(17), 135-139.tr_TR
dc.identifier.endpage139tr_TR
dc.identifier.issn1307-9530
dc.identifier.issn1308-2019
dc.identifier.issue17tr_TR
dc.identifier.startpage135tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/497513
dc.identifier.urihttp://hdl.handle.net/11452/17733
dc.identifier.volume6tr_TR
dc.language.isoenen_US
dc.publisherUludağ Üniversitesitr_TR
dc.relation.journalJournal of Biological and Environmental Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdiponectinen_US
dc.subjectAtherogenesisen_US
dc.subjectCanceren_US
dc.subjectInflammationen_US
dc.subjectAMPKen_US
dc.subjectObesityen_US
dc.titleAdiponectin and its protective effectsen_US
dc.typeArticleen_US

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