The role of ADAMTS1 and versican in human myocardial infarction: A postmortem study

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dc.contributor.authorPehlivan, Sultan
dc.contributor.authorAkyol, Sümeyya
dc.contributor.authorEren, Filiz
dc.contributor.authorGüleç, Mehmet Akif
dc.contributor.authorEren, Bülent
dc.contributor.authorDemircan, Kadir
dc.contributor.authorAkyol, Ömer
dc.contributor.buuauthorGürses, Murat Serdar
dc.contributor.buuauthorUral, Mustafa Numan
dc.contributor.buuauthorİnanır, Nursel Türkmen
dc.contributor.buuauthorFedakar, Recep
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9982-0476tr_TR
dc.contributor.orcid0000-0002-4047-6455tr_TR
dc.contributor.researcheridAAH-6287-2021tr_TR
dc.contributor.researcheridAAC-8913-2020tr_TR
dc.contributor.scopusid55979536300tr_TR
dc.contributor.scopusid57163358100tr_TR
dc.contributor.scopusid57188706721tr_TR
dc.contributor.scopusid8725968900tr_TR
dc.date.accessioned2023-04-06T12:17:10Z
dc.date.available2023-04-06T12:17:10Z
dc.date.issued2016-08
dc.description.abstractObjective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.en_US
dc.identifier.citationPehlivan, S. vd. (2016). "The role of ADAMTS1 and versican in human myocardial infarction: A postmortem study". Laboratory Medicine, 47(3), 205-212.en_US
dc.identifier.endpage212tr_TR
dc.identifier.issn0007-5027
dc.identifier.issn1943-7730
dc.identifier.issue3tr_TR
dc.identifier.pubmed27346868tr_TR
dc.identifier.scopus2-s2.0-85014440250tr_TR
dc.identifier.startpage205tr_TR
dc.identifier.urihttps://doi.org/10.1093/labmed/lmw022
dc.identifier.urihttps://academic.oup.com/labmed/article/47/3/205/2453835
dc.identifier.urihttp://hdl.handle.net/11452/32234
dc.identifier.volume47tr_TR
dc.identifier.wos000381879800007
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOxford Universityen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalLaboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectADAMTS1en_US
dc.subjectMyocardial infarctionen_US
dc.subjectVersicanen_US
dc.subjectFragmented versicanen_US
dc.subjectPostmortemen_US
dc.subjectDiagnosisen_US
dc.subjectSudden cardiac deathen_US
dc.subjectHeart-failureen_US
dc.subjectEndothelial-cellsen_US
dc.subjectStable anginaen_US
dc.subjectGeneen_US
dc.subjectExpressionen_US
dc.subjectFamilyen_US
dc.subjectAssociationen_US
dc.subjectMotifsen_US
dc.subject.emtreeADAMTS1 proteinen_US
dc.subject.emtreeVersicanen_US
dc.subject.emtreeADAMTS1 proteinen_US
dc.subject.emtreeADAMTS1 protein, humanen_US
dc.subject.emtreeVCAN protein, humanen_US
dc.subject.emtreeVersicanen_US
dc.subject.emtreeAdipose tissueen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutopsyen_US
dc.subject.emtreeCarboxy terminal sequenceen_US
dc.subject.emtreeCell degenerationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytolysisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHearten_US
dc.subject.emtreeHeart infarctionen_US
dc.subject.emtreeHeart interstitiumen_US
dc.subject.emtreeHeart muscle necrosisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMuscle cellen_US
dc.subject.emtreeMuscle fibrilen_US
dc.subject.emtreeMyocytolysisen_US
dc.subject.emtreeNerve fiberen_US
dc.subject.emtreeNeutrophil chemotaxisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeVacuolar degenerationen_US
dc.subject.emtreeVascular endotheliumen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeCardiac muscleen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeHeart infarctionen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshADAMTS1 proteinen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMyocardial infarctionen_US
dc.subject.meshMyocardiumen_US
dc.subject.meshPathologyen_US
dc.subject.meshVersicansen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusProtein; Disintegrins; Aggrecanaseen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleThe role of ADAMTS1 and versican in human myocardial infarction: A postmortem studyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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