Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats

Simple item page
dc.contributor.buuauthorİpekoğlu, S. Z.
dc.contributor.buuauthorBüyükuysal, Levent
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirurji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.scopusid6508227135tr_TR
dc.contributor.scopusid6507171811tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.contributor.scopusid7004641343tr_TR
dc.date.accessioned2021-10-15T12:26:46Z
dc.date.available2021-10-15T12:26:46Z
dc.date.issued2000
dc.description.abstractFemale Sprague-Dawley rats underwent aspirative lesion of the fimbria to produce septohippocampal disconnection Two weeks after the lesion surgery, fetal septal grafts prepared from ventral forebrain of 13-15 days old fetuses of the same outbred strain were placed into the lesion cavity (grafted group). Three months after grafting, all rats were tested for spontaneous motor activity (SMA), step through passive avoidance (STPA) acid in Morris' water maze (MWM). Six months after grafting, both basal and stimulated acetylcholine (ACh) and choline (Ch) release and their tissue levels were measured in ipsilateral hippocampal slices. Septohippocampal disconnection caused a significant impairment in Morris' water maze tasks, but did not alter spontaneous motor activity and step through passive avoidance. Fimbrial lesion, moreover, also declined both stimulated ACh release and tissue ACh levels in hippocampal slices. While lesion-induced change in Morris' water maze was ameliorated partially, declines in both stimulated ACh release and tissue ACh levels were raised to the control levels by fetal septal graft placed into the lesion cavity. These data show that grafted cholinergic neurons can work biochemically which may not result with a complete behavioral amelioration which is, in fact something more complex.en_US
dc.identifier.citationİpekoğlu, S. Z. vd. (2000). "Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats". Journal of Neural Transmission, 107(2), 191-202.en_US
dc.identifier.endpage202tr_TR
dc.identifier.issn0300-9564
dc.identifier.issn1435-1463
dc.identifier.issue2tr_TR
dc.identifier.pubmed10847560tr_TR
dc.identifier.scopus2-s2.0-0033952757tr_TR
dc.identifier.startpage191tr_TR
dc.identifier.urihttps://doi.org/10.1007/s007020050017
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs007020050017
dc.identifier.urihttp://hdl.handle.net/11452/22378
dc.identifier.volume107tr_TR
dc.identifier.wos000085235000007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.journalJournal of Neural Transmissionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectBrain tissue transplantationen_US
dc.subjectAcetylcholineen_US
dc.subjectFimbriaen_US
dc.subjectBehavioren_US
dc.subjectHippocampusen_US
dc.subjectNucleus basalis magnocellularisen_US
dc.subjectNeural transplantationen_US
dc.subjectFornix lesionsen_US
dc.subjectDeficitsen_US
dc.subjectRecoveryen_US
dc.subjectScopolamineen_US
dc.subjectImpairmentsen_US
dc.subjectNeuronsen_US
dc.subjectMonkeysen_US
dc.subjectBrainen_US
dc.subject.emtreeAcetylcholineen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAvoidance behavioren_US
dc.subject.emtreeBrain injuryen_US
dc.subject.emtreeBrain tissueen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeForebrainen_US
dc.subject.emtreeHippocampusen_US
dc.subject.emtreeLearningen_US
dc.subject.emtreeMaze testen_US
dc.subject.emtreeMemoryen_US
dc.subject.emtreeMotor activityen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTissue graften_US
dc.subject.emtreeTissue levelen_US
dc.subject.scopus192 Igg-Saporin; Cholinergic Neurons; Basal Forebrainen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleEffects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected ratsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus