Genotoxic, hematoxic, pathological, and biochemical effects of hexane on Swiss Albino rats
dc.contributor.buuauthor | Egeli, Ünal | |
dc.contributor.buuauthor | Tunca, Berrin | |
dc.contributor.buuauthor | Tuncel, Pınar | |
dc.contributor.buuauthor | Kahraman, Müfit | |
dc.contributor.buuauthor | Sevinir, Betül | |
dc.contributor.buuauthor | Çeçener, Gülşah | |
dc.contributor.buuauthor | Batmaz, Hasan | |
dc.contributor.buuauthor | Akpınar, Gürler | |
dc.contributor.buuauthor | Çimen, Çiğdem | |
dc.contributor.buuauthor | Cangül, Taci | |
dc.contributor.buuauthor | Bilaloğlu, Rahmi | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Onkoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-3820-424X | tr_TR |
dc.contributor.orcid | 0000-0002-1619-6680 | tr_TR |
dc.contributor.orcid | 0000-0003-1991-8957 | tr_TR |
dc.contributor.orcid | 0000-0002-9675-3714 | tr_TR |
dc.contributor.orcid | 0000-0003-0537-2113 | tr_TR |
dc.contributor.researcherid | AAP-9988-2020 | tr_TR |
dc.contributor.researcherid | ABI-6078-2020 | tr_TR |
dc.contributor.researcherid | AAH-1712-2021 | tr_TR |
dc.contributor.researcherid | AAH-1570-2021 | tr_TR |
dc.contributor.researcherid | F-7337-2018 | tr_TR |
dc.contributor.researcherid | AAB-4360-2021 | tr_TR |
dc.contributor.scopusid | 55665145000 | tr_TR |
dc.contributor.scopusid | 6602965754 | tr_TR |
dc.contributor.scopusid | 7801598700 | tr_TR |
dc.contributor.scopusid | 6701778876 | tr_TR |
dc.contributor.scopusid | 6603199915 | tr_TR |
dc.contributor.scopusid | 6508156530 | tr_TR |
dc.contributor.scopusid | 6602783183 | tr_TR |
dc.contributor.scopusid | 8327546900 | tr_TR |
dc.contributor.scopusid | 6506092143 | tr_TR |
dc.contributor.scopusid | 23102218300 | tr_TR |
dc.contributor.scopusid | 6505804122 | tr_TR |
dc.date.accessioned | 2022-03-31T08:00:03Z | |
dc.date.available | 2022-03-31T08:00:03Z | |
dc.date.issued | 2000 | |
dc.description.abstract | In the present study, the genotoxic, hematoxic effects, and their relation with pathological and biochemical parameters of hexane were investigated. Cytogenetic evaluation performed on the bone marrow indicated that chromosome aberrations increased at both hexane doses in relation to the negative controls. Decreased hematocrit, hemoglobin concentrations, and mean corpuscular volume were observed on the whole blood counts. Conjugated dienes (CD), glutathione (GSH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and catalase (CAT) were increased. Histological examinations showed intracytoplasmic vacuolisation, nuclei with lower chromatin, and parenchymatous degenerations in the dose groups. In the bone marrow slides, depletion of the erythroid series were observed. In conclusion, hexane seems to be a genotoxic and hematoxic agent leading to degeneration and lipid peroxidation in exposed groups. Teratogenesis Carcinog. Mutagen. | en_US |
dc.identifier.citation | Egeli, Ü. vd. (2000). "Genotoxic, hematoxic, pathological, and biochemical effects of hexane on Swiss Albino rats". Teratogenesis Carcinogenesis and Mutagenesis, 20(6), 329-340. | en_US |
dc.identifier.endpage | 340 | tr_TR |
dc.identifier.issn | 0270-3211 | |
dc.identifier.issue | 6 | tr_TR |
dc.identifier.pubmed | 11074517 | tr_TR |
dc.identifier.scopus | 2-s2.0-0033724984 | tr_TR |
dc.identifier.startpage | 329 | tr_TR |
dc.identifier.uri | https://doi.org/10.1002/1520-6866(2000)20:6<329::AID-TCM2>3.0.CO;2-M | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/1520-6866(2000)20:6%3C329::AID-TCM2%3E3.0.CO;2-M | |
dc.identifier.uri | http://hdl.handle.net/11452/25482 | |
dc.identifier.volume | 20 | tr_TR |
dc.identifier.wos | 000165421900002 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Liss | en_US |
dc.relation.journal | Teratogenesis Carcinogenesis and Mutagenesis | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Oncology | en_US |
dc.subject | Genetics & heredity | en_US |
dc.subject | Toxicology | en_US |
dc.subject | Hexane | en_US |
dc.subject | Genotoxic effect | en_US |
dc.subject | Hemotoxic effect | en_US |
dc.subject | Pathological effect | en_US |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Exposed long-term | en_US |
dc.subject | Chromosomal-aberrations | en_US |
dc.subject | Genetic predisposition | en_US |
dc.subject | Marker proteins | en_US |
dc.subject | N-hexane | en_US |
dc.subject | Toluene | en_US |
dc.subject | Neurotoxicity | en_US |
dc.subject | Expression | en_US |
dc.subject | Induction | en_US |
dc.subject | Benzene | en_US |
dc.subject | Animalia | en_US |
dc.subject | Felis catus | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | Alkadiene | en_US |
dc.subject.emtree | Aspartate aminotransferase | en_US |
dc.subject.emtree | Catalase | en_US |
dc.subject.emtree | Glutathione | en_US |
dc.subject.emtree | Hemoglobin | en_US |
dc.subject.emtree | Hexane | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood toxicity | en_US |
dc.subject.emtree | Bone marrow | en_US |
dc.subject.emtree | Cell vacuole | en_US |
dc.subject.emtree | Chromatin | en_US |
dc.subject.emtree | Chromosome aberration | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Cytogenetics | en_US |
dc.subject.emtree | Degeneration | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Genotoxicity | en_US |
dc.subject.emtree | Hematocrit | en_US |
dc.subject.emtree | Hemoglobin determination | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Lipid peroxidation | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mean corpuscular volume | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.scopus | Xylenes; Toluene; Ethylbenzene | en_US |
dc.subject.wos | Oncology | tr_TR |
dc.subject.wos | Genetics & heredity | en_US |
dc.subject.wos | Toxicology | en_US |
dc.title | Genotoxic, hematoxic, pathological, and biochemical effects of hexane on Swiss Albino rats | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 (Genetics & heredity) | en_US |
dc.wos.quartile | Q3 | en_US |
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