Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study

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dc.contributor.authorCeruotti, Ferruccio
dc.contributor.authorHenny, Joseph
dc.contributor.authorQueralto, Josep
dc.contributor.authorZiyu, Shen
dc.contributor.authorChen, Baorong
dc.contributor.authorBoyd, James C.
dc.contributor.authorPanteghini, Mauro
dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya ve Klinik Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.date.accessioned2021-10-26T20:33:22Z
dc.date.available2021-10-26T20:33:22Z
dc.date.issued2010-11
dc.description.abstractBackground: Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim of this study was to define the reference intervals (RIs) for these enzymes in adults, paying attention to standardization of the methods used and careful selection of the reference population. Methods: AST, ALT and GGT were measured with commercial analytical systems standardized to the IFCC-recommended reference measurement systems. Three centers (two in Italy and one in China) measured their own freshly collected samples; one of these centers also measured frozen samples from the Nordic Countries RI Project and from a Turkish center. RIs were generated using non-parametric techniques from the results of 765 individuals (411 females and 354 males, 18-85 years old) selected on the basis of the results of other laboratory tests and a specific questionnaire. Results: AST results from the four regions (Milan, Beijing, Bursa and Nordic Countries) were statistically different, but these differences were too small to be clinically relevant. Likewise, differences between the upper reference limits for genders was only 1.7 U/L (0.03 mu kat/L), allowing a single RI of 11-34 U/L (0.18-0.57 mu kat/L) to be defined. Inter-regional differences were not statistically significant for ALT, but partitioning was required due to significant gender differences. RIs for ALT were 8-41 U/L (0.13-0.68 mu kat/L) for females and 9-59 U/L (0.15-0.99 mu kat/L) for males, respectively. The upper reference limits for GGT from the Nordic Country population were higher than those from the other three regions and results from this group were excluded from final calculations. The GGT RIs were 6-40 U/L (0.11-0.66 mu kat/L) for females and 12-68 U/L (0.20-1.13 mu kat/L) for males, respectively. Conclusions: For AST and ALT, the implementation of common RIs appears to be possible, because no differences between regions were observed. However, a common RI for GGT that is applicable worldwide appears unlikely due to differences among populations. Clin Chem Lab Med 2010;48:1593-601.en_US
dc.description.sponsorshipIFCCen_US
dc.description.sponsorshipAbbott Laboratoriesen_US
dc.description.sponsorshipOrtho-Clinical Diagnostics Inc.en_US
dc.description.sponsorshipSysmex Europe GmbHen_US
dc.description.sponsorshipBinding Site Ltd.en_US
dc.identifier.citationCeruotti, F. vd. (2010). "Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study". Clinical Chemistry and Laboratory Medicine, 48(11), 1593-1601.en_US
dc.identifier.endpage1601tr_TR
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue11tr_TR
dc.identifier.pubmed21034260tr_TR
dc.identifier.scopus2-s2.0-78751615234tr_TR
dc.identifier.startpage1593tr_TR
dc.identifier.urihttps://doi.org/10.1515/CCLM.2010.315
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/CCLM.2010.315/html
dc.identifier.urihttp://hdl.handle.net/11452/22484
dc.identifier.volume48tr_TR
dc.identifier.wos000284101000008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWalter de Gruyteren_US
dc.relation.bapUAP(T)-2009/10tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlanine aminotransferaseen_US
dc.subjectAspartate aminotransferaseen_US
dc.subjectGamma-glutamyl transferaseen_US
dc.subjectReference intervalsen_US
dc.subjectCatalytic-activity concentrationsen_US
dc.subject6 Asian citiesen_US
dc.subjectInternational-federationen_US
dc.subjectReference limitsen_US
dc.subjectHealthy-subjectsen_US
dc.subjectReference valuesen_US
dc.subjectEnzymesen_US
dc.subject37-degrees-cen_US
dc.subjectParten_US
dc.subjectStandardizationen_US
dc.subjectMedical laboratory technologyen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeGamma glutamyltransferaseen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspartate aminotransferase blood levelen_US
dc.subject.emtreeChinaen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeCreatine kinase blood levelen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGamma glutamyl transferase blood levelen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeItalyen_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQuestionnaireen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeSex differenceen_US
dc.subject.emtreeStandardizationen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUric acid blood levelen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAlanine transaminaseen_US
dc.subject.meshAspartate aminotransferasesen_US
dc.subject.meshBlood chemical analysisen_US
dc.subject.meshEthnic groupsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGamma-glutamyltransferaseen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational agenciesen_US
dc.subject.meshLaboratoriesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshReference valuesen_US
dc.subject.meshReproducibility of resultsen_US
dc.subject.meshSex factorsen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusClinical Chemistry; Thyrotropin; Nonparametric Methodsen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleCommon reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) in serum: results from an IFCC multicenter studyen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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