Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26

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dc.contributor.authorKotenko, Sergei V.
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorMani, Orlando
dc.contributor.authorZumkehr, Judith
dc.contributor.authorBlaser, Kurt
dc.contributor.authorAkdiş, Cezmi A.
dc.contributor.authorAkdiş, Mübeccel
dc.contributor.buuauthorOral, Haluk B
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı/İmmünoloji Bölümü.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2021-08-18T08:15:14Z
dc.date.available2021-08-18T08:15:14Z
dc.date.issued2006
dc.description.abstractThe family of IL-10-related cytokines includes several human members, IL-19, IL-20, IL-22, IL-24 and IL-26, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen-specific T cell suppression, survival and expression of surface markers in comparison to IL-10 and cytomegalovirus (CMV)-IL-10. Human CD45RA(+) T cells were stimulated in the presence of IL-10-family cytokines in sequential 12-day cycles. After three to four cycles of stimulation, IL-10 and CMV-IL-10 led to increased IFN-gamma and IL-10 but decreased IL-4 and IL-13. Interestingly, long-term exposure of T cells to IL-19, IL-20 and IL-22 down-regulated IFN-gamma but up-regulated IL-4 and IL-13 in T cells and supported the polarization of naive T cells toTh2-like cells. in contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis. The antigen-specific suppressor activity of IL-10 and CMV-IL-10 was not observed for any of the other IL-10-family cytokines. These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles.en_US
dc.identifier.citationOral, H. B. vd. (2006). ''Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26''. European Journal of Immunology, 36(2), 380-388.en_US
dc.identifier.endpage388tr_TR
dc.identifier.issn0014-2980
dc.identifier.issn1521-4141
dc.identifier.issue2tr_TR
dc.identifier.pubmed16365913tr_TR
dc.identifier.scopus2-s2.0-32944473854tr_TR
dc.identifier.startpage380tr_TR
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425523
dc.identifier.urihttps://doi.org/10.1002/eji.200425523
dc.identifier.urihttp://hdl.handle.net/11452/21459
dc.identifier.volume36tr_TR
dc.identifier.wos000235404500015tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunologyen_US
dc.subjectT cellsen_US
dc.subjectNew cytokinesen_US
dc.subjectInterleukin-10en_US
dc.subjectIfn-gammaen_US
dc.subjectType-1 cellsen_US
dc.subjectStat activationen_US
dc.subjectReceptor complexesen_US
dc.subjectMelanoma differentiationen_US
dc.subjectDifferentiation-associated geneen_US
dc.subjectInducible factoren_US
dc.subjectCutting edgeen_US
dc.subject.scopusInterleukin-22; Human Il26 Protein; Pustulosis Palmoplantarisen_US
dc.subject.wosImmunologyen_US
dc.titleRegulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26en_US
dc.typeArticle
dc.wos.quartileQ1en_US

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