Oral antibody to interleukin-10 reduces growth rate depression due to Eimeria spp. infection in broiler chickens

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dc.contributor.authorSand, Jordan M.
dc.contributor.authorArendt, Maria K.
dc.contributor.authorRepasy, Alec
dc.contributor.authorCook, Mark E.
dc.contributor.buuauthorDeniz, Gülay
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.scopusid8849978100tr_TR
dc.date.accessioned2022-10-05T08:44:01Z
dc.date.available2022-10-05T08:44:01Z
dc.date.issued2015-11-05
dc.description.abstractEimeria spp. must be controlled in floor-reared poultry to prevent the onset of coccidiosis. Here we use an oral antibody to chicken IL-10 to prevent growth depression due to Eimeria spp. infection. Egg antibody directed against an antigenic peptide of IL-10 was produced in laying hens and measured using an ELISA. In the first experiment, egg yolk powder containing antibody to chicken IL-10 (vlpramqt conjugate) (anti-IL-10 yolk powder) was fed at 3.4 g/kg feed to determine growth response following mixed Eimeria spp. challenge. Chicks were fed either anti-IL-10 antibodies or control antibodies and challenged (d3) with either sterile saline or a 10x attenuated Eimeria spp. vaccine. Control-fed and Eimeria-challenged chicks grew 8.8% slower than those challenged with saline (P < 0.04), whereas anti-IL-10-fed Eimeria challenged chicks were not different from untreated controls. In the second trial a dose response was performed with doses of either 0 (control antibody), 0.34-, or 3.4-g anti-IL-10 yolk powder/kg feed. Control-fed, Eimeria-challenged chicks grew 10.6% slower than control saline-challenged chicks (P < 0.05); however, anti-IL-10-fed chicks fed either dose of anti-IL-10 were not different from saline-challenged chicks. Finally, the effect of anti-IL-10 on acquired immunity was investigated. Chicks were fed control or anti-IL-10 yolk powder and vaccinated with a 1x dose of Eimeria vaccine at d 3. After 14 d, antibody was removed from the diet. Chicks were either saline or 10x Eimeria challenged at d 17. We found that the anti-IL-10-fed chickens did not show a reduction in growth due to challenge; hence anti-IL-10 does not appear to affect adaptive immunity during the primary immunization. Overall, use of an antibody to IL-10 is a novel method in preventing adverse effects of Eimeria spp. infection in poultry.en_US
dc.description.sponsorshipWisconsin Alumni Research Foundation (WARF) Accelerator Granten_US
dc.description.sponsorshipCollege of Agricultural and Life Sciencesen_US
dc.description.sponsorshipUnited States Department of Health & Human Services - T32OD010423en_US
dc.description.sponsorshipNational Institutes of Health (NIH) - USAen_US
dc.identifier.citationSand, J. M. vd. (2015). "Oral antibody to interleukin-10 reduces growth rate depression due to Eimeria spp. infection in broiler chickens". Poultry Science, 95(2), 439-446.en_US
dc.identifier.endpage446tr_TR
dc.identifier.issn0032-5791
dc.identifier.issn1525-3171
dc.identifier.issue2tr_TR
dc.identifier.pubmed26772659tr_TR
dc.identifier.scopus2-s2.0-84963877373tr_TR
dc.identifier.startpage439tr_TR
dc.identifier.urihttps://doi.org/10.3382/ps/pev352
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0032579119321637
dc.identifier.urihttp://hdl.handle.net/11452/28968
dc.identifier.volume95tr_TR
dc.identifier.wos000371060000022tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalPoultry Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgricultureen_US
dc.subjectCoccidiosisen_US
dc.subjectEgg antibodyen_US
dc.subjectAnti-IL-10en_US
dc.subjectChickenen_US
dc.subjectEimeriaen_US
dc.subjectMigration inhibitory factoren_US
dc.subjectCytokineen_US
dc.subjectExpressionen_US
dc.subjectImmunityen_US
dc.subjectReceptoren_US
dc.subjectIl-10en_US
dc.subject.emtreeAvian proteinen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeProtozoon antibodyen_US
dc.subject.emtreeAnalysisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAnimal fooden_US
dc.subject.emtreeChickenen_US
dc.subject.emtreeCoccidiosisen_US
dc.subject.emtreeDieten_US
dc.subject.emtreeEimeriaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGrowth, development and agingen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeParasitologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreePoultry diseasesen_US
dc.subject.emtreeVeterinaryen_US
dc.subject.meshAnimal feeden_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, protozoanen_US
dc.subject.meshAvian proteinsen_US
dc.subject.meshChickensen_US
dc.subject.meshCoccidiosisen_US
dc.subject.meshDieten_US
dc.subject.meshEimeriaen_US
dc.subject.meshFemaleen_US
dc.subject.meshInterleukin-10en_US
dc.subject.meshPoultry diseasesen_US
dc.subject.scopusEimeria Tenella; Chicken; Coccidiostatic Agenten_US
dc.subject.wosAgriculture, dairy & animal scienceen_US
dc.titleOral antibody to interleukin-10 reduces growth rate depression due to Eimeria spp. infection in broiler chickensen_US
dc.typeArticle

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