XRCC1 gene polymorphisms and risk of lung cancer in Turkish patients

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dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorDeligönül, Adem
dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorKurt, Ender
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorÇubukcu, Erdem
dc.contributor.buuauthorŞehitoğlu, İbrahim
dc.contributor.buuauthorCanhoroz, Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.researcheridAAH-5180-2021tr_TR
dc.contributor.researcheridABF-8955-2021tr_TR
dc.contributor.scopusid35388323500tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid37088030300tr_TR
dc.contributor.scopusid6505944216tr_TR
dc.contributor.scopusid15832295800tr_TR
dc.contributor.scopusid7006207332tr_TR
dc.contributor.scopusid55881548500tr_TR
dc.contributor.scopusid53986153800tr_TR
dc.contributor.scopusid36553239400tr_TR
dc.contributor.scopusid52663246200tr_TR
dc.date.accessioned2022-03-31T10:35:17Z
dc.date.available2022-03-31T10:35:17Z
dc.date.issued2012-06
dc.description.abstractPolymorphisms in the X-ray repair cross complementing 1 (XRCC1) gene have been found to be associated with susceptibility to various types of cancers. We investigated the association between the XRCC1 gene Arg399Gln polymorphism and the susceptibility to lung cancer in Turkish patients. To determine the association of this polymorphism with the risk of lung cancer in Turkish patients, a hospital-based case-control study was designed, involving 67 patients with lung cancer and 60 control subjects with no cancer history who were matched for age and gender. XRCC1 genotypes (Arg/Arg, Arg/Gln, and Gln/Gln) were determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis on genomic DNA. No statistically significant relationship was determined between the lung cancer and control groups (p>0.05). Among the patients, 61% were Arg/Arg, 28% were Arg/Gln, and 11% were Gln/Gln. Among the controls, 50% were Arg/Arg, 38% were Arg/Gln, and 12% were Gln/Gln. There was no difference in the distribution of XRCC1 genotypes or the frequencies of the Arg (75% versus 69%) and Gln (25% versus 31%) alleles between the lung cancer patients and controls. Our results suggest that the XRCC1 gene Arg399Gln polymorphism is not associated with an increased risk for the development of lung cancer in Turkish patients.en_US
dc.identifier.citationKarkucak, M. vd. (2012). "XRCC1 gene polymorphisms and risk of lung cancer in Turkish patients". International Journal of Human Genetics, 12(2), 113-117.en_US
dc.identifier.endpage117tr_TR
dc.identifier.issn0972-3757
dc.identifier.issue2tr_TR
dc.identifier.scopus2-s2.0-84863491193tr_TR
dc.identifier.startpage113tr_TR
dc.identifier.urihttps://doi.org/10.1080/09723757.2012.11886171
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/09723757.2012.11886171
dc.identifier.urihttp://hdl.handle.net/11452/25491
dc.identifier.volume12tr_TR
dc.identifier.wos000307090500006tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.journalInternational Journal of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenetics & heredityen_US
dc.subjectPolymorphismen_US
dc.subjectXRCC1en_US
dc.subjectLung canceren_US
dc.subjectDna-repair genesen_US
dc.subjectExcision-repairen_US
dc.subjectPopulationen_US
dc.subjectXpden_US
dc.subjectSusceptibilityen_US
dc.subjectAssociationen_US
dc.subjectMetaanalysisen_US
dc.subjectFrequencyen_US
dc.subjectPathwayen_US
dc.subject.emtreeGenomic dnaen_US
dc.subject.emtreeXRCC1 proteinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer geneticsen_US
dc.subject.emtreeCancer risken_US
dc.subject.emtreeCancer susceptibilityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic risken_US
dc.subject.emtreeHospital based case control studyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLung canceren_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeX ray repair cross complementing 1 geneen_US
dc.subject.scopusXeroderma Pigmentosum; DNA Repair; Glycosylasesen_US
dc.subject.wosGenetics & heredityen_US
dc.titleXRCC1 gene polymorphisms and risk of lung cancer in Turkish patientsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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