Maternal preeclampsia is associated with increased risk of necrotizing enterocolitis in preterm infants

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dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bölümü.tr_TR
dc.contributor.researcheridAAG-8393-2021tr_TR
dc.contributor.scopusid23994946300tr_TR
dc.contributor.scopusid16679325400tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.date.accessioned2021-11-19T12:02:19Z
dc.date.available2021-11-19T12:02:19Z
dc.date.issued2012-11
dc.description.abstractBackground: Necrotizing enterocolitis (NEC) is an important cause of mortality and morbidity in preterm infants. Aims: To evaluate the effect of maternal preeclampsia on the development and severity of NEC in premature infants. Study design: Prospective observational study in a tertiary neonatal intensive care unit. Subjects: The preterm infants of <= 37 gestational age who were consecutively hospitalized were enrolled. The study group contained preterm infants born to a preeclamptic mother and the comparison group contained preterm infants born to a normotensive mother. Outcome measures: The primary outcome was to determine the association between preeclampsia and NEC. Results: A total of 88 infants had NEC diagnosis. The incidence of NEC in infants born to preeclamptic mothers (22.9%) was significantly higher compared with those born to normotensive mothers (14.6%). According to NEC stages, NEC was more advanced in preeclamptic mother infants. NEC developed significantly earlier in infants with NEC in the study group. The duration of NEC was also significantly longer in infants born to preeclamptic mothers. In multiple logistic regression model, preeclampsia was found to be predictive of NEC with an odds ratio of 1.74 (95% confidence interval 0.64-0.92). Conclusions: Maternal preeclampsia may be an important risk factor for the development of NEC in premature infants as NEC incidence and severity of NEC were found to be significantly higher in premature infants born to preeclamptic mothers. The onset of NEC was significantly earlier and duration of NEC was longer in these infants.en_US
dc.identifier.citationÇetinkaya, M. vd. (2012). "Maternal preeclampsia is associated with increased risk of necrotizing enterocolitis in preterm infants". Early Human Development, 88(11), 893-898.en_US
dc.identifier.endpage898tr_TR
dc.identifier.issn0378-3782
dc.identifier.issn1872-6232
dc.identifier.issue11tr_TR
dc.identifier.pubmed22831636tr_TR
dc.identifier.scopus2-s2.0-84866878194tr_TR
dc.identifier.startpage893tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.earlhumdev.2012.07.004
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22831636/
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378378212001661
dc.identifier.urihttp://hdl.handle.net/11452/22737
dc.identifier.volume88tr_TR
dc.identifier.wos000309800800008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.relation.journalEarly Human Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectPediatricsen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectPreeclampsiaen_US
dc.subjectPreterm infanten_US
dc.subjectRisk factoren_US
dc.subjectGastrointestinal blood-flowen_US
dc.subjectNeonatal outcomesen_US
dc.subjectOxygen-consumptionen_US
dc.subjectPathogenesisen_US
dc.subjectPreventionen_US
dc.subjectDeliveryen_US
dc.subjectAbsenten_US
dc.subjectBornen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGestational ageen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMotheren_US
dc.subject.emtreeNecrotizing enterocolitisen_US
dc.subject.emtreeObservational studyen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreePredictive valueen_US
dc.subject.emtreePreeclampsiaen_US
dc.subject.emtreePrematurityen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshEnterocolitis, necrotizingen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshInfant, prematureen_US
dc.subject.meshInfant, premature, diseasesen_US
dc.subject.meshMaleen_US
dc.subject.meshPre-eclampsiaen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRisk factorsen_US
dc.subject.scopusNecrotizing Enterocolitis; Prematurity; Intestine Perforationen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.subject.wosPediatricsen_US
dc.titleMaternal preeclampsia is associated with increased risk of necrotizing enterocolitis in preterm infantsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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