The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study
dc.contributor.author | Yağcı, Artay | |
dc.contributor.author | Sevimli, Alper | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.buuauthor | Oral, Arzu Yılmaztepe | |
dc.contributor.buuauthor | Zık, Berrin | |
dc.contributor.buuauthor | Arı, Ferda | |
dc.contributor.buuauthor | Akgöz, Semra | |
dc.contributor.buuauthor | Ursavaş, Ahmet | |
dc.contributor.buuauthor | Bayer, Sibel | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veterinerlik Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/TB ve Göğüs Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-6729-7908 | tr_TR |
dc.contributor.orcid | 0000-0003-0463-6818 | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.researcherid | AAI-3169-2021 | tr_TR |
dc.contributor.researcherid | AAH-9810-2021 | tr_TR |
dc.contributor.researcherid | AAG-7012-2021 | tr_TR |
dc.contributor.researcherid | A-5841-2017 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.contributor.scopusid | 23091316500 | tr_TR |
dc.contributor.scopusid | 6507763192 | tr_TR |
dc.contributor.scopusid | 24376085300 | tr_TR |
dc.contributor.scopusid | 14061863400 | tr_TR |
dc.contributor.scopusid | 8329319900 | tr_TR |
dc.contributor.scopusid | 57215362032 | tr_TR |
dc.date.accessioned | 2022-06-21T07:45:05Z | |
dc.date.available | 2022-06-21T07:45:05Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Akt/PKB is a protooncogen while PTEN is a tumor suppressor gene. Their expressions are of immense importance in the development of lung cancer. However, little is known about their relations to anti-cancer treatments. Therefore, we aimed to elucidate how are these parameters affected by the treatment. Expression of phosphorylated Akt (pAkt) and PTEN have been analysed on tissues of 32 patients (stage Ill and IV) with lung cancer. In addition, the expression of these variables in 14 out of 32 patients have furtherly been analysed in terms of their response to cisplatin-based chemotherapy in vivo. Prior to and 24 h after the treatment, tumor tissues were obtained via broncoscopy and then evaluated immunohistochemically by indirect streptavidin-biotin peroxidase method. Immunoreactivity for pAkt was detected in 29 of 32 cases (91%). pAkt was observed to localize in the nucleus of positively stained cells. However, PTEN expression was found in 27 of 32 cases (84%). In contrast to the localization of pAkt that is nucleus, PTEN was however localized in the cytoplasm of positively stained cells. pAkt and PTEN expression levels of 14 post-chemotherapy patients were compared to those before chemotherapy. There was no statistically significant differences (p>0.05). Although these results do not imply any possible roles of pAkt or PTEN in the late stage lung cancer patients as a biomarker for the prediction of early response to treatment in vivo, this conclusion needs to be analyzed further at later time points in a larger cohort. | tr_TR |
dc.identifier.citation | Ulukaya, E. vd. (2011). "The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study". UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 21(1), 26-33. | tr_TR |
dc.identifier.endpage | 33 | tr_TR |
dc.identifier.issn | 1306-133X | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.scopus | 2-s2.0-79953677217 | tr_TR |
dc.identifier.startpage | 26 | tr_TR |
dc.identifier.uri | https://doi.org/10.4999/uhod.09105 | |
dc.identifier.uri | http://www.uhod.org/pdf/PDF_451.pdf | |
dc.identifier.uri | http://hdl.handle.net/11452/27331 | |
dc.identifier.volume | 21 | tr_TR |
dc.identifier.wos | 000289140000004 | tr_TR |
dc.indexed.scopus | Scopus | tr_TR |
dc.indexed.trdizin | TrDizin | tr_TR |
dc.indexed.wos | SCIE | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Akad Doktorlar Yayınevi | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.subject | Oncology | tr_TR |
dc.subject | Lung Cancer | tr_TR |
dc.subject | pAkt | tr_TR |
dc.subject | PTEN | tr_TR |
dc.subject | Cisplatin | tr_TR |
dc.subject | Chemotherapy | tr_TR |
dc.subject | Protein-kinase-b | tr_TR |
dc.subject | Prognostic-significance | tr_TR |
dc.subject | Akt activation | tr_TR |
dc.subject | Breast-cancer | tr_TR |
dc.subject | Cell-death | tr_TR |
dc.subject | Apoptosis | tr_TR |
dc.subject | Tumors | tr_TR |
dc.subject | Mechanisms | tr_TR |
dc.subject | Survival | tr_TR |
dc.subject | Gene | tr_TR |
dc.subject | Akciğer kanseri | tr_TR |
dc.subject | Kemoterapi | tr_TR |
dc.subject | Sisplatin | tr_TR |
dc.subject.emtree | Biotin | tr_TR |
dc.subject.emtree | Cisplatin | tr_TR |
dc.subject.emtree | Etoposide | tr_TR |
dc.subject.emtree | Gemcitabine | tr_TR |
dc.subject.emtree | Navelbine | tr_TR |
dc.subject.emtree | Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase | tr_TR |
dc.subject.emtree | Protein kinase B | tr_TR |
dc.subject.emtree | Streptavidin | tr_TR |
dc.subject.emtree | Article | tr_TR |
dc.subject.emtree | Bronchoscopy | tr_TR |
dc.subject.emtree | Cancer tissue | tr_TR |
dc.subject.emtree | Clinical article | tr_TR |
dc.subject.emtree | Controlled study | tr_TR |
dc.subject.emtree | Enzyme localization | tr_TR |
dc.subject.emtree | Human | tr_TR |
dc.subject.emtree | Human tissue | tr_TR |
dc.subject.emtree | Immunohistochemistry | tr_TR |
dc.subject.emtree | Lung non small cell cancer | tr_TR |
dc.subject.emtree | Lung small cell cancer | tr_TR |
dc.subject.emtree | Pilot study | tr_TR |
dc.subject.emtree | Protein expression | tr_TR |
dc.subject.emtree | Protein phosphorylation | tr_TR |
dc.subject.scopus | MK 2206; 3 Phosphoinositide Dependent Protein Kinase; Phosphatidylinositols | tr_TR |
dc.subject.wos | Oncology | tr_TR |
dc.title | The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study | tr_TR |
dc.title.alternative | Akciǧer kanserli hastalarda sisplatin-Bazlı tedaviden 24 saat sonra pAkt ve PTEN ekspresyonları: Prospektif pilot çalışma | tr_TR |
dc.type | Article | |
dc.wos.quartile | Q4 | tr_TR |