Clozapine inhibits development and expression of nicotine-induced locomotor sensitization in rats

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dc.contributor.authorKayır, Hakan
dc.contributor.authorYıldırım, Murat
dc.contributor.authorUzbay, Tayfun
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2021-12-07T08:05:02Z
dc.date.available2021-12-07T08:05:02Z
dc.date.issued2009-01
dc.description.abstractIt has been shown that clozapine, the prototype of atypical antipsychotics, significantly reduces daily cigarette use and alcohol consumption in schizophrenic patients. However, our knowledge about the effect of clozapine on nicotine abuse is limited. Aim of this study was to determine whether clozapine would inhibit the development and expression of nicotine-induced locomotor sensitization in rats. To investigate the effect of clozapine on the development of nicotine-induced locomotor sensitization, rats were pretreated with clozapine (2.5-10 mg/kg) 30 min before the nicotine (0.5 mg/kg), and locomotor activity was recorded for 15 min. This procedure was repeated every day for eight sessions. After a 3-day drug-free period, rats were challenged with nicotine (0.5 mg/kg). To reveal effect of clozapine on the expression of nicotine-induced locomotor sensitization, rats were injected with nicotine for eight sessions. After a 3-day drug-free period, rats were pretreated with clozapine (2.5-10 mg/kg) or vehicle 30 min before the nicotine (0.5 mg/kg) challenge injection. Repeated administration or nicotine generated robust locomotor sensitization in rats. Clozapine pretreatment (2.5-10 mg/kg) blocked the development and the expression of nicotine-induced locomotor sensitization in rats. Our results suggest that atypical antipsychotic clozapine can prevent the effects of nicotine in an animal model of dependence, which represents early adaptations in initiation and continuation of addictive behavior.en_US
dc.identifier.citationKayır, H. vd. (2009). "Clozapine inhibits development and expression of nicotine-induced locomotor sensitization in rats". Synapse, 63(1), 15-21.en_US
dc.identifier.endpage21tr_TR
dc.identifier.issn0887-4476
dc.identifier.issn1098-2396
dc.identifier.issue1tr_TR
dc.identifier.pubmed18925656tr_TR
dc.identifier.scopus2-s2.0-58149479870tr_TR
dc.identifier.startpage15tr_TR
dc.identifier.urihttps://doi.org/10.1002/syn.20576
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/syn.20576
dc.identifier.urihttp://hdl.handle.net/11452/23035
dc.identifier.volume63tr_TR
dc.identifier.wos000261658400003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalSynapseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak105S387tr_TR
dc.relation.tubitakSBAG-3194tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClozapineen_US
dc.subjectLocomotor sensitizationen_US
dc.subjectNicotineen_US
dc.subjectRat(s)en_US
dc.subjectSubstance dependenceen_US
dc.subjectInduced behavioral sensitizationen_US
dc.subjectIncentive-sensitizationen_US
dc.subjectAntipsychotic-drugsen_US
dc.subjectReceptor antagonisten_US
dc.subjectCognitive functionen_US
dc.subjectNucleus-accumbensen_US
dc.subjectDopamine releaseen_US
dc.subjectSubstance-abuseen_US
dc.subjectNitric-oxideen_US
dc.subjectSchizophreniaen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.emtreeClozapineen_US
dc.subject.emtreeNicotineen_US
dc.subject.emtreeAdaptationen_US
dc.subject.emtreeAddictionen_US
dc.subject.emtreeAnimal behavioren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehavior changeen_US
dc.subject.emtreeCigarette smokingen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeLocomotionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSensitizationen_US
dc.subject.emtreeTobacco dependenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClozapineen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshGene expression regulationen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor activityen_US
dc.subject.meshNeural inhibitionen_US
dc.subject.meshNicotineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.scopusMethylphenidate; Sensitization; Cocaineen_US
dc.subject.wosNeurosciencesen_US
dc.titleClozapine inhibits development and expression of nicotine-induced locomotor sensitization in ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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