Oxidative stress and ferritin levels in haemodialysis patients

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dc.contributor.buuauthorŞenol, Emel
dc.contributor.buuauthorErsoy, Alpaslan
dc.contributor.buuauthorSarandol, Emre
dc.contributor.buuauthorYurtkuran, Mustafa
dc.contributor.buuauthorErdinç, Selda
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.scopusid24336329900tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.contributor.scopusid24334883200tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid7003389525tr_TR
dc.date.accessioned2021-12-14T07:49:55Z
dc.date.available2021-12-14T07:49:55Z
dc.date.issued2008-02
dc.description.abstractBackground. Increased oxidative stress (OS) and inflammation are associated with atherosclerotic coronary artery disease in haemodialysis (HD) patients. Ferritin may have other effects in addition to its role in storing intracellular iron. This study was performed to determine any relationships between markers of OS, nutrition and inflammation in HD patients with normal and high ferritin levels. Methods. Our cohort comprised 34 maintenance dialysis patients on erythropoietin therapy and 22 healthy controls. HD patients were divided into two groups: 17 with normal (<800 ng/ml) and 17 with high (>800 ng/ml) ferritin levels, and we measured lipid profile, albumin, highly sensitive C-reactive protein (hsCRP), anti-oxidant enzymes [whole blood glutathione peroxidase (Gpx), serum superoxide dismutase (SOD), paraoxonase, arylestherase (AE) and total anti-oxidant status (TAOC)], anti-oxidants (vitamin C) and lipid peroxidation products [red blood cell malondialdehyde (RBC MDA)]. Results. Compared with controls, the HD patients had higher serum urea, blood pressure, triglyceride, hsCRP, RBC MDA, SOD and TAOC values and lower albumin, low-density lipoprotein cholesterol, apolipoprotein AI, paraoxonase, AE and whole blood Gpx activities. Serum vitamin C, uric acid, apolipoprotein B, total- and high-density lipoprotein cholesterol, apolipoprotein B MDA, and lymphocyte levels in the HD patients with normal and high ferritin levels were similar. The OS markers of HD patients did not differ, whether or not they received intravenous iron supplementation or had transferrin saturations <50 or >= 50. Conclusion. HD patients are in a higher oxidative state, which results in the reduction of total anti-oxidant capacity and also have an increased inflammation status. We could not find a relationship between ferritin level and OS markers in HD patients receiving erythropoietin.en_US
dc.identifier.citationŞenol, E. vd. (2008). ''Oxidative stress and ferritin levels in haemodialysis patients''. Nephrology Dialysis Transplantation, 23(2), 665-672.en_US
dc.identifier.endpage672tr_TR
dc.identifier.issn0931-0509
dc.identifier.issue2tr_TR
dc.identifier.pubmed18039638tr_TR
dc.identifier.scopus2-s2.0-44449126216tr_TR
dc.identifier.startpage665tr_TR
dc.identifier.urihttps://doi.org/10.1093/ndt/gfm588
dc.identifier.urihttps://academic.oup.com/ndt/article/23/2/665/1851197
dc.identifier.urihttp://hdl.handle.net/11452/23234
dc.identifier.volume23tr_TR
dc.identifier.wos000253022300037tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.bapT-2006/14tr_TR
dc.relation.journalNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErythropoietinen_US
dc.subjectFerritinen_US
dc.subjectHaemodialysisen_US
dc.subjectInflammationen_US
dc.subjectNutritionen_US
dc.subjectOxidative stressen_US
dc.subjectChronic kidney-diseaseen_US
dc.subjectStage renal-diseaseen_US
dc.subjectSerum paraoxonaseen_US
dc.subjectOxidant stressen_US
dc.subjectLipid-peroxidationen_US
dc.subjectIron therapyen_US
dc.subjectProteinen_US
dc.subjectAtherosclerosisen_US
dc.subjectInflammationen_US
dc.subjectTransplantationen_US
dc.subjectUrology & nephrologyen_US
dc.subjectPlasmaen_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAngiotensin receptor antagonisten_US
dc.subject.emtreeApolipoprotein Ben_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeArylesteraseen_US
dc.subject.emtreeAscorbic aciden_US
dc.subject.emtreeBeta adrenergic receptor blocking agenten_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeCalcidiol 1 monooxygenaseen_US
dc.subject.emtreeCalcitriolen_US
dc.subject.emtreeCalcium channel blocking agenten_US
dc.subject.emtreeDipeptidyl carboxypeptidase inhibitoren_US
dc.subject.emtreeFerritinen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeHigh density lipoproteinen_US
dc.subject.emtreeIronen_US
dc.subject.emtreeLow density lipoproteinen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeRecombinant erythropoietinen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAtherosclerosisen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFerritin blood levelen_US
dc.subject.emtreeHemodialysisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHypertensionen_US
dc.subject.emtreeIron deficiencyen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeLymphocyte counten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNutritionen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeUremiaen_US
dc.subject.meshAdulten_US
dc.subject.meshErythropoietinen_US
dc.subject.meshFemaleen_US
dc.subject.meshFerritinsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshRenal dialysisen_US
dc.subject.scopusHemodialysis; Ascorbic Acid Deficiency; Chronic Kidney Failureen_US
dc.subject.wosTransplantationen_US
dc.subject.wosUrology & nephrologyen_US
dc.titleOxidative stress and ferritin levels in haemodialysis patientsen_US
dc.typeArticle
dc.wos.quartileQ1 (Urology & nephrology)en_US
dc.wos.quartileQ2 (Transplantation)en_US

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