Caffeine potentiates the enhancement by choline of striatal acetylcholine release

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dc.contributor.authorJohnson, David A.
dc.contributor.authorWurtman, Richard J.
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.date.accessioned2021-07-12T13:41:16Z
dc.date.available2021-07-12T13:41:16Z
dc.date.issued1992
dc.description.abstractWe investigated the effect of peripherally administered caffeine (50 mg/kg), choline (30, 60, or 120 mg/kg) or combinations of both drugs on the spontaneous release of acetylcholine (ACh) from the corpus striatum of anesthetized rats using in vivo microdialysis. Caffeine alone or choline in the 30 or 60 mg/kg dose failed to increase ACh in microdialysis samples; the 120 mg/kg choline dose significantly enhanced ACh during the 80 min following drug administration. Coadministration of caffeine with choline significantly increased ACh release after each of the choline doses tested. Peak microdialysate levels with the 120 mg/kg dose were increased 112% when caffeine was additionally administered, as compared with 54% without caffeine. These results indicate that choline administration can enhance spontaneous ACh release from neurons, and that caffeine, a drug known to block adenosine receptors on these neurons, can amplify the choline effect.en_US
dc.identifier.citationJohnson, D. A. vd. (1992). ''Caffeine potentiates the enhancement by choline of striatal acetylcholine release''. Life Sciences, 51(20), 1597-1601.en_US
dc.identifier.endpage1601tr_TR
dc.identifier.issn0024-3205
dc.identifier.issue20tr_TR
dc.identifier.pubmed1435067tr_TR
dc.identifier.scopus2-s2.0-0026699548tr_TR
dc.identifier.startpage1597tr_TR
dc.identifier.urihttps://doi.org/10.1016/0024-3205(92)90622-V
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/002432059290622V
dc.identifier.urihttp://hdl.handle.net/11452/21223
dc.identifier.volume51tr_TR
dc.identifier.wosA1992JR51700005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalLife sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain acetylcholineen_US
dc.subjectRat-brainen_US
dc.subjectAdenosineen_US
dc.subjectMicrodialysisen_US
dc.subjectSynaptosomesen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleCaffeine potentiates the enhancement by choline of striatal acetylcholine releaseen_US
dc.typeArticle

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