Tear function and ocular surface changes in keratoconus

Simple item page
dc.contributor.authorTsubota, Kazuo
dc.contributor.buuauthorDoğru, Murat
dc.contributor.buuauthorKarakaya, Hatice
dc.contributor.buuauthorÖzçetin, Hikmet
dc.contributor.buuauthorErtürk, Haluk
dc.contributor.buuauthorYücel, Ali
dc.contributor.buuauthorÖzmen, Ahmet
dc.contributor.buuauthorBaykara, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.tr_TR
dc.date.accessioned2021-07-05T08:02:13Z
dc.date.available2021-07-05T08:02:13Z
dc.date.issued2003-06
dc.descriptionConference: 13th Congress of the European-Society-of-Ophthalmology Location: Istanbul, Turkey Date: 3-7 Temmuz 2001.tr_TR
dc.description.abstractPurpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.en_US
dc.description.sponsorshipEuropean Soc Ophthalmolen_US
dc.identifier.citationTsubota, K. vd. (2003). “Tear function and ocular surface changes in keratoconus”. Ophthalmology, 110(6), 1110-1118.en_US
dc.identifier.endpage1118tr_TR
dc.identifier.issn0161-6420
dc.identifier.issue6tr_TR
dc.identifier.pubmed12799234tr_TR
dc.identifier.scopus2-s2.0-0038321499tr_TR
dc.identifier.startpage1110tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0161-6420(03)00261-6
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0161642003002616
dc.identifier.urihttp://hdl.handle.net/11452/21046
dc.identifier.volume110tr_TR
dc.identifier.wos000183614200017tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosCPCI-Sen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.collaborationYurt dışıen_US
dc.relation.journalOphthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGoblet cell-densityen_US
dc.subjectDry eye patientsen_US
dc.subjectBasement-membraneen_US
dc.subjectCorneasen_US
dc.subjectMucinen_US
dc.subjectExpressionen_US
dc.subjectFilmen_US
dc.subjectAbnormalitiesen_US
dc.subjectGlycoproteinen_US
dc.subjectInhibitorsen_US
dc.subjectOphthalmologyen_US
dc.subject.wosOphthalmologyen_US
dc.titleTear function and ocular surface changes in keratoconustr_TR
dc.typeArticle
dc.typeProceedings Paper
dc.wos.quartileQ1en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science