Effects of systemic chlorogenic acid on random-pattern dorsal skin flap survival in diabetic rats

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dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorÇam, Betül Etöz
dc.contributor.buuauthorİnan, Sevda
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorÖzyiğit, Musa Özgür
dc.contributor.buuauthorGül, Zülfiye
dc.contributor.buuauthorBüyükcoşkun, Naciye
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Birimi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.orcid0000-0001-8138-5851tr_TR
dc.contributor.orcid0000-0002-8872-0074tr_TR
dc.contributor.researcheridAAF-9939-2020tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.researcheridAAH-2873-2021tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.researcheridE-3364-2018tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.contributor.scopusid15062425700tr_TR
dc.contributor.scopusid24179406800tr_TR
dc.contributor.scopusid56320836200tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid6507338060tr_TR
dc.contributor.scopusid56086542900tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2022-08-19T06:54:07Z
dc.date.available2022-08-19T06:54:07Z
dc.date.issued2014-03
dc.description.abstractThere has been considerable interest in understanding the effects of antioxidants in flap survival during diabetes. Previous studies showed that chlorogenic acid (CGA) exhibits potent antioxidant effects. We aimed to determine the effects of systemic CGA treatment on skin flap survival in an experimental random-pattern dorsal skin flap model in diabetic rats. Twenty-eight male Wistar rats were divided into four groups: phosphate buffered saline (PBS)-treated or CGA-treated nondiabetic rats, PBS-treated or CGA-treated diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg). Caudally based bipedicled dorsal skin flaps were elevated. CGA (100 mg/kg) or PBS (mL/kg; as vehicle) was administered intraperitoneally once daily. On postoperative day 7, flap survival, regional blood perfusion and microangiography were evaluated. The malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels were evaluated from the flap tissue. Capillary density and vascular endothelial growth factor (VEGF) expression were assessed. Harmful effects of diabetes on flap survival were observed. CGA attenuated these effects and allowed greater survival and blood perfusion. CGA decreased MDA and NO levels and increased GSH and SOD levels. CGA elevated capillary density and VEGF expression. This study showed that peripherally administered CGA significantly improved flap survival in diabetic and nondiabetic rats.en_US
dc.identifier.citationBağdaş, D. vd. (2014). "Effects of systemic chlorogenic acid on random-pattern dorsal skin flap survival in diabetic rats". 37(3), 361-370.en_US
dc.identifier.endpage370tr_TR
dc.identifier.issn0918-6158
dc.identifier.issue3tr_TR
dc.identifier.pubmed24389556tr_TR
dc.identifier.scopus2-s2.0-84897007061tr_TR
dc.identifier.startpage361tr_TR
dc.identifier.urihttps://doi.org/10.1248/bpb.b13-00635
dc.identifier.urihttps://www.jstage.jst.go.jp/article/bpb/advpub/0/advpub_b13-00635/_article/-char/ja/
dc.identifier.urihttp://hdl.handle.net/11452/28273
dc.identifier.volume37tr_TR
dc.identifier.wos000332057600005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Japanen_US
dc.relation.bapKUAP (T) 2012/37tr_TR
dc.relation.journalBiological and Pharmaceutical Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectChlorogenic aciden_US
dc.subjectDiabetesen_US
dc.subjectDorsal skin flapen_US
dc.subjectFlap survivalen_US
dc.subjectOxidative stressen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectEndothelial growth-factoren_US
dc.subjectNitric-oxideen_US
dc.subjectCaffeic aciden_US
dc.subjectPhenethyl esteren_US
dc.subjectBlood-flowen_US
dc.subjectNecrosisen_US
dc.subjectStreptozotocinen_US
dc.subjectInvolvementen_US
dc.subjectModelen_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeGlutathioneen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeStreptozocinen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeVasculotropinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCapillary densityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeGraft perfusionen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMicroangiographyen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSkin flap survivalen_US
dc.subject.emtreeWeight changeen_US
dc.subject.emtreeWistar raten_US
dc.subject.emtreeWound healingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshCapillariesen_US
dc.subject.meshChlorogenic aciden_US
dc.subject.meshDermatologic surgical proceduresen_US
dc.subject.meshDiabetes mellitus, experimentalen_US
dc.subject.meshGlutathioneen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshNitric oxideen_US
dc.subject.meshPlant extractsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReference valuesen_US
dc.subject.meshSkinen_US
dc.subject.meshSuperoxide dismutaseen_US
dc.subject.meshSurgical flapsen_US
dc.subject.meshVascular endothelial growth factor Aen_US
dc.subject.scopusFlaps (Control Surfaces); Perforator Flap; Reperfusion Injuryen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleEffects of systemic chlorogenic acid on random-pattern dorsal skin flap survival in diabetic ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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