Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity

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dc.contributor.authorKiran, B. Keerthi
dc.contributor.buuauthorArslan, Birsen Yiğit
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.scopusid56698581000
dc.contributor.scopusid7004271086
dc.contributor.scopusid6603687024
dc.date.accessioned2021-06-21T07:16:56Z
dc.date.available2021-06-21T07:16:56Z
dc.date.issued1991
dc.description.abstractIntracerebroventricular (i.c.v.) injection of choline (50-150-mu-g) increased blood pressure (SP) and decreased heart rate (HR) in freely moving rats. Intracerebroventricular pretreatment of rats with mecamylamine (50-mu-g) blocked the reduction in HR and reduced the increase in SP induced by i.c.v. choline (150-mu-g). Central muscarinic blockade with atropine (10-mu-g, i.c.v.) reduced the pressor response to i.c.v. choline (150-mu-g) by about 70%, without influencing the decrease in HR. The decrease in HR induced by i.c.v. choline was prevented by intraarterial (i.a.) treatment of atropine methylnitrate (2 mg/kg). Intracerebroventricular choline (150-mu-g) produced a fivefold increase in catecholamine concentrations in adrenal venous plasma. Bilateral adrenalectomy reduced, but did not block, choline's effect on SP. Intracerebroventricular choline (150-mu-g) showed an ability to increase and restore SP in rats subjected to spinal cord transection or pretreatment with hexamethonium (15 mg/kg, i.a.) or with phentolamine (10 mg/kg, i.a.). Intracerebroventricular choline (150-mu-g) increased plasma vasopressin (VP) levels from 2.2 +/- 0.4 to 25.6 +/- 2.5 pg/ml. Pretreatment of rats with a VP antagonist reduced the pressor response to i.c.v. choline. It is concluded that (a) the reduction in HR results from a central nicotinic receptor-mediated increase in vagal tone, (b) the increase in SP appears to be due to activation of both nicotinic and muscarinic central cholinergic receptors, and that (c) the central activation of the adrenal medulla and the increase in plasma levels of VP are involved in the pressor response to i.c.v. choline.en_US
dc.identifier.citationArslan, B. Y. vd. (1991). ''Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity''. Journal of Cardiovascular Pharmacology, 17(5), 814-821.tr_TR
dc.identifier.endpage821tr_TR
dc.identifier.issn0160-2446
dc.identifier.issue5tr_TR
dc.identifier.pubmed1713998tr_TR
dc.identifier.scopus2-s2.0-0025797063tr_TR
dc.identifier.startpage814tr_TR
dc.identifier.urihttps://doi.org/10.1097/00005344-199105000-00018
dc.identifier.urihttp://hdl.handle.net/11452/20669
dc.identifier.volume17tr_TR
dc.identifier.wosA1991FH07000018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen
dc.publisherLippincott-Raven Publicationstr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Cardiovascular Pharmacologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholineen_US
dc.subjectCholinergicen_US
dc.subjectBlood pressureen_US
dc.subjectVasopressinen_US
dc.subjectSympathoadrenal activityen_US
dc.subjectTyrosine-hydroxylaseen_US
dc.subjectRat-brainen_US
dc.subjectStimulationen_US
dc.subjectAcetylcholineen_US
dc.subjectMechanismsen_US
dc.subjectReleaseen_US
dc.subjectNeuronsen_US
dc.subjectPhysostigmineen_US
dc.subjectStriatumen_US
dc.subject.emtreeAtropineen_US
dc.subject.emtreeAtropine methyl nitrateen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeExamethoniumen_US
dc.subject.emtreeMecamylamineen_US
dc.subject.emtreePhentolamineen_US
dc.subject.emtreeVasopressin derivativeen_US
dc.subject.emtreeAdrenal medullaen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeIntraarterial drug administrationen_US
dc.subject.emtreeIntracerebroventricular drug administrationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSympathetic functionen_US
dc.subject.emtreeVasopressin blood levelen_US
dc.subject.meshAdrenal glandsen_US
dc.subject.meshAdrenalectomyen_US
dc.subject.meshAdrenergic alpha-antagonistsen_US
dc.subject.meshAnimalen_US
dc.subject.meshAtropineen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshCardiovascular systemen_US
dc.subject.meshCholineen_US
dc.subject.meshDose-response relationshipen_US
dc.subject.meshDrugen_US
dc.subject.meshInjectionsen_US
dc.subject.meshIntraperitonealen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshMale; Mecamylamineen_US
dc.subject.meshRatsen_US
dc.subject.meshCholinergicen_US
dc.subject.meshReceptorsen_US
dc.subject.meshReninen_US
dc.subject.meshSpinal corden_US
dc.subject.meshSupport, Non-U.S. Gov'ten_US
dc.subject.meshSympathetic nervous systemen_US
dc.subject.meshVasopressinsen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleEffects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activityen_US
dc.typeArticle

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