Severe fetal valproate syndrome: Combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly

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dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.buuauthorYapıcı, Şenay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8393-2021tr_TR
dc.contributor.scopusid16679325400tr_TR
dc.contributor.scopusid23994946300tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.contributor.scopusid37000234300tr_TR
dc.date.accessioned2021-12-23T11:28:50Z
dc.date.available2021-12-23T11:28:50Z
dc.date.issued2011-03
dc.description.abstractValproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders. Fetal valproate syndrome (FVS) is characterized by a number of abnormalities associated with VPA exposure in utero including neural tube defects, congenital heart defects, limb defects, genitourinary defects, brain, eye and respiratory anomalies, and abdominal wall defects. Complex cardiac defect and trigonocephaly have rarely been reported and multicystic dysplastic kidney has never been detected in FVS. We here report a female infant who was born to a mother with a history of low-dose VPA monotherapy (250 mg/day) during pregnancy and who had presented with a combination of unilateral multicystic dysplastic kidney, multicomplex cardiac defect including severe coarctation of aorta, Ebstein anomaly, secundum atrial septal defect, mesocardia along with trigonocephaly due to metopic craniosynostosis, typical facial appearance and limb defects. To our knowledge, this is the first case presented with multicystic dysplastic kidney, complex cardiac defect, trigonocephaly and other limb and facial defects because of exposure to very low-dose VPA monotherapy (250 mg/day) in utero. We conclude that VPA must be used very cautiously in pregnant women even as monotherapy and in low doses to prevent major congenital defects.en_US
dc.identifier.citationÖzkan, H. vd. (2011). "Severe fetal valproate syndrome: Combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly". Journal of Maternal-Fetal and Neonatal Medicine, 24(3), 521-524.en_US
dc.identifier.endpage524tr_TR
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue3tr_TR
dc.identifier.pubmed21291342tr_TR
dc.identifier.scopus2-s2.0-79751504241tr_TR
dc.identifier.startpage521tr_TR
dc.identifier.urihttps://doi.org/10.3109/14767058.2010.501120
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/14767058.2010.501120
dc.identifier.urihttp://hdl.handle.net/11452/23507
dc.identifier.volume24tr_TR
dc.identifier.wos000286993000028tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectAntiepileptic drugsen_US
dc.subjectSodium valproateen_US
dc.subjectPregnancyen_US
dc.subjectExposureen_US
dc.subjectEpilepsyen_US
dc.subjectTeratogenicityen_US
dc.subjectAbnormalitiesen_US
dc.subjectMalformationsen_US
dc.subjectRegisteren_US
dc.subjectAplasiaen_US
dc.subject.emtreeValproic aciden_US
dc.subject.emtreeAbsenceen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeApgar scoreen_US
dc.subject.emtreeArachnodactylyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeArtificial ventilationen_US
dc.subject.emtreeBirth weighten_US
dc.subject.emtreeBody heighten_US
dc.subject.emtreeBrain malformationen_US
dc.subject.emtreeCamptodactylyen_US
dc.subject.emtreeCardiomegalyen_US
dc.subject.emtreeCase reporten_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeCongenital heart malformationen_US
dc.subject.emtreeCraniofacial synostosisen_US
dc.subject.emtreeDrug induced diseaseen_US
dc.subject.emtreeEbstein anomalyen_US
dc.subject.emtreeEndotracheal intubationen_US
dc.subject.emtreeFaciesen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFetal valproate syndromeen_US
dc.subject.emtreeFetus echographyen_US
dc.subject.emtreeFrontal bossingen_US
dc.subject.emtreeFunnel chesten_US
dc.subject.emtreeHead circumferenceen_US
dc.subject.emtreeHeart atrium septum defecten_US
dc.subject.emtreeHeart right ventricle hypertrophyen_US
dc.subject.emtreeHigh arched palateen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHydrocephalusen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeKidney hypoplasiaen_US
dc.subject.emtreeLimb defecten_US
dc.subject.emtreeLow drug doseen_US
dc.subject.emtreeLow set earen_US
dc.subject.emtreeMesocardiaen_US
dc.subject.emtreeMicrophthalmiaen_US
dc.subject.emtreeMouth malformationen_US
dc.subject.emtreeMulticystic dysplastic kidneyen_US
dc.subject.emtreeMuscle hypotoniaen_US
dc.subject.emtreeNeonatal respiratory distress syndromeen_US
dc.subject.emtreePrenatal drug exposureen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePulmonary valve stenosisen_US
dc.subject.emtreeRespiratory failureen_US
dc.subject.emtreeTeratogenicityen_US
dc.subject.emtreeTrigonocephalyen_US
dc.subject.meshAbnormalities, drug-induceden_US
dc.subject.meshAbnormalities, multipleen_US
dc.subject.meshCraniosynostosesen_US
dc.subject.meshFatal outcomeen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart defects, congenitalen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshLimb deformities, congenitalen_US
dc.subject.meshMulticystic dysplastic kidneyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal exposure delayed effectsen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshValproic aciden_US
dc.subject.meshYoung adulten_US
dc.subject.scopusAnticonvulsants; Valproic Acid; Lamotrigineen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleSevere fetal valproate syndrome: Combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephalyen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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